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Propolis oil extract: quality analysis and evaluation of its antimicrobial activity.

Abstract

Designing propolis products for external use involves determining the optimal form of propolis for the introduction into dermatological pharmaceuticals and cosmetic preparations. As a potent ingredient, propolis oil extract from raw material harvested in Lithuania was analysed. The rheological characteristics, content of phenolic compounds, major compounds and antimicrobial activity of the propolis oil extract are investigated here for the first time. The propolis oil extract was produced by maceration using different solvents, raw material was collected in Lithuania. Solvent mixture with 96% ethanol increased the rheological stability and extracted amount of phenolic compound. High-performance liquid chromatography identified the potent quality markers for Lithuanian propolis, phenylpropanoid vanillin, coumaric acid and ferulic acid. Antimicrobial activity of propolis oil extract was evaluated in experimental studies in vitro, and the minimal concentration of phenolic compounds that inhibited respective microorganisms was determined. The results demonstrate that phenolic compounds have effective antimicrobial activity in propolis oil extract; thus, it can be compatible with the semisolid preparation.

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  • Authors+Show Affiliations

    ,

    Department of Pharmaceutical Technology and Social Pharmacy, Kaunas University of Medicine, A. Mickevičiaus 9, Kaunas 44307, Lithuania.

    Source

    Natural product research 25:15 2011 Sep pg 1463-8

    MeSH

    Anti-Infective Agents
    Candida albicans
    Chromatography, High Pressure Liquid
    Gram-Negative Bacteria
    Gram-Positive Bacteria
    Microbial Sensitivity Tests
    Oils
    Propolis

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21714730

    Citation

    Ramanauskienė, K, and A M. Inkėnienė. "Propolis Oil Extract: Quality Analysis and Evaluation of Its Antimicrobial Activity." Natural Product Research, vol. 25, no. 15, 2011, pp. 1463-8.
    Ramanauskienė K, Inkėnienė AM. Propolis oil extract: quality analysis and evaluation of its antimicrobial activity. Nat Prod Res. 2011;25(15):1463-8.
    Ramanauskienė, K., & Inkėnienė, A. M. (2011). Propolis oil extract: quality analysis and evaluation of its antimicrobial activity. Natural Product Research, 25(15), pp. 1463-8. doi:10.1080/14786419.2010.529440.
    Ramanauskienė K, Inkėnienė AM. Propolis Oil Extract: Quality Analysis and Evaluation of Its Antimicrobial Activity. Nat Prod Res. 2011;25(15):1463-8. PubMed PMID: 21714730.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Propolis oil extract: quality analysis and evaluation of its antimicrobial activity. AU - Ramanauskienė,K, AU - Inkėnienė,A M, Y1 - 2011/06/30/ PY - 2011/7/1/entrez PY - 2011/7/1/pubmed PY - 2012/1/4/medline SP - 1463 EP - 8 JF - Natural product research JO - Nat. Prod. Res. VL - 25 IS - 15 N2 - Designing propolis products for external use involves determining the optimal form of propolis for the introduction into dermatological pharmaceuticals and cosmetic preparations. As a potent ingredient, propolis oil extract from raw material harvested in Lithuania was analysed. The rheological characteristics, content of phenolic compounds, major compounds and antimicrobial activity of the propolis oil extract are investigated here for the first time. The propolis oil extract was produced by maceration using different solvents, raw material was collected in Lithuania. Solvent mixture with 96% ethanol increased the rheological stability and extracted amount of phenolic compound. High-performance liquid chromatography identified the potent quality markers for Lithuanian propolis, phenylpropanoid vanillin, coumaric acid and ferulic acid. Antimicrobial activity of propolis oil extract was evaluated in experimental studies in vitro, and the minimal concentration of phenolic compounds that inhibited respective microorganisms was determined. The results demonstrate that phenolic compounds have effective antimicrobial activity in propolis oil extract; thus, it can be compatible with the semisolid preparation. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/21714730/Propolis_oil_extract:_quality_analysis_and_evaluation_of_its_antimicrobial_activity_ L2 - http://www.tandfonline.com/doi/full/10.1080/14786419.2010.529440 DB - PRIME DP - Unbound Medicine ER -