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Enhanced diagnosis of pollen allergy using specific immunoglobulin E determination to detect major allergens and panallergens.
J Investig Allergol Clin Immunol. 2011; 21(4):253-9.JI

Abstract

BACKGROUND

Pollen is one of the main causes of allergic sensitization. It is not easy to make an etiological diagnosis of pollen-allergic patients because of the wide variety of sensitizing pollens, association with food allergy, and increasing incidence of polysensitization, which may result from the presence of allergens that are common to different species, as is the case of panallergens.

OBJECTIVE

To compare the results of skin prick tests (SPT) using whole pollen extract with specific immunoglobulin (Ig) E determination for several allergens (purified panallergens included) in the diagnosis of polysensitized pollen-allergic patients.

METHODS

The study sample comprised 179 pollen-sensitized patients who underwent SPT with pollen extract and allergen-specific IgE determination against different allergens.

RESULTS

The level of concordance between the traditional diagnostic test (SPT) and IgE determination was low, especially in patients sensitized to the panallergens profilin and polcalcin. In the case of SPT, the results demonstrated that patients who are sensitized to either of these panallergens present a significantly higher number of positive results than patients who are not. However, IgE determination revealed that while patients sensitized to polcalcins are sensitized to allergens from a higher number of pollens than the rest of the sample, this is not the case in patients sensitized to profilins. On the other hand, sensitization to profilin or lipid transfer proteins was clearly associated with food allergy.

CONCLUSIONS

Sensitization to panallergens could be a confounding factor in the diagnosis of polysensitized pollen-allergic patients as well as a marker for food allergy. However, more studies are required to further investigate the role of these molecules.

Authors+Show Affiliations

Regional Department of Immunology and Allergy, Hospital Universitario Virgen Macarena, Sevilla, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

21721370

Citation

Orovitg, A, et al. "Enhanced Diagnosis of Pollen Allergy Using Specific Immunoglobulin E Determination to Detect Major Allergens and Panallergens." Journal of Investigational Allergology & Clinical Immunology, vol. 21, no. 4, 2011, pp. 253-9.
Orovitg A, Guardia P, Barber D, et al. Enhanced diagnosis of pollen allergy using specific immunoglobulin E determination to detect major allergens and panallergens. J Investig Allergol Clin Immunol. 2011;21(4):253-9.
Orovitg, A., Guardia, P., Barber, D., de la Torre, F., Rodríguez, R., Villalba, M., Salcedo, G., Monteseirìn, J., & Conde, J. (2011). Enhanced diagnosis of pollen allergy using specific immunoglobulin E determination to detect major allergens and panallergens. Journal of Investigational Allergology & Clinical Immunology, 21(4), 253-9.
Orovitg A, et al. Enhanced Diagnosis of Pollen Allergy Using Specific Immunoglobulin E Determination to Detect Major Allergens and Panallergens. J Investig Allergol Clin Immunol. 2011;21(4):253-9. PubMed PMID: 21721370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced diagnosis of pollen allergy using specific immunoglobulin E determination to detect major allergens and panallergens. AU - Orovitg,A, AU - Guardia,P, AU - Barber,D, AU - de la Torre,F, AU - Rodríguez,R, AU - Villalba,M, AU - Salcedo,G, AU - Monteseirìn,J, AU - Conde,J, PY - 2011/7/5/entrez PY - 2011/7/5/pubmed PY - 2011/8/5/medline SP - 253 EP - 9 JF - Journal of investigational allergology & clinical immunology JO - J Investig Allergol Clin Immunol VL - 21 IS - 4 N2 - BACKGROUND: Pollen is one of the main causes of allergic sensitization. It is not easy to make an etiological diagnosis of pollen-allergic patients because of the wide variety of sensitizing pollens, association with food allergy, and increasing incidence of polysensitization, which may result from the presence of allergens that are common to different species, as is the case of panallergens. OBJECTIVE: To compare the results of skin prick tests (SPT) using whole pollen extract with specific immunoglobulin (Ig) E determination for several allergens (purified panallergens included) in the diagnosis of polysensitized pollen-allergic patients. METHODS: The study sample comprised 179 pollen-sensitized patients who underwent SPT with pollen extract and allergen-specific IgE determination against different allergens. RESULTS: The level of concordance between the traditional diagnostic test (SPT) and IgE determination was low, especially in patients sensitized to the panallergens profilin and polcalcin. In the case of SPT, the results demonstrated that patients who are sensitized to either of these panallergens present a significantly higher number of positive results than patients who are not. However, IgE determination revealed that while patients sensitized to polcalcins are sensitized to allergens from a higher number of pollens than the rest of the sample, this is not the case in patients sensitized to profilins. On the other hand, sensitization to profilin or lipid transfer proteins was clearly associated with food allergy. CONCLUSIONS: Sensitization to panallergens could be a confounding factor in the diagnosis of polysensitized pollen-allergic patients as well as a marker for food allergy. However, more studies are required to further investigate the role of these molecules. SN - 1018-9068 UR - https://www.unboundmedicine.com/medline/citation/21721370/Enhanced_diagnosis_of_pollen_allergy_using_specific_immunoglobulin_E_determination_to_detect_major_allergens_and_panallergens_ L2 - http://www.jiaci.org/issues/vol21issue4/vol21issue04-1.htm DB - PRIME DP - Unbound Medicine ER -