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Lymph-node metastases in invasive lobular carcinoma are different from those in ductal carcinoma of the breast.
J Clin Pathol. 2011 Nov; 64(11):995-1000.JC

Abstract

AIM

Invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) of the breast are distinct morphological entities with different biological features and clinical behaviour. In the present study, the authors compare the axillary-lymph-node (ALN) status of patients with grade-matched ILC (no=426) and IDC (no=820). The pattern of nodal metastatic deposits (nodular, sinusoidal and diffuse) and the proportion of involved nodes were also analysed in a selected group of 246 tumours, which were associated with a single positive ALN.

RESULTS

Compared with grade-matched IDC, ILC was associated with a higher nodal stage (13.1% vs 4.5% of ILC and IDC were stage 3), higher absolute number of positive nodes and higher ratio of positive nodes (0.46±0.30 and 0.33±0.23 in ILC and IDC respectively). These differences were maintained in the different size subgroups. The most common metastatic morphological pattern was nodular in both types of carcinomas. A sinusoidal pattern was more frequent in IDC, and the diffuse pattern was more frequent in ILC. Despite these differences, ILC and grade-matched IDC exhibited similar rates of regional recurrences (RR) and breast-cancer survival.

CONCLUSION

This study provides clinical evidence which further demonstrates that ILC and IDC are biologically distinct entities with different lymph-node involvement patterns and ILC having a tendency to metastasise to more nodes than IDC. However, this difference was not associated with a significant impact on patient outcome.

Authors+Show Affiliations

Departments of Histopathology and Surgery, Nottingham University Hospitals NHS Trust, The University of Nottingham, Nottingham, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21712309

Citation

Fernández, Beatriz, et al. "Lymph-node Metastases in Invasive Lobular Carcinoma Are Different From Those in Ductal Carcinoma of the Breast." Journal of Clinical Pathology, vol. 64, no. 11, 2011, pp. 995-1000.
Fernández B, Paish EC, Green AR, et al. Lymph-node metastases in invasive lobular carcinoma are different from those in ductal carcinoma of the breast. J Clin Pathol. 2011;64(11):995-1000.
Fernández, B., Paish, E. C., Green, A. R., Lee, A. H., Macmillan, R. D., Ellis, I. O., & Rakha, E. A. (2011). Lymph-node metastases in invasive lobular carcinoma are different from those in ductal carcinoma of the breast. Journal of Clinical Pathology, 64(11), 995-1000. https://doi.org/10.1136/jclinpath-2011-200151
Fernández B, et al. Lymph-node Metastases in Invasive Lobular Carcinoma Are Different From Those in Ductal Carcinoma of the Breast. J Clin Pathol. 2011;64(11):995-1000. PubMed PMID: 21712309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lymph-node metastases in invasive lobular carcinoma are different from those in ductal carcinoma of the breast. AU - Fernández,Beatriz, AU - Paish,E Claire, AU - Green,Andrew R, AU - Lee,Andrew H S, AU - Macmillan,R Douglas, AU - Ellis,Ian O, AU - Rakha,Emad A, Y1 - 2011/06/28/ PY - 2011/6/30/entrez PY - 2011/6/30/pubmed PY - 2012/1/14/medline SP - 995 EP - 1000 JF - Journal of clinical pathology JO - J. Clin. Pathol. VL - 64 IS - 11 N2 - AIM: Invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) of the breast are distinct morphological entities with different biological features and clinical behaviour. In the present study, the authors compare the axillary-lymph-node (ALN) status of patients with grade-matched ILC (no=426) and IDC (no=820). The pattern of nodal metastatic deposits (nodular, sinusoidal and diffuse) and the proportion of involved nodes were also analysed in a selected group of 246 tumours, which were associated with a single positive ALN. RESULTS: Compared with grade-matched IDC, ILC was associated with a higher nodal stage (13.1% vs 4.5% of ILC and IDC were stage 3), higher absolute number of positive nodes and higher ratio of positive nodes (0.46±0.30 and 0.33±0.23 in ILC and IDC respectively). These differences were maintained in the different size subgroups. The most common metastatic morphological pattern was nodular in both types of carcinomas. A sinusoidal pattern was more frequent in IDC, and the diffuse pattern was more frequent in ILC. Despite these differences, ILC and grade-matched IDC exhibited similar rates of regional recurrences (RR) and breast-cancer survival. CONCLUSION: This study provides clinical evidence which further demonstrates that ILC and IDC are biologically distinct entities with different lymph-node involvement patterns and ILC having a tendency to metastasise to more nodes than IDC. However, this difference was not associated with a significant impact on patient outcome. SN - 1472-4146 UR - https://www.unboundmedicine.com/medline/citation/21712309/Lymph_node_metastases_in_invasive_lobular_carcinoma_are_different_from_those_in_ductal_carcinoma_of_the_breast_ L2 - http://jcp.bmj.com/cgi/pmidlookup?view=long&pmid=21712309 DB - PRIME DP - Unbound Medicine ER -