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The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives.
J Psychopharmacol 2012; 26(1):150-63JP

Abstract

Alterations in emotion regulation processes may form the basis of psychopathologies. The endocannabinoid (eCB) system, composed of endogenous ligands, the enzymatic machinery in charge of their metabolism and the specific metabotropic receptors, has emerged as a major neuromodulatory system critically involved in the control of emotional homeostasis and stress responsiveness. Data from animal models indicate that the eCB system plays a key role in brain development, and is probably involved in the control of emotional states from early developmental stages. The present review summarizes the latest information on the role of the eCB system in emotionality and anxiety-related disorders throughout the lifespan. Putative therapeutic strategies based on the pharmacological modulation of this system will be discussed. Given the fact that the pharmacological modulation of the eCB system has recently arisen as a promising strategy in the management of anxiety and mood disorders, the potential efficacy of this pharmacological approach (i.e. blockers of the catabolic pathway) will be discussed, as well as pharmacological alternatives such as modulators of cannabinoid receptors other than the classical CB1 receptor, or administration of other plant-derived compounds (e.g. cannabidiol).

Authors+Show Affiliations

Department of Animal Physiology (Animal Physiology II), Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain. emmarco@bio.ucm.esNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21693551

Citation

Marco, Eva M., and Giovanni Laviola. "The Endocannabinoid System in the Regulation of Emotions Throughout Lifespan: a Discussion On Therapeutic Perspectives." Journal of Psychopharmacology (Oxford, England), vol. 26, no. 1, 2012, pp. 150-63.
Marco EM, Laviola G. The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives. J Psychopharmacol (Oxford). 2012;26(1):150-63.
Marco, E. M., & Laviola, G. (2012). The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives. Journal of Psychopharmacology (Oxford, England), 26(1), pp. 150-63. doi:10.1177/0269881111408459.
Marco EM, Laviola G. The Endocannabinoid System in the Regulation of Emotions Throughout Lifespan: a Discussion On Therapeutic Perspectives. J Psychopharmacol (Oxford). 2012;26(1):150-63. PubMed PMID: 21693551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives. AU - Marco,Eva M, AU - Laviola,Giovanni, Y1 - 2011/06/21/ PY - 2011/6/23/entrez PY - 2011/6/23/pubmed PY - 2012/8/22/medline SP - 150 EP - 63 JF - Journal of psychopharmacology (Oxford, England) JO - J. Psychopharmacol. (Oxford) VL - 26 IS - 1 N2 - Alterations in emotion regulation processes may form the basis of psychopathologies. The endocannabinoid (eCB) system, composed of endogenous ligands, the enzymatic machinery in charge of their metabolism and the specific metabotropic receptors, has emerged as a major neuromodulatory system critically involved in the control of emotional homeostasis and stress responsiveness. Data from animal models indicate that the eCB system plays a key role in brain development, and is probably involved in the control of emotional states from early developmental stages. The present review summarizes the latest information on the role of the eCB system in emotionality and anxiety-related disorders throughout the lifespan. Putative therapeutic strategies based on the pharmacological modulation of this system will be discussed. Given the fact that the pharmacological modulation of the eCB system has recently arisen as a promising strategy in the management of anxiety and mood disorders, the potential efficacy of this pharmacological approach (i.e. blockers of the catabolic pathway) will be discussed, as well as pharmacological alternatives such as modulators of cannabinoid receptors other than the classical CB1 receptor, or administration of other plant-derived compounds (e.g. cannabidiol). SN - 1461-7285 UR - https://www.unboundmedicine.com/medline/citation/21693551/abstract/The_endocannabinoid_system_in_the_regulation_of_emotions_throughout_lifespan:_a_discussion_on_therapeutic_perspectives_ L2 - http://journals.sagepub.com/doi/full/10.1177/0269881111408459?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -