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Pre-emptive intrathecal quinidine alleviates spinal nerve ligation-induced peripheral neuropathic pain.
J Pharm Pharmacol. 2011 Aug; 63(8):1063-9.JP

Abstract

OBJECTIVES

Quinidine, a class I anti-arrhythmic agent, is a sodium channel blocker that is more potent than lidocaine and mexiletine. This study tested pre-emptive intrathecal quinidine to attenuate neuropathic pain induced by lumbar spinal nerve ligation (SNL).

METHODS

Ninety-six adult male Sprague-Dawley rats were grouped equally (n=24 per group) as follows: group S (sham), removal of transverse process only; group L, SNL; group Q₃₅, SNL pretreated with intrathecal quinidine 35 mM (50 µl); group Q₇₀, SNL pretreated with intrathecal quinidine 70 mM (50 µl). Neuropathic pain was measured by thermal hyperalgesia and mechanical allodynia. Other measurements included dys-regulation of sodium channel Nav₁.₃ in dorsal root ganglion (DRG) and spinal microglia activation in spinal dorsal horn.

KEY FINDINGS

Spinal nerve ligation induced abnormal mechanical allodynia and thermal hyperalgesia, up-regulated Nav₁.₃ in DRG, and activated microglia in spinal cord. Group Q₇₀ showed attenuated thermal hyperalgesia (P<0.001) and mechanical allodynia (P<0.05) on postoperative day 5 (POD₅) but not on POD₇, reversed up-regulated expression of Nav₁.₃ on POD₃ and POD₇ in DRG and significantly attenuated microglia activation on POD₇ (P=0.032) in spinal cord.

CONCLUSIONS

Pretreatment with intrathecal quinidine 70 mM before SNL attenuates nerve ligation-induced neuropathic pain. The duration of the effect is 5 days.

Authors+Show Affiliations

Graduate Institute of Medicine, Department of Anesthesiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21718290

Citation

Cheng, Kuang-I, et al. "Pre-emptive Intrathecal Quinidine Alleviates Spinal Nerve Ligation-induced Peripheral Neuropathic Pain." The Journal of Pharmacy and Pharmacology, vol. 63, no. 8, 2011, pp. 1063-9.
Cheng KI, Wang HC, Lai CS, et al. Pre-emptive intrathecal quinidine alleviates spinal nerve ligation-induced peripheral neuropathic pain. J Pharm Pharmacol. 2011;63(8):1063-9.
Cheng, K. I., Wang, H. C., Lai, C. S., Tsai, H. P., Kwan, A. L., Ho, S. T., Wang, J. J., & Chang, L. L. (2011). Pre-emptive intrathecal quinidine alleviates spinal nerve ligation-induced peripheral neuropathic pain. The Journal of Pharmacy and Pharmacology, 63(8), 1063-9. https://doi.org/10.1111/j.2042-7158.2011.01318.x
Cheng KI, et al. Pre-emptive Intrathecal Quinidine Alleviates Spinal Nerve Ligation-induced Peripheral Neuropathic Pain. J Pharm Pharmacol. 2011;63(8):1063-9. PubMed PMID: 21718290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-emptive intrathecal quinidine alleviates spinal nerve ligation-induced peripheral neuropathic pain. AU - Cheng,Kuang-I, AU - Wang,Hung-Chen, AU - Lai,Chung-Sheng, AU - Tsai,Hung-Pei, AU - Kwan,Aij-Lie, AU - Ho,Shung-Tai, AU - Wang,Jhi-Joung, AU - Chang,Lin-Li, Y1 - 2011/06/11/ PY - 2011/7/2/entrez PY - 2011/7/2/pubmed PY - 2012/1/10/medline SP - 1063 EP - 9 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 63 IS - 8 N2 - OBJECTIVES: Quinidine, a class I anti-arrhythmic agent, is a sodium channel blocker that is more potent than lidocaine and mexiletine. This study tested pre-emptive intrathecal quinidine to attenuate neuropathic pain induced by lumbar spinal nerve ligation (SNL). METHODS: Ninety-six adult male Sprague-Dawley rats were grouped equally (n=24 per group) as follows: group S (sham), removal of transverse process only; group L, SNL; group Q₃₅, SNL pretreated with intrathecal quinidine 35 mM (50 µl); group Q₇₀, SNL pretreated with intrathecal quinidine 70 mM (50 µl). Neuropathic pain was measured by thermal hyperalgesia and mechanical allodynia. Other measurements included dys-regulation of sodium channel Nav₁.₃ in dorsal root ganglion (DRG) and spinal microglia activation in spinal dorsal horn. KEY FINDINGS: Spinal nerve ligation induced abnormal mechanical allodynia and thermal hyperalgesia, up-regulated Nav₁.₃ in DRG, and activated microglia in spinal cord. Group Q₇₀ showed attenuated thermal hyperalgesia (P<0.001) and mechanical allodynia (P<0.05) on postoperative day 5 (POD₅) but not on POD₇, reversed up-regulated expression of Nav₁.₃ on POD₃ and POD₇ in DRG and significantly attenuated microglia activation on POD₇ (P=0.032) in spinal cord. CONCLUSIONS: Pretreatment with intrathecal quinidine 70 mM before SNL attenuates nerve ligation-induced neuropathic pain. The duration of the effect is 5 days. SN - 2042-7158 UR - https://www.unboundmedicine.com/medline/citation/21718290/Pre_emptive_intrathecal_quinidine_alleviates_spinal_nerve_ligation_induced_peripheral_neuropathic_pain_ L2 - https://doi.org/10.1111/j.2042-7158.2011.01318.x DB - PRIME DP - Unbound Medicine ER -