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A prospective study of prepregnancy dietary iron intake and risk for gestational diabetes mellitus.
Diabetes Care. 2011 Jul; 34(7):1557-63.DC

Abstract

OBJECTIVE

It is important to identify modifiable factors that may lower gestational diabetes mellitus (GDM) risk. Dietary iron is of particular interest given that iron is a strong prooxidant, and high body iron levels can damage pancreatic β-cell function and impair glucose metabolism. The current study is to determine if prepregnancy dietary and supplemental iron intakes are associated with the risk of GDM.

RESEARCH DESIGN AND METHODS

A prospective study was conducted among 13,475 women who reported a singleton pregnancy between 1991 and 2001 in the Nurses' Health Study II. A total of 867 incident GDM cases were reported. Pooled logistic regression was used to estimate the relative risk (RR) of GDM by quintiles of iron intake controlling for dietary and nondietary risk factors.

RESULTS

Dietary heme iron intake was positively and significantly associated with GDM risk. After adjusting for age, BMI, and other risk factors, RRs (95% CIs) across increasing quintiles of heme iron were 1.0 (reference), 1.11 (0.87-1.43), 1.31 (1.03-1.68), 1.51 (1.17-1.93), and 1.58 (1.21-2.08), respectively (P for linear trend 0.0001). The multivariate adjusted RR for GDM associated with every 0.5-mg per day of increase in intake was 1.22 (1.10-1.36). No significant associations were observed between total dietary, nonheme, or supplemental iron intake and GDM risk.

CONCLUSIONS

These findings suggest that higher prepregnancy intake of dietary heme iron is associated with an increased GDM risk.

Authors+Show Affiliations

Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA. bowerska2@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

21709294

Citation

Bowers, Katherine, et al. "A Prospective Study of Prepregnancy Dietary Iron Intake and Risk for Gestational Diabetes Mellitus." Diabetes Care, vol. 34, no. 7, 2011, pp. 1557-63.
Bowers K, Yeung E, Williams MA, et al. A prospective study of prepregnancy dietary iron intake and risk for gestational diabetes mellitus. Diabetes Care. 2011;34(7):1557-63.
Bowers, K., Yeung, E., Williams, M. A., Qi, L., Tobias, D. K., Hu, F. B., & Zhang, C. (2011). A prospective study of prepregnancy dietary iron intake and risk for gestational diabetes mellitus. Diabetes Care, 34(7), 1557-63. https://doi.org/10.2337/dc11-0134
Bowers K, et al. A Prospective Study of Prepregnancy Dietary Iron Intake and Risk for Gestational Diabetes Mellitus. Diabetes Care. 2011;34(7):1557-63. PubMed PMID: 21709294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of prepregnancy dietary iron intake and risk for gestational diabetes mellitus. AU - Bowers,Katherine, AU - Yeung,Edwina, AU - Williams,Michelle A, AU - Qi,Lu, AU - Tobias,Deirdre K, AU - Hu,Frank B, AU - Zhang,Cuilin, PY - 2011/6/29/entrez PY - 2011/6/29/pubmed PY - 2011/10/20/medline SP - 1557 EP - 63 JF - Diabetes care JO - Diabetes Care VL - 34 IS - 7 N2 - OBJECTIVE: It is important to identify modifiable factors that may lower gestational diabetes mellitus (GDM) risk. Dietary iron is of particular interest given that iron is a strong prooxidant, and high body iron levels can damage pancreatic β-cell function and impair glucose metabolism. The current study is to determine if prepregnancy dietary and supplemental iron intakes are associated with the risk of GDM. RESEARCH DESIGN AND METHODS: A prospective study was conducted among 13,475 women who reported a singleton pregnancy between 1991 and 2001 in the Nurses' Health Study II. A total of 867 incident GDM cases were reported. Pooled logistic regression was used to estimate the relative risk (RR) of GDM by quintiles of iron intake controlling for dietary and nondietary risk factors. RESULTS: Dietary heme iron intake was positively and significantly associated with GDM risk. After adjusting for age, BMI, and other risk factors, RRs (95% CIs) across increasing quintiles of heme iron were 1.0 (reference), 1.11 (0.87-1.43), 1.31 (1.03-1.68), 1.51 (1.17-1.93), and 1.58 (1.21-2.08), respectively (P for linear trend 0.0001). The multivariate adjusted RR for GDM associated with every 0.5-mg per day of increase in intake was 1.22 (1.10-1.36). No significant associations were observed between total dietary, nonheme, or supplemental iron intake and GDM risk. CONCLUSIONS: These findings suggest that higher prepregnancy intake of dietary heme iron is associated with an increased GDM risk. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/21709294/A_prospective_study_of_prepregnancy_dietary_iron_intake_and_risk_for_gestational_diabetes_mellitus_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=21709294 DB - PRIME DP - Unbound Medicine ER -