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Preparation of silica-encapsulated hollow gold nanosphere tags using layer-by-layer method for multiplex surface-enhanced raman scattering detection.
Langmuir. 2011 Aug 16; 27(16):10228-33.L

Abstract

The use of silica shells offers many advantages in surface-enhanced Raman scattering (SERS)-based biological sensing applications due to their optical transparency, remarkable stability in environmental media, and improved biocompatibility. Here, we report a novel layer-by-layer method for the preparation of silica-hollow gold nanosphere (HGN) SERS tags. Poly(acrylic acid) was used to stabilize Raman reporter-tagged HGNs prior to the adsorption of a coupling agent, after which a silica shell was deposited onto the particle surface using Stöber's method. Importantly, competitive adsorption of the Raman reporter molecules and coupling agents, which results in unbalanced loading of reporter molecules on individual nanoparticles, was avoided using this method. As a result, the loading density of reporter molecules could be maximized. In addition, HGNs exhibited strong enhancement effects from the individual particles because of their ability to localize the surface electromagnetic fields through pinholes in the hollow particle structures. The proposed layer-by-layer silica-encapsulated HGN tags showed strong SERS signals as well as excellent multiplexing capabilities.

Authors+Show Affiliations

Department of Bionano Engineering, Hanyang University, Ansan 426-791, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21702512

Citation

Huang, Jianshe, et al. "Preparation of Silica-encapsulated Hollow Gold Nanosphere Tags Using Layer-by-layer Method for Multiplex Surface-enhanced Raman Scattering Detection." Langmuir : the ACS Journal of Surfaces and Colloids, vol. 27, no. 16, 2011, pp. 10228-33.
Huang J, Kim KH, Choi N, et al. Preparation of silica-encapsulated hollow gold nanosphere tags using layer-by-layer method for multiplex surface-enhanced raman scattering detection. Langmuir. 2011;27(16):10228-33.
Huang, J., Kim, K. H., Choi, N., Chon, H., Lee, S., & Choo, J. (2011). Preparation of silica-encapsulated hollow gold nanosphere tags using layer-by-layer method for multiplex surface-enhanced raman scattering detection. Langmuir : the ACS Journal of Surfaces and Colloids, 27(16), 10228-33. https://doi.org/10.1021/la201739n
Huang J, et al. Preparation of Silica-encapsulated Hollow Gold Nanosphere Tags Using Layer-by-layer Method for Multiplex Surface-enhanced Raman Scattering Detection. Langmuir. 2011 Aug 16;27(16):10228-33. PubMed PMID: 21702512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation of silica-encapsulated hollow gold nanosphere tags using layer-by-layer method for multiplex surface-enhanced raman scattering detection. AU - Huang,Jianshe, AU - Kim,Ki Hyung, AU - Choi,Namhyun, AU - Chon,Hyangah, AU - Lee,Sangyeop, AU - Choo,Jaebum, Y1 - 2011/07/12/ PY - 2011/6/28/entrez PY - 2011/6/28/pubmed PY - 2012/1/10/medline SP - 10228 EP - 33 JF - Langmuir : the ACS journal of surfaces and colloids JO - Langmuir VL - 27 IS - 16 N2 - The use of silica shells offers many advantages in surface-enhanced Raman scattering (SERS)-based biological sensing applications due to their optical transparency, remarkable stability in environmental media, and improved biocompatibility. Here, we report a novel layer-by-layer method for the preparation of silica-hollow gold nanosphere (HGN) SERS tags. Poly(acrylic acid) was used to stabilize Raman reporter-tagged HGNs prior to the adsorption of a coupling agent, after which a silica shell was deposited onto the particle surface using Stöber's method. Importantly, competitive adsorption of the Raman reporter molecules and coupling agents, which results in unbalanced loading of reporter molecules on individual nanoparticles, was avoided using this method. As a result, the loading density of reporter molecules could be maximized. In addition, HGNs exhibited strong enhancement effects from the individual particles because of their ability to localize the surface electromagnetic fields through pinholes in the hollow particle structures. The proposed layer-by-layer silica-encapsulated HGN tags showed strong SERS signals as well as excellent multiplexing capabilities. SN - 1520-5827 UR - https://www.unboundmedicine.com/medline/citation/21702512/Preparation_of_silica_encapsulated_hollow_gold_nanosphere_tags_using_layer_by_layer_method_for_multiplex_surface_enhanced_raman_scattering_detection_ L2 - https://doi.org/10.1021/la201739n DB - PRIME DP - Unbound Medicine ER -