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Combined effect of silica dust and tobacco smoking on mortality from chronic obstructive lung disease in gold miners.
Br J Ind Med 1990; 47(10):656-64BJ

Abstract

A sample of 2209 white South African gold miners aged 45-54 between 1968-71, who started mining exposure during 1936-43, was investigated from 1968-71 to 30 December 1986. The effect of silica dust and tobacco smoking on mortality from chronic obstructive lung disease (COLD) was assessed. The relative risk (RR) for dust exposure before 1950 was estimated as 2.5 (95% confidence interval (CI) 1.5-4.2), for 10 units of 1000 particle-years. The combined effect of dust exposure before 1950 and years of cigarette smoking on mortality from COLD was best estimated by the multiplicative model, indicating that the two exposures act synergistically. All those that died of the disease were smokers. According to the estimates of attributable risk about 5% of the deaths from COLD were from the effect of dust, 34% were from smoking, and 59% were from the combined effect of dust and smoking. In conclusion, the results indicate that workers exposed to silica dust who smoke are at higher risk of dying from COLD than smokers not exposed to silica dust, as the two exposures act synergistically in causing COLD.

Authors+Show Affiliations

Epidemiology Research Unit, Medical Bureau for Occupational Diseases, Johannesburg, South Africa.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2171628

Citation

Hnizdo, E. "Combined Effect of Silica Dust and Tobacco Smoking On Mortality From Chronic Obstructive Lung Disease in Gold Miners." British Journal of Industrial Medicine, vol. 47, no. 10, 1990, pp. 656-64.
Hnizdo E. Combined effect of silica dust and tobacco smoking on mortality from chronic obstructive lung disease in gold miners. Br J Ind Med. 1990;47(10):656-64.
Hnizdo, E. (1990). Combined effect of silica dust and tobacco smoking on mortality from chronic obstructive lung disease in gold miners. British Journal of Industrial Medicine, 47(10), pp. 656-64.
Hnizdo E. Combined Effect of Silica Dust and Tobacco Smoking On Mortality From Chronic Obstructive Lung Disease in Gold Miners. Br J Ind Med. 1990;47(10):656-64. PubMed PMID: 2171628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined effect of silica dust and tobacco smoking on mortality from chronic obstructive lung disease in gold miners. A1 - Hnizdo,E, PY - 1990/10/1/pubmed PY - 1990/10/1/medline PY - 1990/10/1/entrez SP - 656 EP - 64 JF - British journal of industrial medicine JO - Br J Ind Med VL - 47 IS - 10 N2 - A sample of 2209 white South African gold miners aged 45-54 between 1968-71, who started mining exposure during 1936-43, was investigated from 1968-71 to 30 December 1986. The effect of silica dust and tobacco smoking on mortality from chronic obstructive lung disease (COLD) was assessed. The relative risk (RR) for dust exposure before 1950 was estimated as 2.5 (95% confidence interval (CI) 1.5-4.2), for 10 units of 1000 particle-years. The combined effect of dust exposure before 1950 and years of cigarette smoking on mortality from COLD was best estimated by the multiplicative model, indicating that the two exposures act synergistically. All those that died of the disease were smokers. According to the estimates of attributable risk about 5% of the deaths from COLD were from the effect of dust, 34% were from smoking, and 59% were from the combined effect of dust and smoking. In conclusion, the results indicate that workers exposed to silica dust who smoke are at higher risk of dying from COLD than smokers not exposed to silica dust, as the two exposures act synergistically in causing COLD. SN - 0007-1072 UR - https://www.unboundmedicine.com/medline/citation/2171628/Combined_effect_of_silica_dust_and_tobacco_smoking_on_mortality_from_chronic_obstructive_lung_disease_in_gold_miners_ L2 - http://oem.bmj.com/cgi/pmidlookup?view=long&pmid=2171628 DB - PRIME DP - Unbound Medicine ER -