Tags

Type your tag names separated by a space and hit enter

Prevalence and characteristics of restless legs syndrome (RLS) in the elderly and the relation of serum ferritin levels with disease severity: hospital-based study from Istanbul, Turkey.
Arch Gerontol Geriatr 2012 Jul-Aug; 55(1):73-6AG

Abstract

The RLS is an underdiagnosed condition, characterized by unpleasant sensations in the legs. Pathophysiological mechanisms may include iron deficiency as reflected by low serum ferritin levels and dopaminergic system dysfunction. The purpose of our study was to investigate the prevalence and characteristics of RLS in the elderly and the relation of serum ferritin levels with disease severity. Ambulatory 1012 (621 women, 391 men, mean age: 73.51 ± 7.12 years) consecutive patients above 65 years who admitted to our clinic for any reason were evaluated according to the International RLS Study Group (IRLSSG) criteria: 103 patients (74 women, 29 men, mean age: 72.43 ± 6.31) (10.18%) had RLS diagnosis. Only 9 of them had known RLS. The duration of symptoms was 4.80 ± 4.65 years and 27 patients (26.2%) had positive family history. The average of serum ferritin levels was 39.13 ± 23.74 ng/ml and 71 patients (68.9%) had serum ferritin levels ≤ 50 ng/ml. The disease severity was evaluated with IRLSSG rating scale. Patients were classified as severe-very severe group (n=49) and mild-moderate group (n=54). The ferritin levels of severe-very severe disease group were lower than those of mild-moderate disease group (26.01 ± 15.82 ng/ml versus 49.87 ± 23.24 ng/ml, p<0.001). Our data show that RLS is very common in the elderly and the disease is more severe in patients with lower ferritin levels.

Authors+Show Affiliations

Department of Internal Medicine, Istanbul University, Cerrahpasa Medical Faculty, Koca Mustafa Pasa Street, Fatih, Istanbul 34098, Turkey. acurgunlu@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21722973

Citation

Çurgunlu, Asli, et al. "Prevalence and Characteristics of Restless Legs Syndrome (RLS) in the Elderly and the Relation of Serum Ferritin Levels With Disease Severity: Hospital-based Study From Istanbul, Turkey." Archives of Gerontology and Geriatrics, vol. 55, no. 1, 2012, pp. 73-6.
Çurgunlu A, Döventaş A, Karadeniz D, et al. Prevalence and characteristics of restless legs syndrome (RLS) in the elderly and the relation of serum ferritin levels with disease severity: hospital-based study from Istanbul, Turkey. Arch Gerontol Geriatr. 2012;55(1):73-6.
Çurgunlu, A., Döventaş, A., Karadeniz, D., Erdinçler, D. S., Oztürk, A. K., Karter, Y., ... Beğer, T. (2012). Prevalence and characteristics of restless legs syndrome (RLS) in the elderly and the relation of serum ferritin levels with disease severity: hospital-based study from Istanbul, Turkey. Archives of Gerontology and Geriatrics, 55(1), pp. 73-6. doi:10.1016/j.archger.2011.06.002.
Çurgunlu A, et al. Prevalence and Characteristics of Restless Legs Syndrome (RLS) in the Elderly and the Relation of Serum Ferritin Levels With Disease Severity: Hospital-based Study From Istanbul, Turkey. Arch Gerontol Geriatr. 2012;55(1):73-6. PubMed PMID: 21722973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and characteristics of restless legs syndrome (RLS) in the elderly and the relation of serum ferritin levels with disease severity: hospital-based study from Istanbul, Turkey. AU - Çurgunlu,Asli, AU - Döventaş,Alper, AU - Karadeniz,Derya, AU - Erdinçler,Deniz Suna, AU - Oztürk,Ayşe Kutlu, AU - Karter,Yesari, AU - Yaldiran,Adnan, AU - Sipahioğlu,Fikret, AU - Beğer,Tanju, Y1 - 2011/06/30/ PY - 2010/12/27/received PY - 2011/05/29/revised PY - 2011/05/31/accepted PY - 2011/7/5/entrez PY - 2011/7/5/pubmed PY - 2012/9/28/medline SP - 73 EP - 6 JF - Archives of gerontology and geriatrics JO - Arch Gerontol Geriatr VL - 55 IS - 1 N2 - The RLS is an underdiagnosed condition, characterized by unpleasant sensations in the legs. Pathophysiological mechanisms may include iron deficiency as reflected by low serum ferritin levels and dopaminergic system dysfunction. The purpose of our study was to investigate the prevalence and characteristics of RLS in the elderly and the relation of serum ferritin levels with disease severity. Ambulatory 1012 (621 women, 391 men, mean age: 73.51 ± 7.12 years) consecutive patients above 65 years who admitted to our clinic for any reason were evaluated according to the International RLS Study Group (IRLSSG) criteria: 103 patients (74 women, 29 men, mean age: 72.43 ± 6.31) (10.18%) had RLS diagnosis. Only 9 of them had known RLS. The duration of symptoms was 4.80 ± 4.65 years and 27 patients (26.2%) had positive family history. The average of serum ferritin levels was 39.13 ± 23.74 ng/ml and 71 patients (68.9%) had serum ferritin levels ≤ 50 ng/ml. The disease severity was evaluated with IRLSSG rating scale. Patients were classified as severe-very severe group (n=49) and mild-moderate group (n=54). The ferritin levels of severe-very severe disease group were lower than those of mild-moderate disease group (26.01 ± 15.82 ng/ml versus 49.87 ± 23.24 ng/ml, p<0.001). Our data show that RLS is very common in the elderly and the disease is more severe in patients with lower ferritin levels. SN - 1872-6976 UR - https://www.unboundmedicine.com/medline/citation/21722973/Prevalence_and_characteristics_of_restless_legs_syndrome__RLS__in_the_elderly_and_the_relation_of_serum_ferritin_levels_with_disease_severity:_hospital_based_study_from_Istanbul_Turkey_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-4943(11)00153-1 DB - PRIME DP - Unbound Medicine ER -