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[Efficacy of alverina citrate and simethicone combination in abdominal pain and discomfort of irritable bowel syndrome].

Abstract

The alverina citrate and simethicone combination (ACS-Meteospazmil) is used for irritable bowel syndrome (IBS) for almost 20 years, but the supporting scientific evidence for efficacy is limited.

OBJECTIVE

to evaluate the effectiveness of ACS in patients with abdominal pain and discomfort at IBS.

METHODS

In a double-blind, randomized, placebo-controlled study enrolled 412 patients with IBS conform to Rome criteria III. Selection criterion in the study was to evaluate the intensity of abdominal pain or discomfort during the 2-week run-in period without medication, which according to analog scale (VAS) was to be 60-100 mm. With the help of an interactive voice communication system (IVCS), patients were randomized to treatment with either alverin citrate 60 mg with Simethicone 300 mg three times daily or corresponding placebo for 4 weeks.

RESULTS

For analyze of the results of the study were selected 409 patients. After 4 weeks, patients treated with ACS, was observed lower scores in the VAS assessment of abdominal pain or discomfort compared to placebo (mean--40 and 50 mm, p = 0.047) and a higher level of response to treatment (46.8% and 34.3%, respectively). Recorded side effects were similar in both groups.

CONCLUSION

The combination of ACS was significantly more effective in patients with IBS compared to placebo in reducing abdominal pain or discomfort.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

rus

PubMed ID

21698811

Citation

Wittmann, T, et al. "[Efficacy of Alverina Citrate and Simethicone Combination in Abdominal Pain and Discomfort of Irritable Bowel Syndrome]." Eksperimental'naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology, 2011, pp. 60-7.
Wittmann T, Paradovsky L, Ducrotte P, et al. [Efficacy of alverina citrate and simethicone combination in abdominal pain and discomfort of irritable bowel syndrome]. Eksp Klin Gastroenterol. 2011.
Wittmann, T., Paradovsky, L., Ducrotte, P., Bueno, L., & Andro-Delestrain, M. C. (2011). [Efficacy of alverina citrate and simethicone combination in abdominal pain and discomfort of irritable bowel syndrome]. Eksperimental'naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology, (3), 60-7.
Wittmann T, et al. [Efficacy of Alverina Citrate and Simethicone Combination in Abdominal Pain and Discomfort of Irritable Bowel Syndrome]. Eksp Klin Gastroenterol. 2011;(3)60-7. PubMed PMID: 21698811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Efficacy of alverina citrate and simethicone combination in abdominal pain and discomfort of irritable bowel syndrome]. AU - Wittmann,T, AU - Paradovsky,L, AU - Ducrotte,P, AU - Bueno,L, AU - Andro-Delestrain,M C T, PY - 2011/6/24/entrez PY - 2011/6/24/pubmed PY - 2011/7/13/medline SP - 60 EP - 7 JF - Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology JO - Eksp Klin Gastroenterol IS - 3 N2 - UNLABELLED: The alverina citrate and simethicone combination (ACS-Meteospazmil) is used for irritable bowel syndrome (IBS) for almost 20 years, but the supporting scientific evidence for efficacy is limited. OBJECTIVE: to evaluate the effectiveness of ACS in patients with abdominal pain and discomfort at IBS. METHODS: In a double-blind, randomized, placebo-controlled study enrolled 412 patients with IBS conform to Rome criteria III. Selection criterion in the study was to evaluate the intensity of abdominal pain or discomfort during the 2-week run-in period without medication, which according to analog scale (VAS) was to be 60-100 mm. With the help of an interactive voice communication system (IVCS), patients were randomized to treatment with either alverin citrate 60 mg with Simethicone 300 mg three times daily or corresponding placebo for 4 weeks. RESULTS: For analyze of the results of the study were selected 409 patients. After 4 weeks, patients treated with ACS, was observed lower scores in the VAS assessment of abdominal pain or discomfort compared to placebo (mean--40 and 50 mm, p = 0.047) and a higher level of response to treatment (46.8% and 34.3%, respectively). Recorded side effects were similar in both groups. CONCLUSION: The combination of ACS was significantly more effective in patients with IBS compared to placebo in reducing abdominal pain or discomfort. SN - 1682-8658 UR - https://www.unboundmedicine.com/medline/citation/21698811/[Efficacy_of_alverina_citrate_and_simethicone_combination_in_abdominal_pain_and_discomfort_of_irritable_bowel_syndrome]_ L2 - http://www.diseaseinfosearch.org/result/3876 DB - PRIME DP - Unbound Medicine ER -