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Manganese in plasma: a promising biomarker of exposure to Mn in welders. A pilot study.
Toxicol Lett. 2012 Aug 13; 213(1):69-74.TL

Abstract

BACKGROUND

There is raising concern about the potential neurotoxic effects of manganese (Mn) inhalation exposure in welders. Because most of the airborne particles in welding fume are in the respirable fraction, their bioavailability is likely to be higher than for coarser dust exposure. No well-validated biomarker for Mn exposure is available.

OBJECTIVES

To investigate the interest of measuring Mn in plasma (Mn-P) and urine (Mn-U) as biomarkers of exposure in a group of 28 welders whose tasks were only welding-related.

METHODS

Ambient air exposure to Mn (Mn-air) was determined by personal full-shift measurements on Monday and Tuesday. On the same days, blood and urine samples were collected before and after the shift.

RESULTS

Mn-air varied from 1.3 to 729 μg/m(3) (GM 27.7). For Mn-U 65% of the values in welders were below the LOQ (0.20 μg/L). Compared to controls, the welders' Mn-P averaged 33% higher (1.5 vs 2.0 μg/L). In welders, the after-shift Mn-P values correlated well with Mn-air above 10 μg/m(3). In spite of similar Mn-air exposure on Monday and Tuesday, the relationships between Mn-air and after-shift Mn-P strikingly differed on Tuesday in that the inflection in the relationship was less obvious and the slope of the regression line (Mn-P after-shift/logMn-air) for a doubling of logMn-air was 2.3 times lower than on Monday. On Monday (the first day of the workweek), a Mn-P value of 2 μg/L could distinguish Mn-air exposure above or below 20 μg/m(3) with a sensitivity of 69% and a specificity of 82%.

CONCLUSIONS

This preliminary study indicates that Mn-P is a promising biomarker of current exposure to Mn in welders and lends biological plausibility to the intended change for the Mn TLV-TWA of 20 μg/m(3) proposed by ACGIH for respirable Mn particulate.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Hoet P
Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Université catholique de Louvain, Brussels, Belgium. perrine.hoet@uclouvain.be
Vanmarcke E
No affiliation info available
Geens T
No affiliation info available
Deumer G
No affiliation info available
Haufroid V
No affiliation info available
Roels HA
No affiliation info available

MeSH

AdultAirBiomarkersCase-Control StudiesHumansInhalation ExposureManganeseMiddle AgedOccupational ExposurePilot ProjectsWeldingYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21704687

Citation

Hoet, Perrine, et al. "Manganese in Plasma: a Promising Biomarker of Exposure to Mn in Welders. a Pilot Study." Toxicology Letters, vol. 213, no. 1, 2012, pp. 69-74.
Hoet P, Vanmarcke E, Geens T, et al. Manganese in plasma: a promising biomarker of exposure to Mn in welders. A pilot study. Toxicol Lett. 2012;213(1):69-74.
Hoet, P., Vanmarcke, E., Geens, T., Deumer, G., Haufroid, V., & Roels, H. A. (2012). Manganese in plasma: a promising biomarker of exposure to Mn in welders. A pilot study. Toxicology Letters, 213(1), 69-74. https://doi.org/10.1016/j.toxlet.2011.06.013
Hoet P, et al. Manganese in Plasma: a Promising Biomarker of Exposure to Mn in Welders. a Pilot Study. Toxicol Lett. 2012 Aug 13;213(1):69-74. PubMed PMID: 21704687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Manganese in plasma: a promising biomarker of exposure to Mn in welders. A pilot study. AU - Hoet,Perrine, AU - Vanmarcke,Els, AU - Geens,Tom, AU - Deumer,Gladys, AU - Haufroid,Vincent, AU - Roels,Harry A, Y1 - 2011/06/17/ PY - 2011/03/01/received PY - 2011/06/09/revised PY - 2011/06/10/accepted PY - 2011/6/28/entrez PY - 2011/6/28/pubmed PY - 2012/10/12/medline SP - 69 EP - 74 JF - Toxicology letters JO - Toxicol Lett VL - 213 IS - 1 N2 - BACKGROUND: There is raising concern about the potential neurotoxic effects of manganese (Mn) inhalation exposure in welders. Because most of the airborne particles in welding fume are in the respirable fraction, their bioavailability is likely to be higher than for coarser dust exposure. No well-validated biomarker for Mn exposure is available. OBJECTIVES: To investigate the interest of measuring Mn in plasma (Mn-P) and urine (Mn-U) as biomarkers of exposure in a group of 28 welders whose tasks were only welding-related. METHODS: Ambient air exposure to Mn (Mn-air) was determined by personal full-shift measurements on Monday and Tuesday. On the same days, blood and urine samples were collected before and after the shift. RESULTS: Mn-air varied from 1.3 to 729 μg/m(3) (GM 27.7). For Mn-U 65% of the values in welders were below the LOQ (0.20 μg/L). Compared to controls, the welders' Mn-P averaged 33% higher (1.5 vs 2.0 μg/L). In welders, the after-shift Mn-P values correlated well with Mn-air above 10 μg/m(3). In spite of similar Mn-air exposure on Monday and Tuesday, the relationships between Mn-air and after-shift Mn-P strikingly differed on Tuesday in that the inflection in the relationship was less obvious and the slope of the regression line (Mn-P after-shift/logMn-air) for a doubling of logMn-air was 2.3 times lower than on Monday. On Monday (the first day of the workweek), a Mn-P value of 2 μg/L could distinguish Mn-air exposure above or below 20 μg/m(3) with a sensitivity of 69% and a specificity of 82%. CONCLUSIONS: This preliminary study indicates that Mn-P is a promising biomarker of current exposure to Mn in welders and lends biological plausibility to the intended change for the Mn TLV-TWA of 20 μg/m(3) proposed by ACGIH for respirable Mn particulate. SN - 1879-3169 UR - https://www.unboundmedicine.com/medline/citation/21704687/Manganese_in_plasma:_a_promising_biomarker_of_exposure_to_Mn_in_welders__A_pilot_study_ DB - PRIME DP - Unbound Medicine ER -