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The association between the PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis update.
Mol Biol Rep. 2012 Apr; 39(4):3453-60.MB

Abstract

The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism confers susceptibility to rheumatoid arthritis (RA) in populations with different ethnicities. A meta-analysis was conducted on the PTPN22 C1858T polymorphism involving eighteen studies, which in total contained 20344 RA patients and 21828 controls. Meta-analysis revealed an association between the PTPN22 C1858T polymorphism T allele and RA in all subjects (odds ratio [OR] = 1.637, 95% confidence interval [CI] = 1.514-1.770, P < 0.001). After stratification by ethnicity, analysis indicated that the PTPN22 C1858T polymorphism T allele was significantly associated with RA in Europeans and Non-Europeans (OR = 1.587, 95% CI = 1.486-1.696, P < 0.001; OR = 1.748, 95% CI = 1.274-2.398, P < 0.001). Meta-analysis of the CT + TT genotype showed the same result patterns as that shown by the PTPN22 C1858T polymorphism T allele. Furthermore, a direct comparison between rheumatoid factor (RF)-positive and -negative subjects revealed a significant association with the T allele in RA patients with RF, but not in subjects without RF. In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with RA susceptibility in different ethnic groups, especially in Europeans, and the PTPN22 C1858T polymorphism T allele is significantly more prevalent in RF-positive patents than in RF-negative patients.

Authors+Show Affiliations

Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea. lyhcgh@korea.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21706348

Citation

Lee, Young Ho, et al. "The Association Between the PTPN22 C1858T Polymorphism and Rheumatoid Arthritis: a Meta-analysis Update." Molecular Biology Reports, vol. 39, no. 4, 2012, pp. 3453-60.
Lee YH, Bae SC, Choi SJ, et al. The association between the PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis update. Mol Biol Rep. 2012;39(4):3453-60.
Lee, Y. H., Bae, S. C., Choi, S. J., Ji, J. D., & Song, G. G. (2012). The association between the PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis update. Molecular Biology Reports, 39(4), 3453-60. https://doi.org/10.1007/s11033-011-1117-3
Lee YH, et al. The Association Between the PTPN22 C1858T Polymorphism and Rheumatoid Arthritis: a Meta-analysis Update. Mol Biol Rep. 2012;39(4):3453-60. PubMed PMID: 21706348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between the PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis update. AU - Lee,Young Ho, AU - Bae,Sang-Cheol, AU - Choi,Sung Jae, AU - Ji,Jong Dae, AU - Song,Gwan Gyu, Y1 - 2011/06/26/ PY - 2011/05/13/received PY - 2011/06/20/accepted PY - 2011/6/28/entrez PY - 2011/6/28/pubmed PY - 2012/6/29/medline SP - 3453 EP - 60 JF - Molecular biology reports JO - Mol. Biol. Rep. VL - 39 IS - 4 N2 - The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism confers susceptibility to rheumatoid arthritis (RA) in populations with different ethnicities. A meta-analysis was conducted on the PTPN22 C1858T polymorphism involving eighteen studies, which in total contained 20344 RA patients and 21828 controls. Meta-analysis revealed an association between the PTPN22 C1858T polymorphism T allele and RA in all subjects (odds ratio [OR] = 1.637, 95% confidence interval [CI] = 1.514-1.770, P < 0.001). After stratification by ethnicity, analysis indicated that the PTPN22 C1858T polymorphism T allele was significantly associated with RA in Europeans and Non-Europeans (OR = 1.587, 95% CI = 1.486-1.696, P < 0.001; OR = 1.748, 95% CI = 1.274-2.398, P < 0.001). Meta-analysis of the CT + TT genotype showed the same result patterns as that shown by the PTPN22 C1858T polymorphism T allele. Furthermore, a direct comparison between rheumatoid factor (RF)-positive and -negative subjects revealed a significant association with the T allele in RA patients with RF, but not in subjects without RF. In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with RA susceptibility in different ethnic groups, especially in Europeans, and the PTPN22 C1858T polymorphism T allele is significantly more prevalent in RF-positive patents than in RF-negative patients. SN - 1573-4978 UR - https://www.unboundmedicine.com/medline/citation/21706348/The_association_between_the_PTPN22_C1858T_polymorphism_and_rheumatoid_arthritis:_a_meta_analysis_update_ L2 - https://doi.org/10.1007/s11033-011-1117-3 DB - PRIME DP - Unbound Medicine ER -