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Rita Levi-Montalcini and the discovery of NGF, the first nerve cell growth factor.
Arch Ital Biol. 2011 Jun; 149(2):175-81.AI

Abstract

The nerve growth factor (NGF) is a signaling protein, discovered by Rita Levi-Montalcini in the early 1950's for its effect on growth and differentiation of specific populations of neurons of the peripheral nervous system. Originally identified as neurite outgrowth-stimulating factor, later studies revealed that the purified molecule has a number of target cells in the central nervous system and on nonneuronal cells. Moreover, recent studies showed the potential therapeutic properties of NGF in neuropathies of the central and peripheral nervous system and diseases of the eye and skin. Here I briefly describe the discovery of NGF, the early studies of Rita LeviMontalcini, a pioneer in modern neuroscience, and my scientific and human experience working in her laboratory for over 40 years.

Authors+Show Affiliations

Institute of Neurobiology and Molecular Medicine, Consiglio Nazionale delle ricerche, Rome, Italy. aloe@inmm.cnr.it

Pub Type(s)

Biography
Historical Article
Journal Article
Portrait

Language

eng

PubMed ID

21701989

Citation

Aloe, Luigi. "Rita Levi-Montalcini and the Discovery of NGF, the First Nerve Cell Growth Factor." Archives Italiennes De Biologie, vol. 149, no. 2, 2011, pp. 175-81.
Aloe L. Rita Levi-Montalcini and the discovery of NGF, the first nerve cell growth factor. Arch Ital Biol. 2011;149(2):175-81.
Aloe, L. (2011). Rita Levi-Montalcini and the discovery of NGF, the first nerve cell growth factor. Archives Italiennes De Biologie, 149(2), 175-81. https://doi.org/10.4449/aib.v149i2.1377
Aloe L. Rita Levi-Montalcini and the Discovery of NGF, the First Nerve Cell Growth Factor. Arch Ital Biol. 2011;149(2):175-81. PubMed PMID: 21701989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rita Levi-Montalcini and the discovery of NGF, the first nerve cell growth factor. A1 - Aloe,Luigi, PY - 2011/6/25/entrez PY - 2011/6/28/pubmed PY - 2012/6/22/medline SP - 175 EP - 81 JF - Archives italiennes de biologie JO - Arch Ital Biol VL - 149 IS - 2 N2 - The nerve growth factor (NGF) is a signaling protein, discovered by Rita Levi-Montalcini in the early 1950's for its effect on growth and differentiation of specific populations of neurons of the peripheral nervous system. Originally identified as neurite outgrowth-stimulating factor, later studies revealed that the purified molecule has a number of target cells in the central nervous system and on nonneuronal cells. Moreover, recent studies showed the potential therapeutic properties of NGF in neuropathies of the central and peripheral nervous system and diseases of the eye and skin. Here I briefly describe the discovery of NGF, the early studies of Rita LeviMontalcini, a pioneer in modern neuroscience, and my scientific and human experience working in her laboratory for over 40 years. SN - 0003-9829 UR - https://www.unboundmedicine.com/medline/citation/21701989/Rita_Levi_Montalcini_and_the_discovery_of_NGF_the_first_nerve_cell_growth_factor_ L2 - http://www.architalbiol.org/index.php/aib/article/view/149175/ DB - PRIME DP - Unbound Medicine ER -