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Red blood cell distribution width is an independent predictor of mortality in acute kidney injury patients treated with continuous renal replacement therapy.
Nephrol Dial Transplant. 2012 Feb; 27(2):589-94.ND

Abstract

BACKGROUND

A potential independent association was recently demonstrated between high red blood cell distribution width (RDW) and the risk of all-cause mortality in patients with cardiovascular disease, although the mechanism remains unclear. However, there have been no reports on the relationship between RDW and mortality in acute kidney injury (AKI) patients treated with continuous renal replacement therapy (CRRT). In this study, we assessed whether RDW was associated with mortality in AKI patients on CRRT treatment in the intensive care unit (ICU).

METHODS

We enrolled 470 patients with AKI who were treated with CRRT at the Yonsei University Medical Center ICU from August 2007 to September 2009 in this study. We performed a retrospective analysis of demographic, biochemical parameters and patient outcomes. Following CRRT treatment, 28-day all-cause mortality was evaluated.

RESULTS

At the initiation of CRRT treatment, RDW level was significantly correlated with white blood cell count, hemoglobin (Hb) and total cholesterol. Patients with high RDW levels exhibited significantly higher 28-day mortality rates than patients with low RDW levels (P < 0.01). Baseline RDW level, Sequential Organ Failure Assessment (SOFA) score, low mean arterial pressure (MAP) and low cholesterol levels were independent risk factors for mortality. In multivariate Cox proportional hazard analyses, RDW at CRRT initiation was an independent predictor for 28-day all-cause mortality after adjusting for age, gender, MAP, Hb, albumin, total cholesterol, C-reactive protein and SOFA score.

CONCLUSION

Our study demonstrates that RDW could be an additive predictor for all-cause mortality in AKI patients on CRRT treatment in the ICU.

Authors+Show Affiliations

Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21712489

Citation

Oh, Hyung Jung, et al. "Red Blood Cell Distribution Width Is an Independent Predictor of Mortality in Acute Kidney Injury Patients Treated With Continuous Renal Replacement Therapy." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 27, no. 2, 2012, pp. 589-94.
Oh HJ, Park JT, Kim JK, et al. Red blood cell distribution width is an independent predictor of mortality in acute kidney injury patients treated with continuous renal replacement therapy. Nephrol Dial Transplant. 2012;27(2):589-94.
Oh, H. J., Park, J. T., Kim, J. K., Yoo, D. E., Kim, S. J., Han, S. H., Kang, S. W., Choi, K. H., & Yoo, T. H. (2012). Red blood cell distribution width is an independent predictor of mortality in acute kidney injury patients treated with continuous renal replacement therapy. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 27(2), 589-94. https://doi.org/10.1093/ndt/gfr307
Oh HJ, et al. Red Blood Cell Distribution Width Is an Independent Predictor of Mortality in Acute Kidney Injury Patients Treated With Continuous Renal Replacement Therapy. Nephrol Dial Transplant. 2012;27(2):589-94. PubMed PMID: 21712489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red blood cell distribution width is an independent predictor of mortality in acute kidney injury patients treated with continuous renal replacement therapy. AU - Oh,Hyung Jung, AU - Park,Jung Tak, AU - Kim,Jwa-Kyung, AU - Yoo,Dong Eun, AU - Kim,Seung Jun, AU - Han,Seung Hyeok, AU - Kang,Shin-Wook, AU - Choi,Kyu Hun, AU - Yoo,Tae-Hyun, Y1 - 2011/06/28/ PY - 2011/6/30/entrez PY - 2011/6/30/pubmed PY - 2012/9/14/medline SP - 589 EP - 94 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 27 IS - 2 N2 - BACKGROUND: A potential independent association was recently demonstrated between high red blood cell distribution width (RDW) and the risk of all-cause mortality in patients with cardiovascular disease, although the mechanism remains unclear. However, there have been no reports on the relationship between RDW and mortality in acute kidney injury (AKI) patients treated with continuous renal replacement therapy (CRRT). In this study, we assessed whether RDW was associated with mortality in AKI patients on CRRT treatment in the intensive care unit (ICU). METHODS: We enrolled 470 patients with AKI who were treated with CRRT at the Yonsei University Medical Center ICU from August 2007 to September 2009 in this study. We performed a retrospective analysis of demographic, biochemical parameters and patient outcomes. Following CRRT treatment, 28-day all-cause mortality was evaluated. RESULTS: At the initiation of CRRT treatment, RDW level was significantly correlated with white blood cell count, hemoglobin (Hb) and total cholesterol. Patients with high RDW levels exhibited significantly higher 28-day mortality rates than patients with low RDW levels (P < 0.01). Baseline RDW level, Sequential Organ Failure Assessment (SOFA) score, low mean arterial pressure (MAP) and low cholesterol levels were independent risk factors for mortality. In multivariate Cox proportional hazard analyses, RDW at CRRT initiation was an independent predictor for 28-day all-cause mortality after adjusting for age, gender, MAP, Hb, albumin, total cholesterol, C-reactive protein and SOFA score. CONCLUSION: Our study demonstrates that RDW could be an additive predictor for all-cause mortality in AKI patients on CRRT treatment in the ICU. SN - 1460-2385 UR - https://www.unboundmedicine.com/medline/citation/21712489/Red_blood_cell_distribution_width_is_an_independent_predictor_of_mortality_in_acute_kidney_injury_patients_treated_with_continuous_renal_replacement_therapy_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfr307 DB - PRIME DP - Unbound Medicine ER -