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Significance of prediagnostic thyroid antibodies in women with autoimmune thyroid disease.
J Clin Endocrinol Metab 2011; 96(9):E1466-71JC

Abstract

INTRODUCTION

Antibodies to thyroglobulin (Tg), thyroperoxidase (TPO), and TSH receptor (TSH-R) are prevalent in autoimmune thyroid diseases. We aimed to assess whether females with Graves disease or Hashimoto thyroiditis are more likely than age-matched controls to have thyroid antibodies before clinical diagnosis and to measure the timing of antibody seroconversion.

METHODS

This was a nested case-control study using the Department of Defense Serum Repository and the Defense Medical Surveillance System, 1998-2007. We assessed thyroid antibodies in the serum of 522 female, active-duty, military personnel including: 87 Graves disease cases, 87 Hashimoto thyroiditis cases, and 348 age matched controls. One serum sample was available at the time of the clinical diagnosis (±6 months); three additional samples were retrieved from the repository up to 7 yr before the clinical diagnosis, for a total of 2088 samples.

RESULTS

In Hashimoto thyroiditis, TPO antibodies were found in about 66% of the cases at all time points. Tg antibodies showed a similar stationary trend, at a lower prevalence of about 53%at all time points. No TSH-R antibodies were found. In Graves disease, TPO antibodies gradually increased from 31% at 5-7 yr prior to diagnosis to 57% at diagnosis and Tg antibodies from 18 to 47%. TSH-R antibodies were present before diagnosis and showed an increasing prevalence from 2, 7, 20, to 55%.

CONCLUSIONS

Antibodies to Tg, TPO, and TSH-R precede by years the development of the diagnostic autoimmune thyroid diseases phenotype. Overall, the presence of thyroid antibodies in apparently healthy individuals should not be neglected.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland 21287, USA. shutfle1@jhmi.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21715532

Citation

Hutfless, Susan, et al. "Significance of Prediagnostic Thyroid Antibodies in Women With Autoimmune Thyroid Disease." The Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 9, 2011, pp. E1466-71.
Hutfless S, Matos P, Talor MV, et al. Significance of prediagnostic thyroid antibodies in women with autoimmune thyroid disease. J Clin Endocrinol Metab. 2011;96(9):E1466-71.
Hutfless, S., Matos, P., Talor, M. V., Caturegli, P., & Rose, N. R. (2011). Significance of prediagnostic thyroid antibodies in women with autoimmune thyroid disease. The Journal of Clinical Endocrinology and Metabolism, 96(9), pp. E1466-71. doi:10.1210/jc.2011-0228.
Hutfless S, et al. Significance of Prediagnostic Thyroid Antibodies in Women With Autoimmune Thyroid Disease. J Clin Endocrinol Metab. 2011;96(9):E1466-71. PubMed PMID: 21715532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significance of prediagnostic thyroid antibodies in women with autoimmune thyroid disease. AU - Hutfless,Susan, AU - Matos,Peter, AU - Talor,Monica V, AU - Caturegli,Patrizio, AU - Rose,Noel R, Y1 - 2011/06/29/ PY - 2011/7/1/entrez PY - 2011/7/1/pubmed PY - 2011/12/13/medline SP - E1466 EP - 71 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 96 IS - 9 N2 - INTRODUCTION: Antibodies to thyroglobulin (Tg), thyroperoxidase (TPO), and TSH receptor (TSH-R) are prevalent in autoimmune thyroid diseases. We aimed to assess whether females with Graves disease or Hashimoto thyroiditis are more likely than age-matched controls to have thyroid antibodies before clinical diagnosis and to measure the timing of antibody seroconversion. METHODS: This was a nested case-control study using the Department of Defense Serum Repository and the Defense Medical Surveillance System, 1998-2007. We assessed thyroid antibodies in the serum of 522 female, active-duty, military personnel including: 87 Graves disease cases, 87 Hashimoto thyroiditis cases, and 348 age matched controls. One serum sample was available at the time of the clinical diagnosis (±6 months); three additional samples were retrieved from the repository up to 7 yr before the clinical diagnosis, for a total of 2088 samples. RESULTS: In Hashimoto thyroiditis, TPO antibodies were found in about 66% of the cases at all time points. Tg antibodies showed a similar stationary trend, at a lower prevalence of about 53%at all time points. No TSH-R antibodies were found. In Graves disease, TPO antibodies gradually increased from 31% at 5-7 yr prior to diagnosis to 57% at diagnosis and Tg antibodies from 18 to 47%. TSH-R antibodies were present before diagnosis and showed an increasing prevalence from 2, 7, 20, to 55%. CONCLUSIONS: Antibodies to Tg, TPO, and TSH-R precede by years the development of the diagnostic autoimmune thyroid diseases phenotype. Overall, the presence of thyroid antibodies in apparently healthy individuals should not be neglected. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/21715532/Significance_of_prediagnostic_thyroid_antibodies_in_women_with_autoimmune_thyroid_disease_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2011-0228 DB - PRIME DP - Unbound Medicine ER -