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Milk, dairy intake and risk of endometrial cancer: a 26-year follow-up.

Abstract

Estrogens have a central role in the etiology of endometrial cancer. Milk and dairy products are a source of steroid hormones and growth factors that might have physiological effects in humans. We hypothesized that high intakes of milk and dairy products are associated with an increased risk of endometrial cancer, particularly among postmenopausal women not using hormone therapy. This was a prospective cohort study with 68,019 female participants in the Nurses' Health Study aged 34-59 in 1980. Milk and dairy consumption were assessed in 1980, 1984, 1986, 1990, 1994, 1998 and 2002 as servings per day and the follow-up continued through 2006. The multivariate relative risks (RRs) of adenocarcinoma of the endometrium across categories of cumulatively averaged total dairy consumption compared with < 1 svg/day were: 0.94 (95% CI = 0.71-1.25) for 1-1.4 svg/day, 1.14 (0.87-1.49) for 1.5-1.9 svg/day, 1.10 (0.84-1.44) for 2-2.9 svg/day, 1.26 (0.94-1.70) for ≥ 3 svg/day (p for trend = 0.06). The association between total dairy intake and endometrial cancer was significant only among the postmenopausal women (for ≥ 3 svg/day RR = 1.41, 95% CI = 1.01-1.98, p for trend = 0.02) and was evident only among those who were not currently using hormone therapy (RR = 1.58, 95% CI = 1.05-2.36, p for trend = 0.003). Total dairy intake was not significantly associated with risk of preinvasive endometrial cancer. In conclusion, we observed a marginally significant overall association between dairy intake and endometrial cancer and a stronger association among postmenopausal women who were not using estrogen-containing hormones.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. gdavaasa@hsph.harvard.edu

    , , ,

    Source

    International journal of cancer 130:11 2012 Jun 01 pg 2664-71

    MeSH

    Adult
    Animals
    Body Mass Index
    Cattle
    Cohort Studies
    Dairy Products
    Endometrial Neoplasms
    Female
    Follow-Up Studies
    Humans
    Middle Aged
    Milk
    Multivariate Analysis
    Prospective Studies
    Risk
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21717454

    Citation

    Ganmaa, Davaasambuu, et al. "Milk, Dairy Intake and Risk of Endometrial Cancer: a 26-year Follow-up." International Journal of Cancer, vol. 130, no. 11, 2012, pp. 2664-71.
    Ganmaa D, Cui X, Feskanich D, et al. Milk, dairy intake and risk of endometrial cancer: a 26-year follow-up. Int J Cancer. 2012;130(11):2664-71.
    Ganmaa, D., Cui, X., Feskanich, D., Hankinson, S. E., & Willett, W. C. (2012). Milk, dairy intake and risk of endometrial cancer: a 26-year follow-up. International Journal of Cancer, 130(11), pp. 2664-71. doi:10.1002/ijc.26265.
    Ganmaa D, et al. Milk, Dairy Intake and Risk of Endometrial Cancer: a 26-year Follow-up. Int J Cancer. 2012 Jun 1;130(11):2664-71. PubMed PMID: 21717454.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Milk, dairy intake and risk of endometrial cancer: a 26-year follow-up. AU - Ganmaa,Davaasambuu, AU - Cui,Xiaohui, AU - Feskanich,Diane, AU - Hankinson,Susan E, AU - Willett,Walter C, Y1 - 2011/09/17/ PY - 2011/01/28/received PY - 2011/06/03/accepted PY - 2011/7/1/entrez PY - 2011/7/1/pubmed PY - 2012/5/12/medline SP - 2664 EP - 71 JF - International journal of cancer JO - Int. J. Cancer VL - 130 IS - 11 N2 - Estrogens have a central role in the etiology of endometrial cancer. Milk and dairy products are a source of steroid hormones and growth factors that might have physiological effects in humans. We hypothesized that high intakes of milk and dairy products are associated with an increased risk of endometrial cancer, particularly among postmenopausal women not using hormone therapy. This was a prospective cohort study with 68,019 female participants in the Nurses' Health Study aged 34-59 in 1980. Milk and dairy consumption were assessed in 1980, 1984, 1986, 1990, 1994, 1998 and 2002 as servings per day and the follow-up continued through 2006. The multivariate relative risks (RRs) of adenocarcinoma of the endometrium across categories of cumulatively averaged total dairy consumption compared with < 1 svg/day were: 0.94 (95% CI = 0.71-1.25) for 1-1.4 svg/day, 1.14 (0.87-1.49) for 1.5-1.9 svg/day, 1.10 (0.84-1.44) for 2-2.9 svg/day, 1.26 (0.94-1.70) for ≥ 3 svg/day (p for trend = 0.06). The association between total dairy intake and endometrial cancer was significant only among the postmenopausal women (for ≥ 3 svg/day RR = 1.41, 95% CI = 1.01-1.98, p for trend = 0.02) and was evident only among those who were not currently using hormone therapy (RR = 1.58, 95% CI = 1.05-2.36, p for trend = 0.003). Total dairy intake was not significantly associated with risk of preinvasive endometrial cancer. In conclusion, we observed a marginally significant overall association between dairy intake and endometrial cancer and a stronger association among postmenopausal women who were not using estrogen-containing hormones. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/21717454/full_citation L2 - https://doi.org/10.1002/ijc.26265 DB - PRIME DP - Unbound Medicine ER -