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Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models.
J Pharm Pharmacol. 2011 Aug; 63(8):1070-7.JP

Abstract

OBJECTIVES

Friedelin was isolated from Azima tetracantha Lam. leaves collected from Kallakurichi, Villuppuram district, Tamil Nadu, India. The anti-inflammatory, analgesic and antipyretic activities of friedelin have been investigated in Wistar rats and mice.

METHODS

Friedelin was isolated from the hexane extract of leaves of A. tetracantha using column chromatography. The effects of friedelin on inflammation were studied by using carrageenan-induced hind paw oedema, croton oil-induced ear oedema, acetic acid-induced vascular permeability, cotton pellet-induced granuloma and adjuvant-induced arthritis. The analgesic effect of friedelin was evaluated using the acetic acid-induced abdominal constriction response, formalin-induced paw licking response and the hot-plate test. The antipyretic effect of friedelin was evaluated using the yeast-induced hyperthermia test in rats.

KEY FINDINGS

In the acute phase of inflammation, maximum inhibitions of 52.5 and 68.7% (P<0.05) were noted with 40 mg/kg friedelin in carrageenan-induced paw oedema and croton oil-induced ear oedema, respectively. Administration of friedelin (40 mg/kg) significantly (P<0.05) decreased the formation of granuloma tissue induced by cotton pellet at a rate of 36.3%. In the adjuvant-induced arthritis test friedelin inhibited 54.5% of paw thickness. Friedelin inhibited acetic acid-induced vascular permeability in mice. Friedelin also produced significant (P<0.05) analgesic activity in the acetic acid-induced abdominal constriction response and formalin-induced paw licking response. In the hot-plate test, friedelin did not show any significant results when compared with control. Treatment with friedelin showed a significant (P<0.05) dose-dependent reduction in pyrexia in rats.

CONCLUSIONS

The results suggested that friedelin possessed potent anti-inflammatory, analgesic and antipyretic activities.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Antonisamy P
Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai, Tamil Nadu, India.
Duraipandiyan V
No affiliation info available
Ignacimuthu S
No affiliation info available

MeSH

Abdominal PainAnalgesicsAnimalsAnti-Inflammatory AgentsAntipyreticsArthritis, ExperimentalBehavior, AnimalCapillary PermeabilityDose-Response Relationship, DrugEarEdemaFemaleFeverFootGranulomaMaleMicePhytotherapyPlant ExtractsPlant LeavesRatsRats, WistarSalvadoraceaeTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21718291

Citation

Antonisamy, Paulrayer, et al. "Anti-inflammatory, Analgesic and Antipyretic Effects of Friedelin Isolated From Azima Tetracantha Lam. in Mouse and Rat Models." The Journal of Pharmacy and Pharmacology, vol. 63, no. 8, 2011, pp. 1070-7.
Antonisamy P, Duraipandiyan V, Ignacimuthu S. Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models. J Pharm Pharmacol. 2011;63(8):1070-7.
Antonisamy, P., Duraipandiyan, V., & Ignacimuthu, S. (2011). Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models. The Journal of Pharmacy and Pharmacology, 63(8), 1070-7. https://doi.org/10.1111/j.2042-7158.2011.01300.x
Antonisamy P, Duraipandiyan V, Ignacimuthu S. Anti-inflammatory, Analgesic and Antipyretic Effects of Friedelin Isolated From Azima Tetracantha Lam. in Mouse and Rat Models. J Pharm Pharmacol. 2011;63(8):1070-7. PubMed PMID: 21718291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models. AU - Antonisamy,Paulrayer, AU - Duraipandiyan,Veeramuthu, AU - Ignacimuthu,Savarimuthu, Y1 - 2011/06/11/ PY - 2011/7/2/entrez PY - 2011/7/2/pubmed PY - 2012/1/10/medline SP - 1070 EP - 7 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 63 IS - 8 N2 - OBJECTIVES: Friedelin was isolated from Azima tetracantha Lam. leaves collected from Kallakurichi, Villuppuram district, Tamil Nadu, India. The anti-inflammatory, analgesic and antipyretic activities of friedelin have been investigated in Wistar rats and mice. METHODS: Friedelin was isolated from the hexane extract of leaves of A. tetracantha using column chromatography. The effects of friedelin on inflammation were studied by using carrageenan-induced hind paw oedema, croton oil-induced ear oedema, acetic acid-induced vascular permeability, cotton pellet-induced granuloma and adjuvant-induced arthritis. The analgesic effect of friedelin was evaluated using the acetic acid-induced abdominal constriction response, formalin-induced paw licking response and the hot-plate test. The antipyretic effect of friedelin was evaluated using the yeast-induced hyperthermia test in rats. KEY FINDINGS: In the acute phase of inflammation, maximum inhibitions of 52.5 and 68.7% (P<0.05) were noted with 40 mg/kg friedelin in carrageenan-induced paw oedema and croton oil-induced ear oedema, respectively. Administration of friedelin (40 mg/kg) significantly (P<0.05) decreased the formation of granuloma tissue induced by cotton pellet at a rate of 36.3%. In the adjuvant-induced arthritis test friedelin inhibited 54.5% of paw thickness. Friedelin inhibited acetic acid-induced vascular permeability in mice. Friedelin also produced significant (P<0.05) analgesic activity in the acetic acid-induced abdominal constriction response and formalin-induced paw licking response. In the hot-plate test, friedelin did not show any significant results when compared with control. Treatment with friedelin showed a significant (P<0.05) dose-dependent reduction in pyrexia in rats. CONCLUSIONS: The results suggested that friedelin possessed potent anti-inflammatory, analgesic and antipyretic activities. SN - 2042-7158 UR - https://www.unboundmedicine.com/medline/citation/21718291/Anti_inflammatory_analgesic_and_antipyretic_effects_of_friedelin_isolated_from_Azima_tetracantha_Lam__in_mouse_and_rat_models_ DB - PRIME DP - Unbound Medicine ER -