Tags

Type your tag names separated by a space and hit enter

Daily urine iodine excretion while consuming a low-iodine diet in preparation for radioactive iodine therapy in a high iodine intake area.
Clin Endocrinol (Oxf) 2011; 75(6):851-6CE

Abstract

OBJECTIVE

Recommended durations of low-iodine diet (LID) in preparation for radioactive iodine therapy (RAIT) vary among major guidelines and are important for patients in areas where iodine intake is high. The aim of this study was to investigate daily changes in urine iodine excretion after starting a LID.

DESIGN

The daily iodine/creatinine (I/Cr) ratios and simple iodine concentration (simple I) of morning spot urine from 19 patients with differentiated thyroid carcinoma were measured for 2 weeks from the start of LID for RAIT preparation. We set the cut-off of I/Cr and simple I for poor LID preparation at >66·2 μg/gCr and >150 μg/l, respectively. The day when daily I/Cr or simple I became equal to or below the cut-off both by 95% CI and 90th percentile was defined as the end-point for the appropriate duration of LID for RAIT.

RESULTS

On day 6 of LID, the I/Cr ratio decreased below the cut-off (≤66·2 μg/gCr) both by 95% CI (0-60·8) and by 90th percentile (51·9). Simple I reached the cut-off (≤150 μg/l) on day 3 by both parameters (95%CI: 2·3-90·5; 90th percentile: 126·5). The morning spot-urine I/Cr and simple I on day 7 and day 14 were significantly lower than on day 0 (P < 0·05).

CONCLUSIONS

One week of a strict LID is enough to decrease the level of urine iodine excretion in preparation for RAIT even in high iodine intake areas. These results provide essential data for future outcome studies regarding LID preparation for RAIT.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

21707689

Citation

Kim, Hee Kyung, et al. "Daily Urine Iodine Excretion While Consuming a Low-iodine Diet in Preparation for Radioactive Iodine Therapy in a High Iodine Intake Area." Clinical Endocrinology, vol. 75, no. 6, 2011, pp. 851-6.
Kim HK, Lee SY, Lee JI, et al. Daily urine iodine excretion while consuming a low-iodine diet in preparation for radioactive iodine therapy in a high iodine intake area. Clin Endocrinol (Oxf). 2011;75(6):851-6.
Kim, H. K., Lee, S. Y., Lee, J. I., Jang, H. W., Kim, S. K., Chung, H. S., ... Kim, S. W. (2011). Daily urine iodine excretion while consuming a low-iodine diet in preparation for radioactive iodine therapy in a high iodine intake area. Clinical Endocrinology, 75(6), pp. 851-6. doi:10.1111/j.1365-2265.2011.04157.x.
Kim HK, et al. Daily Urine Iodine Excretion While Consuming a Low-iodine Diet in Preparation for Radioactive Iodine Therapy in a High Iodine Intake Area. Clin Endocrinol (Oxf). 2011;75(6):851-6. PubMed PMID: 21707689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Daily urine iodine excretion while consuming a low-iodine diet in preparation for radioactive iodine therapy in a high iodine intake area. AU - Kim,Hee Kyung, AU - Lee,Soo Youn, AU - Lee,Ji In, AU - Jang,Hye Won, AU - Kim,Soo Kyoung, AU - Chung,Hye Soo, AU - Tan,Alice Hyun Kyung, AU - Hur,Kyu Yeon, AU - Kim,Jae Hyeon, AU - Chung,Jae Hoon, AU - Kim,Sun Wook, PY - 2011/6/29/entrez PY - 2011/6/29/pubmed PY - 2012/3/6/medline SP - 851 EP - 6 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 75 IS - 6 N2 - OBJECTIVE: Recommended durations of low-iodine diet (LID) in preparation for radioactive iodine therapy (RAIT) vary among major guidelines and are important for patients in areas where iodine intake is high. The aim of this study was to investigate daily changes in urine iodine excretion after starting a LID. DESIGN: The daily iodine/creatinine (I/Cr) ratios and simple iodine concentration (simple I) of morning spot urine from 19 patients with differentiated thyroid carcinoma were measured for 2 weeks from the start of LID for RAIT preparation. We set the cut-off of I/Cr and simple I for poor LID preparation at >66·2 μg/gCr and >150 μg/l, respectively. The day when daily I/Cr or simple I became equal to or below the cut-off both by 95% CI and 90th percentile was defined as the end-point for the appropriate duration of LID for RAIT. RESULTS: On day 6 of LID, the I/Cr ratio decreased below the cut-off (≤66·2 μg/gCr) both by 95% CI (0-60·8) and by 90th percentile (51·9). Simple I reached the cut-off (≤150 μg/l) on day 3 by both parameters (95%CI: 2·3-90·5; 90th percentile: 126·5). The morning spot-urine I/Cr and simple I on day 7 and day 14 were significantly lower than on day 0 (P < 0·05). CONCLUSIONS: One week of a strict LID is enough to decrease the level of urine iodine excretion in preparation for RAIT even in high iodine intake areas. These results provide essential data for future outcome studies regarding LID preparation for RAIT. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/21707689/Daily_urine_iodine_excretion_while_consuming_a_low_iodine_diet_in_preparation_for_radioactive_iodine_therapy_in_a_high_iodine_intake_area_ L2 - https://doi.org/10.1111/j.1365-2265.2011.04157.x DB - PRIME DP - Unbound Medicine ER -