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Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: induced diabetic rat tissues.
Mol Cell Biochem. 2011 Dec; 358(1-2):121-9.MC

Abstract

Quercitrin, a bio flavonoid, was investigated for its antioxidant potential in streptozotocin (STZ)-induced diabetic rats. Rats were induced diabetic by a single intraperitoneal injection of streptozotocin (50 mg/kg). The levels of fasting plasma glucose and insulin were estimated. Lipid peroxidative products and antioxidants were estimated in pancreas, liver, and kidney. Histopathological studies were carried out in these tissues. A significant (P < 0.05) increase in the levels of fasting plasma glucose and lipid peroxidative products (thiobarbituric acid reactive substances and lipid hydroperoxides) and a significant (P < 0.05) decrease in plasma insulin, enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase), and nonenzymic antioxidants (reduced glutathione, vitamin C, and E) in diabetic pancreas, liver, and kidney were observed. Oral administration of quercitrin (30 mg/kg) for a period of 30 days significantly (P < 0.05) decreased fasting plasma glucose, increased insulin levels, and improved the antioxidant status of diabetic rats by decreasing lipid peroxidative products and increasing enzymic and nonenzymic antioxidants. Normal rats treated with quercitrin (30 mg/kg) showed no significant (P < 0.05) effect on any of the parameters studied. Histopathological studies of the pancreas, liver, and kidney showed the protective role of quercitrin. Thus, our study clearly shows that quercitrin has antioxidant effect in STZ-induced experimental diabetes.

Authors+Show Affiliations

Department of Biochemistry, KMG College of Arts and Science, Gudiyattam, Vellore District, Vellore 632 602, Tamil Nadu, India. kmrbabugym@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21713411

Citation

Babujanarthanam, Ranganathan, et al. "Quercitrin a Bioflavonoid Improves the Antioxidant Status in Streptozotocin: Induced Diabetic Rat Tissues." Molecular and Cellular Biochemistry, vol. 358, no. 1-2, 2011, pp. 121-9.
Babujanarthanam R, Kavitha P, Mahadeva Rao US, et al. Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: induced diabetic rat tissues. Mol Cell Biochem. 2011;358(1-2):121-9.
Babujanarthanam, R., Kavitha, P., Mahadeva Rao, U. S., & Pandian, M. R. (2011). Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: induced diabetic rat tissues. Molecular and Cellular Biochemistry, 358(1-2), 121-9. https://doi.org/10.1007/s11010-011-0927-x
Babujanarthanam R, et al. Quercitrin a Bioflavonoid Improves the Antioxidant Status in Streptozotocin: Induced Diabetic Rat Tissues. Mol Cell Biochem. 2011;358(1-2):121-9. PubMed PMID: 21713411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: induced diabetic rat tissues. AU - Babujanarthanam,Ranganathan, AU - Kavitha,Purushothaman, AU - Mahadeva Rao,U S, AU - Pandian,Moses Rajasekara, Y1 - 2011/06/29/ PY - 2010/12/15/received PY - 2011/06/21/accepted PY - 2011/6/30/entrez PY - 2011/6/30/pubmed PY - 2012/2/22/medline SP - 121 EP - 9 JF - Molecular and cellular biochemistry JO - Mol Cell Biochem VL - 358 IS - 1-2 N2 - Quercitrin, a bio flavonoid, was investigated for its antioxidant potential in streptozotocin (STZ)-induced diabetic rats. Rats were induced diabetic by a single intraperitoneal injection of streptozotocin (50 mg/kg). The levels of fasting plasma glucose and insulin were estimated. Lipid peroxidative products and antioxidants were estimated in pancreas, liver, and kidney. Histopathological studies were carried out in these tissues. A significant (P < 0.05) increase in the levels of fasting plasma glucose and lipid peroxidative products (thiobarbituric acid reactive substances and lipid hydroperoxides) and a significant (P < 0.05) decrease in plasma insulin, enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase), and nonenzymic antioxidants (reduced glutathione, vitamin C, and E) in diabetic pancreas, liver, and kidney were observed. Oral administration of quercitrin (30 mg/kg) for a period of 30 days significantly (P < 0.05) decreased fasting plasma glucose, increased insulin levels, and improved the antioxidant status of diabetic rats by decreasing lipid peroxidative products and increasing enzymic and nonenzymic antioxidants. Normal rats treated with quercitrin (30 mg/kg) showed no significant (P < 0.05) effect on any of the parameters studied. Histopathological studies of the pancreas, liver, and kidney showed the protective role of quercitrin. Thus, our study clearly shows that quercitrin has antioxidant effect in STZ-induced experimental diabetes. SN - 1573-4919 UR - https://www.unboundmedicine.com/medline/citation/21713411/Quercitrin_a_bioflavonoid_improves_the_antioxidant_status_in_streptozotocin:_induced_diabetic_rat_tissues_ L2 - https://doi.org/10.1007/s11010-011-0927-x DB - PRIME DP - Unbound Medicine ER -