Tags

Type your tag names separated by a space and hit enter

Investigation of compressibility and compactibility parameters of roller compacted Theophylline and its binary mixtures.
Int J Pharm. 2011 Sep 15; 416(1):97-103.IJ

Abstract

Roller compaction is a dry granulation method which results in tablets with inferior tensile strength comparing to direct compaction. The effect of roller compaction on compressibility and compactibility of tablets prepared from Theophylline anhydrate powder, Theophylline anhydrate fine powder and Theophylline monohydrate was investigated by measuring tensile strength of tablets as well as calculating compressibility and compactibility parameters by Leuenberger equation. The tablets under the same conditions were prepared by direct compaction and roller compaction. The binary mixtures of Theophylline anhydrate powder, Theophylline anhydrate fine powder, Theophylline monohydrate and microcrystalline cellulose were prepared in order to determine the optimal ratio of active material and excipients which delivers a sufficient mechanical strength of tablets. Tensile strength of MCC tablets and compactibility parameters calculated by Leuenberger equation after roller compaction was significantly decreased, while THAP, THAFP and THMO tablets showed only a minor reduction in compactibility and compressibility. Adding MCC to a mixture with Theophylline showed that the right choice and ratio of excipients can enable a sufficient mechanical strength of the tablets after roller compaction.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21704142

Citation

Hadžović, Ervina, et al. "Investigation of Compressibility and Compactibility Parameters of Roller Compacted Theophylline and Its Binary Mixtures." International Journal of Pharmaceutics, vol. 416, no. 1, 2011, pp. 97-103.
Hadžović E, Betz G, Hadžidedić S, et al. Investigation of compressibility and compactibility parameters of roller compacted Theophylline and its binary mixtures. Int J Pharm. 2011;416(1):97-103.
Hadžović, E., Betz, G., Hadžidedić, S., El-Arini, S. K., & Leuenberger, H. (2011). Investigation of compressibility and compactibility parameters of roller compacted Theophylline and its binary mixtures. International Journal of Pharmaceutics, 416(1), 97-103. https://doi.org/10.1016/j.ijpharm.2011.06.012
Hadžović E, et al. Investigation of Compressibility and Compactibility Parameters of Roller Compacted Theophylline and Its Binary Mixtures. Int J Pharm. 2011 Sep 15;416(1):97-103. PubMed PMID: 21704142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of compressibility and compactibility parameters of roller compacted Theophylline and its binary mixtures. AU - Hadžović,Ervina, AU - Betz,Gabriele, AU - Hadžidedić,Seherzada, AU - El-Arini,Silvia Kocova, AU - Leuenberger,Hans, Y1 - 2011/06/15/ PY - 2011/03/24/received PY - 2011/06/07/revised PY - 2011/06/09/accepted PY - 2011/6/28/entrez PY - 2011/6/28/pubmed PY - 2011/12/28/medline SP - 97 EP - 103 JF - International journal of pharmaceutics JO - Int J Pharm VL - 416 IS - 1 N2 - Roller compaction is a dry granulation method which results in tablets with inferior tensile strength comparing to direct compaction. The effect of roller compaction on compressibility and compactibility of tablets prepared from Theophylline anhydrate powder, Theophylline anhydrate fine powder and Theophylline monohydrate was investigated by measuring tensile strength of tablets as well as calculating compressibility and compactibility parameters by Leuenberger equation. The tablets under the same conditions were prepared by direct compaction and roller compaction. The binary mixtures of Theophylline anhydrate powder, Theophylline anhydrate fine powder, Theophylline monohydrate and microcrystalline cellulose were prepared in order to determine the optimal ratio of active material and excipients which delivers a sufficient mechanical strength of tablets. Tensile strength of MCC tablets and compactibility parameters calculated by Leuenberger equation after roller compaction was significantly decreased, while THAP, THAFP and THMO tablets showed only a minor reduction in compactibility and compressibility. Adding MCC to a mixture with Theophylline showed that the right choice and ratio of excipients can enable a sufficient mechanical strength of the tablets after roller compaction. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/21704142/Investigation_of_compressibility_and_compactibility_parameters_of_roller_compacted_Theophylline_and_its_binary_mixtures_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(11)00546-1 DB - PRIME DP - Unbound Medicine ER -