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A randomized comparison of excimer laser versus narrow-band ultraviolet B phototherapy after punch grafting in stable vitiligo patients.
J Eur Acad Dermatol Venereol. 2012 Jun; 26(6):690-5.JE

Abstract

Background Ultraviolet radiation following punch grafting may stimulate the migration of melanocytes from the grafts into the vitiliginous skin, thereby increasing the rate of repigmentation. We compared the effects of the 308-nm xenon chloride excimer laser (EL) vs. narrow-band ultraviolet B (NB-UVB) after punch grafting in patients with vitiligo. Objectives The aims of this study were to evaluate (i) repigmentation (%); (ii) treatment satisfaction; and (iii) patient preferences for EL vs. NB-UVB therapy after punch grafting in vitiligo. Methods Fourteen patients were treated with the punch-grafting technique on two symmetrical vitiligo patches. Starting 1 week after the punch grafting, the vitiligo patches were treated twice a week during 3 months, with EL on one side and with NB-UVB on the other side. Repigmentation (%) was measured by a digital image analysis system. Patients' satisfaction and preference for treatment were also assessed. Results Whereas both treatment modalities induced repigmentation, no statistically significant difference was found in grade of repigmentation after 3 months. With EL, 71.4% lower cumulative dose was reached. Patients were significantly more satisfied with NB-UVB and preferred it over EL. Conclusions The choice between EL and NB-UVB cannot solely be based on repigmentation, but rather on other factors, such as patients' preferences. However, given the lower UV dose of EL, we recommend its use in vulnerable populations, such as in small children and patients with sun-damaged skin with a history of long-term UVB treatment.

Authors+Show Affiliations

Netherlands Institute for Pigment Disorders, Department of Dermatology, Academic Medical Centre, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21711467

Citation

Linthorst Homan, M W., et al. "A Randomized Comparison of Excimer Laser Versus Narrow-band Ultraviolet B Phototherapy After Punch Grafting in Stable Vitiligo Patients." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 26, no. 6, 2012, pp. 690-5.
Linthorst Homan MW, Spuls PI, Nieuweboer-Krobotova L, et al. A randomized comparison of excimer laser versus narrow-band ultraviolet B phototherapy after punch grafting in stable vitiligo patients. J Eur Acad Dermatol Venereol. 2012;26(6):690-5.
Linthorst Homan, M. W., Spuls, P. I., Nieuweboer-Krobotova, L., de Korte, J., Sprangers, M. A., Bos, J. D., Wolkerstorfer, A., & van der Veen, J. P. (2012). A randomized comparison of excimer laser versus narrow-band ultraviolet B phototherapy after punch grafting in stable vitiligo patients. Journal of the European Academy of Dermatology and Venereology : JEADV, 26(6), 690-5. https://doi.org/10.1111/j.1468-3083.2011.04147.x
Linthorst Homan MW, et al. A Randomized Comparison of Excimer Laser Versus Narrow-band Ultraviolet B Phototherapy After Punch Grafting in Stable Vitiligo Patients. J Eur Acad Dermatol Venereol. 2012;26(6):690-5. PubMed PMID: 21711467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized comparison of excimer laser versus narrow-band ultraviolet B phototherapy after punch grafting in stable vitiligo patients. AU - Linthorst Homan,M W, AU - Spuls,Ph I, AU - Nieuweboer-Krobotova,L, AU - de Korte,J, AU - Sprangers,M A G, AU - Bos,J D, AU - Wolkerstorfer,A, AU - van der Veen,J P W, Y1 - 2011/06/29/ PY - 2011/6/30/entrez PY - 2011/6/30/pubmed PY - 2012/9/19/medline SP - 690 EP - 5 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 26 IS - 6 N2 - Background Ultraviolet radiation following punch grafting may stimulate the migration of melanocytes from the grafts into the vitiliginous skin, thereby increasing the rate of repigmentation. We compared the effects of the 308-nm xenon chloride excimer laser (EL) vs. narrow-band ultraviolet B (NB-UVB) after punch grafting in patients with vitiligo. Objectives The aims of this study were to evaluate (i) repigmentation (%); (ii) treatment satisfaction; and (iii) patient preferences for EL vs. NB-UVB therapy after punch grafting in vitiligo. Methods Fourteen patients were treated with the punch-grafting technique on two symmetrical vitiligo patches. Starting 1 week after the punch grafting, the vitiligo patches were treated twice a week during 3 months, with EL on one side and with NB-UVB on the other side. Repigmentation (%) was measured by a digital image analysis system. Patients' satisfaction and preference for treatment were also assessed. Results Whereas both treatment modalities induced repigmentation, no statistically significant difference was found in grade of repigmentation after 3 months. With EL, 71.4% lower cumulative dose was reached. Patients were significantly more satisfied with NB-UVB and preferred it over EL. Conclusions The choice between EL and NB-UVB cannot solely be based on repigmentation, but rather on other factors, such as patients' preferences. However, given the lower UV dose of EL, we recommend its use in vulnerable populations, such as in small children and patients with sun-damaged skin with a history of long-term UVB treatment. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/21711467/A_randomized_comparison_of_excimer_laser_versus_narrow_band_ultraviolet_B_phototherapy_after_punch_grafting_in_stable_vitiligo_patients_ L2 - https://doi.org/10.1111/j.1468-3083.2011.04147.x DB - PRIME DP - Unbound Medicine ER -