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Anti-diabetic activity and potential mechanism of total flavonoids of Selaginella tamariscina (Beauv.) Spring in rats induced by high fat diet and low dose STZ.
J Ethnopharmacol. 2011 Sep 01; 137(1):662-8.JE

Abstract

AIM OF THE STUDY

To evaluate the anti-diabetic effects of the total flavonoids of Selaginella tamariscina (Beauv.) Spring (TFST), and to explore the pertinent mechanism.

MATERIALS AND METHODS

High fat diet and STZ (35 mg/kg) induced diabetic rats were administered with TFST at graded oral doses (100, 200 and 400mg/kg/day, ig.) for 8 weeks. A range of parameters, including blood glucose and lipid, serum insulin and glucagon, glucose tolerance, were tested to evaluate its anti-diabetic effects. The determination of protein expression of peroxisome proliferator activated receptor γ (PPAR-γ) in adipose tissue and insulin receptor substrate 1 (IRS-1) in hepatic and skeletal muscle tissues was used to study the mechanism of TFST. Moreover, the preliminary study of TFST on the antioxidant activity was performed.

RESULTS

The TFST possessed anti-diabetic activities as shown by the decreased serum levels of fast blood glucose (FBG), glycosylated hemoglobulin A1C (HbA1c), triglyceride (TG), total cholesterol (TC), free fatty acid (FFA), low density lipoprotein-cholesterol (LDL-C) and glucagon, as well as increased serum levels of high density lipoprotein-cholesterol (HDL-C), insulin and C-peptide. TFST also improved the oral glucose tolerance test (OGTT) to a certain degree. Furthermore, TFST increased the protein expression of PPAR-γ in adipose tissue, and increased the protein expressions of IRS-1 in hepatic and skeletal muscle tissues. These benefits were associated with increased superoxide dismutase (SOD) and decreased malondialdehyde (MDA) in serum.

CONCLUSIONS

TFST exert beneficial effects on hyperglycosemia and hyperlipoidemia in diabetic rats possibly through regulating the levers of PPAR-γ in adipose tissue and IRS-1 in hepatic and skeletal muscle tissues.

Authors+Show Affiliations

Henan University of Traditional Chinese Medicine, Zhengzhou 450008, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21718776

Citation

Zheng, Xiao-Ke, et al. "Anti-diabetic Activity and Potential Mechanism of Total Flavonoids of Selaginella Tamariscina (Beauv.) Spring in Rats Induced By High Fat Diet and Low Dose STZ." Journal of Ethnopharmacology, vol. 137, no. 1, 2011, pp. 662-8.
Zheng XK, Zhang L, Wang WW, et al. Anti-diabetic activity and potential mechanism of total flavonoids of Selaginella tamariscina (Beauv.) Spring in rats induced by high fat diet and low dose STZ. J Ethnopharmacol. 2011;137(1):662-8.
Zheng, X. K., Zhang, L., Wang, W. W., Wu, Y. Y., Zhang, Q. B., & Feng, W. S. (2011). Anti-diabetic activity and potential mechanism of total flavonoids of Selaginella tamariscina (Beauv.) Spring in rats induced by high fat diet and low dose STZ. Journal of Ethnopharmacology, 137(1), 662-8. https://doi.org/10.1016/j.jep.2011.06.018
Zheng XK, et al. Anti-diabetic Activity and Potential Mechanism of Total Flavonoids of Selaginella Tamariscina (Beauv.) Spring in Rats Induced By High Fat Diet and Low Dose STZ. J Ethnopharmacol. 2011 Sep 1;137(1):662-8. PubMed PMID: 21718776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-diabetic activity and potential mechanism of total flavonoids of Selaginella tamariscina (Beauv.) Spring in rats induced by high fat diet and low dose STZ. AU - Zheng,Xiao-Ke, AU - Zhang,Li, AU - Wang,Wei-Wei, AU - Wu,Yong-Yong, AU - Zhang,Qiu-Bo, AU - Feng,Wei-Sheng, Y1 - 2011/06/28/ PY - 2010/11/18/received PY - 2011/05/08/revised PY - 2011/06/11/accepted PY - 2011/7/2/entrez PY - 2011/7/2/pubmed PY - 2011/12/28/medline SP - 662 EP - 8 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 137 IS - 1 N2 - AIM OF THE STUDY: To evaluate the anti-diabetic effects of the total flavonoids of Selaginella tamariscina (Beauv.) Spring (TFST), and to explore the pertinent mechanism. MATERIALS AND METHODS: High fat diet and STZ (35 mg/kg) induced diabetic rats were administered with TFST at graded oral doses (100, 200 and 400mg/kg/day, ig.) for 8 weeks. A range of parameters, including blood glucose and lipid, serum insulin and glucagon, glucose tolerance, were tested to evaluate its anti-diabetic effects. The determination of protein expression of peroxisome proliferator activated receptor γ (PPAR-γ) in adipose tissue and insulin receptor substrate 1 (IRS-1) in hepatic and skeletal muscle tissues was used to study the mechanism of TFST. Moreover, the preliminary study of TFST on the antioxidant activity was performed. RESULTS: The TFST possessed anti-diabetic activities as shown by the decreased serum levels of fast blood glucose (FBG), glycosylated hemoglobulin A1C (HbA1c), triglyceride (TG), total cholesterol (TC), free fatty acid (FFA), low density lipoprotein-cholesterol (LDL-C) and glucagon, as well as increased serum levels of high density lipoprotein-cholesterol (HDL-C), insulin and C-peptide. TFST also improved the oral glucose tolerance test (OGTT) to a certain degree. Furthermore, TFST increased the protein expression of PPAR-γ in adipose tissue, and increased the protein expressions of IRS-1 in hepatic and skeletal muscle tissues. These benefits were associated with increased superoxide dismutase (SOD) and decreased malondialdehyde (MDA) in serum. CONCLUSIONS: TFST exert beneficial effects on hyperglycosemia and hyperlipoidemia in diabetic rats possibly through regulating the levers of PPAR-γ in adipose tissue and IRS-1 in hepatic and skeletal muscle tissues. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21718776/Anti_diabetic_activity_and_potential_mechanism_of_total_flavonoids_of_Selaginella_tamariscina__Beauv___Spring_in_rats_induced_by_high_fat_diet_and_low_dose_STZ_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00435-1 DB - PRIME DP - Unbound Medicine ER -