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Performance of Leptospira immunoglobulin M ELISA and rapid immunoglobulin G immunochromatographic assays for the diagnosis of leptospirosis.
J Med Assoc Thai. 2011 Feb; 94 Suppl 1:S203-6.JM

Abstract

Using archived samples, we assessed the diagnostic capacity of two commercially available tests (an ELISA IgM and a rapid immunochromatographic test, ICT) for the detection of Leptospira spp. IgM and IgG antibodies to aid with the diagnosis of acute leptospirosis in febrile patients in Thailand. The sensitivities of the ELISA for the detection of IgM and the rapid immunochromatographic test for the detection of IgG were 60.7% (95% CI, 50.3 to 70.2%), and 83.2% (95% CI 73.9 to 89.6%) respectively. False positive ICT result occurred in one patient with influenza B infection. The positive rates of both assays were high after the first week of onset of fever up to third weeks of illness.

Authors+Show Affiliations

Department ofMedicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21721448

Citation

Silpasakorn, Saowaluk, et al. "Performance of Leptospira Immunoglobulin M ELISA and Rapid Immunoglobulin G Immunochromatographic Assays for the Diagnosis of Leptospirosis." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 94 Suppl 1, 2011, pp. S203-6.
Silpasakorn S, Waywa D, Hoontrakul S, et al. Performance of Leptospira immunoglobulin M ELISA and rapid immunoglobulin G immunochromatographic assays for the diagnosis of leptospirosis. J Med Assoc Thai. 2011;94 Suppl 1:S203-6.
Silpasakorn, S., Waywa, D., Hoontrakul, S., Suttinont, C., Losuwanaluk, K., & Suputtamongkol, Y. (2011). Performance of Leptospira immunoglobulin M ELISA and rapid immunoglobulin G immunochromatographic assays for the diagnosis of leptospirosis. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 94 Suppl 1, S203-6.
Silpasakorn S, et al. Performance of Leptospira Immunoglobulin M ELISA and Rapid Immunoglobulin G Immunochromatographic Assays for the Diagnosis of Leptospirosis. J Med Assoc Thai. 2011;94 Suppl 1:S203-6. PubMed PMID: 21721448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Performance of Leptospira immunoglobulin M ELISA and rapid immunoglobulin G immunochromatographic assays for the diagnosis of leptospirosis. AU - Silpasakorn,Saowaluk, AU - Waywa,Duangdao, AU - Hoontrakul,Siriwan, AU - Suttinont,Chuanpit, AU - Losuwanaluk,Kitti, AU - Suputtamongkol,Yupin, PY - 2011/7/5/entrez PY - 2011/7/5/pubmed PY - 2011/10/26/medline SP - S203 EP - 6 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 94 Suppl 1 N2 - Using archived samples, we assessed the diagnostic capacity of two commercially available tests (an ELISA IgM and a rapid immunochromatographic test, ICT) for the detection of Leptospira spp. IgM and IgG antibodies to aid with the diagnosis of acute leptospirosis in febrile patients in Thailand. The sensitivities of the ELISA for the detection of IgM and the rapid immunochromatographic test for the detection of IgG were 60.7% (95% CI, 50.3 to 70.2%), and 83.2% (95% CI 73.9 to 89.6%) respectively. False positive ICT result occurred in one patient with influenza B infection. The positive rates of both assays were high after the first week of onset of fever up to third weeks of illness. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/21721448/Performance_of_Leptospira_immunoglobulin_M_ELISA_and_rapid_immunoglobulin_G_immunochromatographic_assays_for_the_diagnosis_of_leptospirosis_ L2 - http://www.diseaseinfosearch.org/result/4178 DB - PRIME DP - Unbound Medicine ER -