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Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts.
Nat Prod Res. 2012; 26(5):479-83.NP

Abstract

In this study, the composition of fatty oil from Semen Ziziphi Spinosae and its cardiotonic activity on the heart isolated from a toad were studied. Oil-in-water (O/W) emulsions of fatty oil were prepared by the perfusion method. The fatty oil had a positive inotropic effect on isolated rat hearts at a concentration between 5 × 10(-3) and 2 × 10(-2) mL/10 mL, and the effect was in positive correlation with the concentration of calcium ions. In addition, this effect was inhibited by 2 mg/mL nifedipine, suggesting that the cardiotonic mechanism could be responsible for accelerating the inflow of calcium ions. Gas chromatography-mass spectrometry analysis showed that the main constituents of the fatty oil were 9-octadecenoic acid (43.32%), 9,12-octadecadienoic acid (42.57%), hexadecanoic acid (4.76%), 9-eicosenoic acid (2.95%), stearic acid (2.41%) and arachidic acid (0.81%). This preliminary study revealed that the fatty oil of Semen Ziziphi Spinosae exhibited remarkable cardiotonic activity in the tested models, and it is necessary to further reveal the effective substances of the fatty oil.

Authors+Show Affiliations

Department of Pharmaceutical Engineering, Tianjin University of Commerce, Tianjin, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21707231

Citation

Xie, Junbo, et al. "Composition of Fatty Oils From Semen Ziziphi Spinosae and Its Cardiotonic Effect On Isolated Toad Hearts." Natural Product Research, vol. 26, no. 5, 2012, pp. 479-83.
Xie J, Zhang Y, Wang L, et al. Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. Nat Prod Res. 2012;26(5):479-83.
Xie, J., Zhang, Y., Wang, L., Qi, W., & Zhang, M. (2012). Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. Natural Product Research, 26(5), 479-83. https://doi.org/10.1080/14786419.2010.516433
Xie J, et al. Composition of Fatty Oils From Semen Ziziphi Spinosae and Its Cardiotonic Effect On Isolated Toad Hearts. Nat Prod Res. 2012;26(5):479-83. PubMed PMID: 21707231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. AU - Xie,Junbo, AU - Zhang,Yanqing, AU - Wang,Lijuan, AU - Qi,Wuqin, AU - Zhang,Mingchun, Y1 - 2011/06/27/ PY - 2011/6/29/entrez PY - 2011/6/29/pubmed PY - 2012/6/2/medline SP - 479 EP - 83 JF - Natural product research JO - Nat Prod Res VL - 26 IS - 5 N2 - In this study, the composition of fatty oil from Semen Ziziphi Spinosae and its cardiotonic activity on the heart isolated from a toad were studied. Oil-in-water (O/W) emulsions of fatty oil were prepared by the perfusion method. The fatty oil had a positive inotropic effect on isolated rat hearts at a concentration between 5 × 10(-3) and 2 × 10(-2) mL/10 mL, and the effect was in positive correlation with the concentration of calcium ions. In addition, this effect was inhibited by 2 mg/mL nifedipine, suggesting that the cardiotonic mechanism could be responsible for accelerating the inflow of calcium ions. Gas chromatography-mass spectrometry analysis showed that the main constituents of the fatty oil were 9-octadecenoic acid (43.32%), 9,12-octadecadienoic acid (42.57%), hexadecanoic acid (4.76%), 9-eicosenoic acid (2.95%), stearic acid (2.41%) and arachidic acid (0.81%). This preliminary study revealed that the fatty oil of Semen Ziziphi Spinosae exhibited remarkable cardiotonic activity in the tested models, and it is necessary to further reveal the effective substances of the fatty oil. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/21707231/Composition_of_fatty_oils_from_semen_ziziphi_spinosae_and_its_cardiotonic_effect_on_isolated_toad_hearts_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2010.516433 DB - PRIME DP - Unbound Medicine ER -