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Letter: Necrobiotic xanthogranuloma of extremities in an elderly patient successfully treated with low-dose prednisolone.

Abstract

We describe a 93-year-old Japanese woman who developed a painful yellowish plaque with reddish border on her left lower leg. Histological evaluation demonstrated hyaline necrobiosis and granulomatous lesions composed of histiocytes (some with foamy cytoplasm), multinucleated giant cells, and numerous cholesterol crystals. Serum electrophoresis displayed the presence of an M-peak with IgG λ paraproteinemia. There was progressive ulcer formation in the location of the biopsy on the left leg. Multiple tender red dermal and subcutaneous skin nodules developed on her extremities. Oral administration of prednisolone 20 mg daily (0.5 mg/kg) was started. After 4 weeks, she obtained resolution of the skin lesions.

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    Source

    Dermatology online journal 17:6 2011 Jun 15 pg 13

    MeSH

    Aged, 80 and over
    Biopsy
    Female
    Glucocorticoids
    Humans
    Necrobiotic Xanthogranuloma
    Paraproteinemias
    Prednisolone

    Pub Type(s)

    Case Reports
    Letter

    Language

    eng

    PubMed ID

    21696693

    Citation

    Kawakami, Yoshio, and Toshiyuki Yamamoto. "Letter: Necrobiotic Xanthogranuloma of Extremities in an Elderly Patient Successfully Treated With Low-dose Prednisolone." Dermatology Online Journal, vol. 17, no. 6, 2011, p. 13.
    Kawakami Y, Yamamoto T. Letter: Necrobiotic xanthogranuloma of extremities in an elderly patient successfully treated with low-dose prednisolone. Dermatol Online J. 2011;17(6):13.
    Kawakami, Y., & Yamamoto, T. (2011). Letter: Necrobiotic xanthogranuloma of extremities in an elderly patient successfully treated with low-dose prednisolone. Dermatology Online Journal, 17(6), p. 13.
    Kawakami Y, Yamamoto T. Letter: Necrobiotic Xanthogranuloma of Extremities in an Elderly Patient Successfully Treated With Low-dose Prednisolone. Dermatol Online J. 2011 Jun 15;17(6):13. PubMed PMID: 21696693.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Letter: Necrobiotic xanthogranuloma of extremities in an elderly patient successfully treated with low-dose prednisolone. AU - Kawakami,Yoshio, AU - Yamamoto,Toshiyuki, Y1 - 2011/06/15/ PY - 2011/6/24/entrez PY - 2011/6/24/pubmed PY - 2011/10/28/medline SP - 13 EP - 13 JF - Dermatology online journal JO - Dermatol. Online J. VL - 17 IS - 6 N2 - We describe a 93-year-old Japanese woman who developed a painful yellowish plaque with reddish border on her left lower leg. Histological evaluation demonstrated hyaline necrobiosis and granulomatous lesions composed of histiocytes (some with foamy cytoplasm), multinucleated giant cells, and numerous cholesterol crystals. Serum electrophoresis displayed the presence of an M-peak with IgG λ paraproteinemia. There was progressive ulcer formation in the location of the biopsy on the left leg. Multiple tender red dermal and subcutaneous skin nodules developed on her extremities. Oral administration of prednisolone 20 mg daily (0.5 mg/kg) was started. After 4 weeks, she obtained resolution of the skin lesions. SN - 1087-2108 UR - https://www.unboundmedicine.com/medline/citation/21696693/Letter:_Necrobiotic_xanthogranuloma_of_extremities_in_an_elderly_patient_successfully_treated_with_low_dose_prednisolone_ L2 - http://dermatology.cdlib.org/1706/5_letters/13_11-00136/article.html DB - PRIME DP - Unbound Medicine ER -