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Vitamin D supplementation and status in infants: a prospective cohort observational study.
J Pediatr Gastroenterol Nutr 2011; 53(1):93-9JP

Abstract

OBJECTIVE

Vitamin D status in infants depends on supplementation. We examined the vitamin D status in relation to supplementation dose and scheme in infants.

PATIENTS AND METHODS

One hundred thirty-four infants age 6 months and 98 infants age 12 months (drop out 27%) were investigated. Vitamin D intake (diet, supplements), anthropometry, and 25-hydroxyvitamin D (25-OHD) serum concentration at the 6th and 12th months were assessed.

RESULTS

Vitamin D intake of 1062 ± 694 IU at the 6th month was not different from that at the 12th month (937 ± 618 IU). Vitamin D intake expressed in international units per kilogram of body weight decreased from 141 ± 80 IU/kg at the 6th month to 93 ± 62 IU/kg at the 12th month (P < 0.0001), which was associated with a reduction in 25-OHD from 43 ± 20 ng/mL to 29 ± 12 ng/mL, respectively (P < 0.0001). In the subgroup of everyday supplemented infants (n = 43), vitamin D intake decreased from 143 ± 88 IU/kg at the 6th month to 118 ± 60 IU/kg at the 12th month (P < 0.05), which coincided with a reduction of 25-OHD from 40 ± 19 ng/mL to 32 ± 13 ng/mL (P < 0.01). In the subgroup with variable supplementation habits (n = 32), vitamin D intake decreased from 146 ± 79 IU/kg to 77 ± 56 IU/kg (P < 0.001), which was associated with a reduction of 25-OHD from 42 ± 21 ng/mL to 25 ± 8 ng/mL (P < 0.0001). 25-OHD concentration change between the 6th and the 12th months negatively correlated with the 25-OHD level assessed at the 6th month (r = -0.82; P < 0.0001).

CONCLUSIONS

Vitamin D supplementation of infants should consider their rapid body weight increment. We postulate vitamin D daily dose close to 100 IU/kg body weight as favorable for infants up to age 12 months.

Authors+Show Affiliations

Department of Biochemistry and Experimental Medicine, Children's Memorial Health Institute, Aleja Dzieci Polskich, Warsaw, Poland. p.pludowski@czd.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21694542

Citation

Pludowski, Pawel, et al. "Vitamin D Supplementation and Status in Infants: a Prospective Cohort Observational Study." Journal of Pediatric Gastroenterology and Nutrition, vol. 53, no. 1, 2011, pp. 93-9.
Pludowski P, Socha P, Karczmarewicz E, et al. Vitamin D supplementation and status in infants: a prospective cohort observational study. J Pediatr Gastroenterol Nutr. 2011;53(1):93-9.
Pludowski, P., Socha, P., Karczmarewicz, E., Zagorecka, E., Lukaszkiewicz, J., Stolarczyk, A., ... Socha, J. (2011). Vitamin D supplementation and status in infants: a prospective cohort observational study. Journal of Pediatric Gastroenterology and Nutrition, 53(1), pp. 93-9. doi:10.1097/MPG.0b013e318216920f.
Pludowski P, et al. Vitamin D Supplementation and Status in Infants: a Prospective Cohort Observational Study. J Pediatr Gastroenterol Nutr. 2011;53(1):93-9. PubMed PMID: 21694542.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D supplementation and status in infants: a prospective cohort observational study. AU - Pludowski,Pawel, AU - Socha,Piotr, AU - Karczmarewicz,Elzbieta, AU - Zagorecka,Ewa, AU - Lukaszkiewicz,Jacek, AU - Stolarczyk,Anna, AU - Piotrowska-Jastrzebska,Janina, AU - Kryskiewicz,Edyta, AU - Lorenc,Roman S, AU - Socha,Jerzy, PY - 2011/6/23/entrez PY - 2011/6/23/pubmed PY - 2011/11/1/medline SP - 93 EP - 9 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 53 IS - 1 N2 - OBJECTIVE: Vitamin D status in infants depends on supplementation. We examined the vitamin D status in relation to supplementation dose and scheme in infants. PATIENTS AND METHODS: One hundred thirty-four infants age 6 months and 98 infants age 12 months (drop out 27%) were investigated. Vitamin D intake (diet, supplements), anthropometry, and 25-hydroxyvitamin D (25-OHD) serum concentration at the 6th and 12th months were assessed. RESULTS: Vitamin D intake of 1062 ± 694 IU at the 6th month was not different from that at the 12th month (937 ± 618 IU). Vitamin D intake expressed in international units per kilogram of body weight decreased from 141 ± 80 IU/kg at the 6th month to 93 ± 62 IU/kg at the 12th month (P < 0.0001), which was associated with a reduction in 25-OHD from 43 ± 20 ng/mL to 29 ± 12 ng/mL, respectively (P < 0.0001). In the subgroup of everyday supplemented infants (n = 43), vitamin D intake decreased from 143 ± 88 IU/kg at the 6th month to 118 ± 60 IU/kg at the 12th month (P < 0.05), which coincided with a reduction of 25-OHD from 40 ± 19 ng/mL to 32 ± 13 ng/mL (P < 0.01). In the subgroup with variable supplementation habits (n = 32), vitamin D intake decreased from 146 ± 79 IU/kg to 77 ± 56 IU/kg (P < 0.001), which was associated with a reduction of 25-OHD from 42 ± 21 ng/mL to 25 ± 8 ng/mL (P < 0.0001). 25-OHD concentration change between the 6th and the 12th months negatively correlated with the 25-OHD level assessed at the 6th month (r = -0.82; P < 0.0001). CONCLUSIONS: Vitamin D supplementation of infants should consider their rapid body weight increment. We postulate vitamin D daily dose close to 100 IU/kg body weight as favorable for infants up to age 12 months. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/21694542/Vitamin_D_supplementation_and_status_in_infants:_a_prospective_cohort_observational_study_ L2 - http://Insights.ovid.com/pubmed?pmid=21694542 DB - PRIME DP - Unbound Medicine ER -