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Effectiveness of the monovalent influenza A(H1N1)2009 vaccine in Navarre, Spain, 2009-2010: cohort and case-control study.
Vaccine 2011; 29(35):5919-24V

Abstract

We defined a population-based cohort (596,755 subjects) in Navarre, Spain, using electronic records from physicians, to evaluate the effectiveness of the monovalent A(H1N1)2009 vaccine in preventing influenza in the 2009-2010 pandemic season. During the 9-week period of vaccine availability and circulation of the A(H1N1)2009 virus, 4608 cases of medically attended influenza-like illness (MA-ILI) were registered (46 per 1000 person-years). After adjustment for sociodemographic covariables, outpatient visits and major chronic conditions, vaccination was associated with a 32% (95% CI: 8-50%) reduction in the overall incidence of MA-ILI. In a test negative case-control analysis nested in the cohort, swabs from 633 patients were included, and 123 were confirmed for A(H1N1)2009 influenza. No confirmed case had received A(H1N1)2009 vaccine versus 9.6% of controls (p<0.001). The vaccine effectiveness in preventing laboratory-confirmed influenza was 89% (95% CI: 36-100%) after adjusting for age, health care setting, major chronic conditions and period. Pandemic vaccine was effective in preventing MA-ILI and confirmed cases of influenza A(H1N1)2009 in the 2009-2010 season.

Authors+Show Affiliations

Instituto de Salud Pública de Navarra, Pamplona, Spain. jcastilc@navarra.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21723358

Citation

Castilla, Jesús, et al. "Effectiveness of the Monovalent Influenza A(H1N1)2009 Vaccine in Navarre, Spain, 2009-2010: Cohort and Case-control Study." Vaccine, vol. 29, no. 35, 2011, pp. 5919-24.
Castilla J, Morán J, Martínez-Artola V, et al. Effectiveness of the monovalent influenza A(H1N1)2009 vaccine in Navarre, Spain, 2009-2010: cohort and case-control study. Vaccine. 2011;29(35):5919-24.
Castilla, J., Morán, J., Martínez-Artola, V., Fernández-Alonso, M., Guevara, M., Cenoz, M. G., ... Barricarte, A. (2011). Effectiveness of the monovalent influenza A(H1N1)2009 vaccine in Navarre, Spain, 2009-2010: cohort and case-control study. Vaccine, 29(35), pp. 5919-24. doi:10.1016/j.vaccine.2011.06.063.
Castilla J, et al. Effectiveness of the Monovalent Influenza A(H1N1)2009 Vaccine in Navarre, Spain, 2009-2010: Cohort and Case-control Study. Vaccine. 2011 Aug 11;29(35):5919-24. PubMed PMID: 21723358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of the monovalent influenza A(H1N1)2009 vaccine in Navarre, Spain, 2009-2010: cohort and case-control study. AU - Castilla,Jesús, AU - Morán,Julio, AU - Martínez-Artola,Víctor, AU - Fernández-Alonso,Mirian, AU - Guevara,Marcela, AU - Cenoz,Manuel García, AU - Reina,Gabriel, AU - Alvarez,Nerea, AU - Arriazu,Maite, AU - Elía,Fernando, AU - Salcedo,Esther, AU - Barricarte,Aurelio, AU - ,, Y1 - 2011/06/30/ PY - 2011/03/03/received PY - 2011/06/10/revised PY - 2011/06/15/accepted PY - 2011/7/5/entrez PY - 2011/7/5/pubmed PY - 2011/12/14/medline SP - 5919 EP - 24 JF - Vaccine JO - Vaccine VL - 29 IS - 35 N2 - We defined a population-based cohort (596,755 subjects) in Navarre, Spain, using electronic records from physicians, to evaluate the effectiveness of the monovalent A(H1N1)2009 vaccine in preventing influenza in the 2009-2010 pandemic season. During the 9-week period of vaccine availability and circulation of the A(H1N1)2009 virus, 4608 cases of medically attended influenza-like illness (MA-ILI) were registered (46 per 1000 person-years). After adjustment for sociodemographic covariables, outpatient visits and major chronic conditions, vaccination was associated with a 32% (95% CI: 8-50%) reduction in the overall incidence of MA-ILI. In a test negative case-control analysis nested in the cohort, swabs from 633 patients were included, and 123 were confirmed for A(H1N1)2009 influenza. No confirmed case had received A(H1N1)2009 vaccine versus 9.6% of controls (p<0.001). The vaccine effectiveness in preventing laboratory-confirmed influenza was 89% (95% CI: 36-100%) after adjusting for age, health care setting, major chronic conditions and period. Pandemic vaccine was effective in preventing MA-ILI and confirmed cases of influenza A(H1N1)2009 in the 2009-2010 season. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21723358/Effectiveness_of_the_monovalent_influenza_A_H1N1_2009_vaccine_in_Navarre_Spain_2009_2010:_cohort_and_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(11)00927-3 DB - PRIME DP - Unbound Medicine ER -