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Low free testosterone levels are associated with all-cause and cardiovascular mortality in postmenopausal diabetic women.
Diabetes Care. 2011 Aug; 34(8):1771-7.DC

Abstract

OBJECTIVE

Hyperandrogenemia is associated with cardiovascular risk factors in women but evidence about the relationship of testosterone levels with mortality is sparse. We aimed to evaluate whether total testosterone (TT), free testosterone (FT), and sex hormone-binding globulin (SHBG) are associated with all-cause and cardiovascular mortality in a cohort of postmenopausal women.

RESEARCH DESIGN AND METHODS

We measured TT and SHBG levels in 875 postmenopausal women who were referred for coronary angiography (during 1997-2000). FT was calculated according to the Vermeulen method. The main outcome measures were Cox proportional hazard ratios (HRs) for mortality from all causes and from cardiovascular causes.

RESULTS

After a median follow-up time of 7.7 years, 179 women (20.5%) had died. There were 101 deaths due to cardiovascular disease (56.4% of all deaths). We found no association of FT, TT, and SHBG levels with mortality in all postmenopausal women. In postmenopausal diabetic women, multivariable-adjusted HRs (with 95% CIs) in the fourth compared with the first FT quartile for all-cause and cardiovascular mortality were 0.38 (0.08-0.90), P = 0.025, and 0.28 (0.08-0.90), P = 0.032, respectively. We found no association of TT and SHBG with mortality in diabetic postmenopausal women.

CONCLUSIONS

In postmenopausal diabetic women referred for coronary angiography, low FT levels are independently associated with increased all-cause and cardiovascular mortality.

Authors+Show Affiliations

Department of Internal Medicine, Medical UniversityGraz, Graz, Austria. elisabeth.wehr@medunigraz.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21715525

Citation

Wehr, Elisabeth, et al. "Low Free Testosterone Levels Are Associated With All-cause and Cardiovascular Mortality in Postmenopausal Diabetic Women." Diabetes Care, vol. 34, no. 8, 2011, pp. 1771-7.
Wehr E, Pilz S, Boehm BO, et al. Low free testosterone levels are associated with all-cause and cardiovascular mortality in postmenopausal diabetic women. Diabetes Care. 2011;34(8):1771-7.
Wehr, E., Pilz, S., Boehm, B. O., Grammer, T. B., März, W., & Obermayer-Pietsch, B. (2011). Low free testosterone levels are associated with all-cause and cardiovascular mortality in postmenopausal diabetic women. Diabetes Care, 34(8), 1771-7. https://doi.org/10.2337/dc11-0596
Wehr E, et al. Low Free Testosterone Levels Are Associated With All-cause and Cardiovascular Mortality in Postmenopausal Diabetic Women. Diabetes Care. 2011;34(8):1771-7. PubMed PMID: 21715525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low free testosterone levels are associated with all-cause and cardiovascular mortality in postmenopausal diabetic women. AU - Wehr,Elisabeth, AU - Pilz,Stefan, AU - Boehm,Bernhard O, AU - Grammer,Tanja B, AU - März,Winfried, AU - Obermayer-Pietsch,Barbara, Y1 - 2011/06/29/ PY - 2011/7/1/entrez PY - 2011/7/1/pubmed PY - 2012/1/20/medline SP - 1771 EP - 7 JF - Diabetes care JO - Diabetes Care VL - 34 IS - 8 N2 - OBJECTIVE: Hyperandrogenemia is associated with cardiovascular risk factors in women but evidence about the relationship of testosterone levels with mortality is sparse. We aimed to evaluate whether total testosterone (TT), free testosterone (FT), and sex hormone-binding globulin (SHBG) are associated with all-cause and cardiovascular mortality in a cohort of postmenopausal women. RESEARCH DESIGN AND METHODS: We measured TT and SHBG levels in 875 postmenopausal women who were referred for coronary angiography (during 1997-2000). FT was calculated according to the Vermeulen method. The main outcome measures were Cox proportional hazard ratios (HRs) for mortality from all causes and from cardiovascular causes. RESULTS: After a median follow-up time of 7.7 years, 179 women (20.5%) had died. There were 101 deaths due to cardiovascular disease (56.4% of all deaths). We found no association of FT, TT, and SHBG levels with mortality in all postmenopausal women. In postmenopausal diabetic women, multivariable-adjusted HRs (with 95% CIs) in the fourth compared with the first FT quartile for all-cause and cardiovascular mortality were 0.38 (0.08-0.90), P = 0.025, and 0.28 (0.08-0.90), P = 0.032, respectively. We found no association of TT and SHBG with mortality in diabetic postmenopausal women. CONCLUSIONS: In postmenopausal diabetic women referred for coronary angiography, low FT levels are independently associated with increased all-cause and cardiovascular mortality. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/21715525/Low_free_testosterone_levels_are_associated_with_all_cause_and_cardiovascular_mortality_in_postmenopausal_diabetic_women_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=21715525 DB - PRIME DP - Unbound Medicine ER -