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Lower serum paraoxonase-1 activity is related to higher serum amyloid a levels in metabolic syndrome.
Arch Med Res. 2011 Apr; 42(3):219-25.AM

Abstract

BACKGROUND AND AIMS

High-density lipoproteins (HDL) contain the anti-oxidative enzyme, paraoxonase-1 (PON-1), which is important for atheroprotection. The acute phase reactant, serum amyloid A (SAA), an HDL-associated apolipoprotein, may impair PON-1 activity, whereas SAA and PON-1 are reciprocally regulated in response to acute inflammatory stimuli. The relationship of serum PON-1 activity with SAA during low-grade chronic inflammation is unclear. Here we tested the extent to which low serum PON-1 activity is related to high SAA levels in subjects with and without metabolic syndrome (MetS).

METHODS

In 19 nondiabetic subjects with MetS and 67 subjects without MetS, serum PON-1, assayed as its arylesterase activity, and SAA were measured together with plasma lipids and lipoproteins, high-sensitive C-reactive protein (hs-CRP) and insulin resistance (homeostasis model assessment (HOMA(ir)).

RESULTS

PON-1 activity was decreased (p=0.023), whereas SAA levels were increased (p=0.042) in MetS subjects, coinciding with higher hs-CRP levels and HOMA(ir) values. Multiple linear regression analysis revealed that age- and gender-adjusted PON-1 activity was related inversely to SAA (β=-0.256, p=0.020) after adjustment for MetS, or alternatively for hs-CRP and HOMA(ir) (β=-0.271, p=0.049).

CONCLUSIONS

Decreased serum PON-1 activity in MetS may in part be attributable to higher SAA levels. We suggest that higher SAA levels contribute to impaired HDL anti-oxidative function in MetS via an effect on PON-1 regulation.

Authors+Show Affiliations

Department of Endocrinology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21722818

Citation

Kappelle, Paul Jan Willem Herman, et al. "Lower Serum Paraoxonase-1 Activity Is Related to Higher Serum Amyloid a Levels in Metabolic Syndrome." Archives of Medical Research, vol. 42, no. 3, 2011, pp. 219-25.
Kappelle PJ, Bijzet J, Hazenberg BP, et al. Lower serum paraoxonase-1 activity is related to higher serum amyloid a levels in metabolic syndrome. Arch Med Res. 2011;42(3):219-25.
Kappelle, P. J., Bijzet, J., Hazenberg, B. P., & Dullaart, R. P. (2011). Lower serum paraoxonase-1 activity is related to higher serum amyloid a levels in metabolic syndrome. Archives of Medical Research, 42(3), 219-25. https://doi.org/10.1016/j.arcmed.2011.05.002
Kappelle PJ, et al. Lower Serum Paraoxonase-1 Activity Is Related to Higher Serum Amyloid a Levels in Metabolic Syndrome. Arch Med Res. 2011;42(3):219-25. PubMed PMID: 21722818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lower serum paraoxonase-1 activity is related to higher serum amyloid a levels in metabolic syndrome. AU - Kappelle,Paul Jan Willem Herman, AU - Bijzet,Johan, AU - Hazenberg,Bouke Pier, AU - Dullaart,Robin Pieter Frank, PY - 2010/12/18/received PY - 2011/05/04/accepted PY - 2011/7/5/entrez PY - 2011/7/5/pubmed PY - 2011/11/1/medline SP - 219 EP - 25 JF - Archives of medical research JO - Arch Med Res VL - 42 IS - 3 N2 - BACKGROUND AND AIMS: High-density lipoproteins (HDL) contain the anti-oxidative enzyme, paraoxonase-1 (PON-1), which is important for atheroprotection. The acute phase reactant, serum amyloid A (SAA), an HDL-associated apolipoprotein, may impair PON-1 activity, whereas SAA and PON-1 are reciprocally regulated in response to acute inflammatory stimuli. The relationship of serum PON-1 activity with SAA during low-grade chronic inflammation is unclear. Here we tested the extent to which low serum PON-1 activity is related to high SAA levels in subjects with and without metabolic syndrome (MetS). METHODS: In 19 nondiabetic subjects with MetS and 67 subjects without MetS, serum PON-1, assayed as its arylesterase activity, and SAA were measured together with plasma lipids and lipoproteins, high-sensitive C-reactive protein (hs-CRP) and insulin resistance (homeostasis model assessment (HOMA(ir)). RESULTS: PON-1 activity was decreased (p=0.023), whereas SAA levels were increased (p=0.042) in MetS subjects, coinciding with higher hs-CRP levels and HOMA(ir) values. Multiple linear regression analysis revealed that age- and gender-adjusted PON-1 activity was related inversely to SAA (β=-0.256, p=0.020) after adjustment for MetS, or alternatively for hs-CRP and HOMA(ir) (β=-0.271, p=0.049). CONCLUSIONS: Decreased serum PON-1 activity in MetS may in part be attributable to higher SAA levels. We suggest that higher SAA levels contribute to impaired HDL anti-oxidative function in MetS via an effect on PON-1 regulation. SN - 1873-5487 UR - https://www.unboundmedicine.com/medline/citation/21722818/Lower_serum_paraoxonase_1_activity_is_related_to_higher_serum_amyloid_a_levels_in_metabolic_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0188-4409(11)00087-7 DB - PRIME DP - Unbound Medicine ER -