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Preparation, characterization and dissolution enhancement of mefloquine hydrochloride-betaCD inclusion complex.
Pharmazie. 2011 Jun; 66(6):416-20.P

Abstract

The solid state properties and dissolution behaviour of binary systems of mefloquine hydrochloride (MH) with betaCD were investigated. MH-betaCD interaction in the solution state was studied by phase solubility analysis and demonstrates the ability of 3CD to complex with MH giving AL type profile with 120.34 M-1 stability constant. The kneading method was adopted to prepare binary sytems of MH with betaCD in 1:1 molar ratio. The solid inclusion was characterized by differential scanning calorimetry, fourier transformation infrared spectroscopy and X-ray powder diffractometry. Experimental results confirmed the existence of 1:1 inclusion complex of MH with ICD. Aqueous solubility of MH was found to be enhanced by 118% for inclusion complex. The dissolution properties of binary systems were studied in simulated gastric fluid without enzyme and compared with MH alone. The inclusion complex of MH prepared with 3CD showed a dissolution rate several times faster than that of physical mixture and pure drug.

Authors+Show Affiliations

Ashokrao Mane College of Pharmacy, Karad Maharashtra, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21699079

Citation

Patil, S S., and A L. Patil. "Preparation, Characterization and Dissolution Enhancement of Mefloquine hydrochloride-betaCD Inclusion Complex." Die Pharmazie, vol. 66, no. 6, 2011, pp. 416-20.
Patil SS, Patil AL. Preparation, characterization and dissolution enhancement of mefloquine hydrochloride-betaCD inclusion complex. Pharmazie. 2011;66(6):416-20.
Patil, S. S., & Patil, A. L. (2011). Preparation, characterization and dissolution enhancement of mefloquine hydrochloride-betaCD inclusion complex. Die Pharmazie, 66(6), 416-20.
Patil SS, Patil AL. Preparation, Characterization and Dissolution Enhancement of Mefloquine hydrochloride-betaCD Inclusion Complex. Pharmazie. 2011;66(6):416-20. PubMed PMID: 21699079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation, characterization and dissolution enhancement of mefloquine hydrochloride-betaCD inclusion complex. AU - Patil,S S, AU - Patil,A L, PY - 2011/6/25/entrez PY - 2011/6/28/pubmed PY - 2011/7/19/medline SP - 416 EP - 20 JF - Die Pharmazie JO - Pharmazie VL - 66 IS - 6 N2 - The solid state properties and dissolution behaviour of binary systems of mefloquine hydrochloride (MH) with betaCD were investigated. MH-betaCD interaction in the solution state was studied by phase solubility analysis and demonstrates the ability of 3CD to complex with MH giving AL type profile with 120.34 M-1 stability constant. The kneading method was adopted to prepare binary sytems of MH with betaCD in 1:1 molar ratio. The solid inclusion was characterized by differential scanning calorimetry, fourier transformation infrared spectroscopy and X-ray powder diffractometry. Experimental results confirmed the existence of 1:1 inclusion complex of MH with ICD. Aqueous solubility of MH was found to be enhanced by 118% for inclusion complex. The dissolution properties of binary systems were studied in simulated gastric fluid without enzyme and compared with MH alone. The inclusion complex of MH prepared with 3CD showed a dissolution rate several times faster than that of physical mixture and pure drug. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/21699079/Preparation_characterization_and_dissolution_enhancement_of_mefloquine_hydrochloride_betaCD_inclusion_complex_ DB - PRIME DP - Unbound Medicine ER -