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Effectiveness of the monovalent influenza A(H1N1)2009 vaccine in Navarre, Spain, 2009-2010: cohort and case-control study.
Vaccine. 2011 Aug 11; 29(35):5919-24.V

Abstract

We defined a population-based cohort (596,755 subjects) in Navarre, Spain, using electronic records from physicians, to evaluate the effectiveness of the monovalent A(H1N1)2009 vaccine in preventing influenza in the 2009-2010 pandemic season. During the 9-week period of vaccine availability and circulation of the A(H1N1)2009 virus, 4608 cases of medically attended influenza-like illness (MA-ILI) were registered (46 per 1000 person-years). After adjustment for sociodemographic covariables, outpatient visits and major chronic conditions, vaccination was associated with a 32% (95% CI: 8-50%) reduction in the overall incidence of MA-ILI. In a test negative case-control analysis nested in the cohort, swabs from 633 patients were included, and 123 were confirmed for A(H1N1)2009 influenza. No confirmed case had received A(H1N1)2009 vaccine versus 9.6% of controls (p<0.001). The vaccine effectiveness in preventing laboratory-confirmed influenza was 89% (95% CI: 36-100%) after adjusting for age, health care setting, major chronic conditions and period. Pandemic vaccine was effective in preventing MA-ILI and confirmed cases of influenza A(H1N1)2009 in the 2009-2010 season.

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Authors+Show Affiliations

Castilla J
Instituto de Salud Pública de Navarra, Pamplona, Spain. jcastilc@navarra.es
Morán J
No affiliation info available
Martínez-Artola V
No affiliation info available
Fernández-Alonso M
No affiliation info available
Guevara M
No affiliation info available
Cenoz MG
No affiliation info available
Reina G
No affiliation info available
Alvarez N
No affiliation info available
Arriazu M
No affiliation info available
Elía F
No affiliation info available
Salcedo E
No affiliation info available
Barricarte A
No affiliation info available
Primary Health Care Sentinel Network of Navarre
No affiliation info available

MeSH

AdolescentAdultAgedAged, 80 and overCase-Control StudiesChildChild, PreschoolCohort StudiesFemaleHumansIncidenceInfantInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesInfluenza, HumanMaleMiddle AgedPandemicsProspective StudiesSeasonsSpainTreatment OutcomeVaccinationYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21723358

Citation

Castilla, Jesús, et al. "Effectiveness of the Monovalent Influenza A(H1N1)2009 Vaccine in Navarre, Spain, 2009-2010: Cohort and Case-control Study." Vaccine, vol. 29, no. 35, 2011, pp. 5919-24.
Castilla J, Morán J, Martínez-Artola V, et al. Effectiveness of the monovalent influenza A(H1N1)2009 vaccine in Navarre, Spain, 2009-2010: cohort and case-control study. Vaccine. 2011;29(35):5919-24.
Castilla, J., Morán, J., Martínez-Artola, V., Fernández-Alonso, M., Guevara, M., Cenoz, M. G., Reina, G., Alvarez, N., Arriazu, M., Elía, F., Salcedo, E., & Barricarte, A. (2011). Effectiveness of the monovalent influenza A(H1N1)2009 vaccine in Navarre, Spain, 2009-2010: cohort and case-control study. Vaccine, 29(35), 5919-24. https://doi.org/10.1016/j.vaccine.2011.06.063
Castilla J, et al. Effectiveness of the Monovalent Influenza A(H1N1)2009 Vaccine in Navarre, Spain, 2009-2010: Cohort and Case-control Study. Vaccine. 2011 Aug 11;29(35):5919-24. PubMed PMID: 21723358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of the monovalent influenza A(H1N1)2009 vaccine in Navarre, Spain, 2009-2010: cohort and case-control study. AU - Castilla,Jesús, AU - Morán,Julio, AU - Martínez-Artola,Víctor, AU - Fernández-Alonso,Mirian, AU - Guevara,Marcela, AU - Cenoz,Manuel García, AU - Reina,Gabriel, AU - Alvarez,Nerea, AU - Arriazu,Maite, AU - Elía,Fernando, AU - Salcedo,Esther, AU - Barricarte,Aurelio, AU - ,, Y1 - 2011/06/30/ PY - 2011/03/03/received PY - 2011/06/10/revised PY - 2011/06/15/accepted PY - 2011/7/5/entrez PY - 2011/7/5/pubmed PY - 2011/12/14/medline SP - 5919 EP - 24 JF - Vaccine JO - Vaccine VL - 29 IS - 35 N2 - We defined a population-based cohort (596,755 subjects) in Navarre, Spain, using electronic records from physicians, to evaluate the effectiveness of the monovalent A(H1N1)2009 vaccine in preventing influenza in the 2009-2010 pandemic season. During the 9-week period of vaccine availability and circulation of the A(H1N1)2009 virus, 4608 cases of medically attended influenza-like illness (MA-ILI) were registered (46 per 1000 person-years). After adjustment for sociodemographic covariables, outpatient visits and major chronic conditions, vaccination was associated with a 32% (95% CI: 8-50%) reduction in the overall incidence of MA-ILI. In a test negative case-control analysis nested in the cohort, swabs from 633 patients were included, and 123 were confirmed for A(H1N1)2009 influenza. No confirmed case had received A(H1N1)2009 vaccine versus 9.6% of controls (p<0.001). The vaccine effectiveness in preventing laboratory-confirmed influenza was 89% (95% CI: 36-100%) after adjusting for age, health care setting, major chronic conditions and period. Pandemic vaccine was effective in preventing MA-ILI and confirmed cases of influenza A(H1N1)2009 in the 2009-2010 season. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21723358/Effectiveness_of_the_monovalent_influenza_A_H1N1_2009_vaccine_in_Navarre_Spain_2009_2010:_cohort_and_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(11)00927-3 DB - PRIME DP - Unbound Medicine ER -