Tags

Type your tag names separated by a space and hit enter

Protective effects of pentoxifylline and nimodipine on acoustic trauma in Guinea pig cochlea.
Otol Neurotol. 2011 Aug; 32(6):919-25.ON

Abstract

OBJECTIVE

To examine the protective effects of the vasodilator and hemorheologically active drug pentoxifylline and the calcium channel blocker nimodipine on the cochlea after acoustic overexposure in guinea pigs.

METHODS

Eighteen guinea pigs were used. The animals were divided into 5 groups: 1) control, 2) acoustic trauma, 3) nimodipine plus acoustic trauma, 4) pentoxifylline plus acoustic trauma, and 5) pentoxifylline plus nimodipine plus acoustic trauma. Nimodipine was given to the guinea pigs 3 mg/kg intraperitoneally in a single dose; pentoxifylline was given 150 mg/kg in a single dose intraperitoneally. A gunnery range was used to create acoustic trauma. The auditory brainstem response of each guinea pig was determined first; then, the animals were killed, and their cochleas were examined under an electron microscope.

RESULTS

In the acoustic trauma group, negative auditory brainstem response potentials were seen as was well-adjusted cellular damage to the organ of Corti. In the pentoxifylline group, near-normal auditory brainstem response recordings and organ of Corti histologic findings were found. Organ of Corti damage was seen in the pentoxifylline plus nimodipine plus acoustic trauma group.

CONCLUSION

We determined that pentoxifylline was highly protective against noise, but nimodipine was not. Also, pentoxifylline and nimodipine, when used together, increased damage to the organ of Corti.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, Baskent University, Ankara, Turkey. leylakansu@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21725258

Citation

Kansu, Leyla, et al. "Protective Effects of Pentoxifylline and Nimodipine On Acoustic Trauma in Guinea Pig Cochlea." Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, vol. 32, no. 6, 2011, pp. 919-25.
Kansu L, Ozkarakas H, Efendi H, et al. Protective effects of pentoxifylline and nimodipine on acoustic trauma in Guinea pig cochlea. Otol Neurotol. 2011;32(6):919-25.
Kansu, L., Ozkarakas, H., Efendi, H., & Okar, I. (2011). Protective effects of pentoxifylline and nimodipine on acoustic trauma in Guinea pig cochlea. Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 32(6), 919-25. https://doi.org/10.1097/MAO.0b013e3182267e06
Kansu L, et al. Protective Effects of Pentoxifylline and Nimodipine On Acoustic Trauma in Guinea Pig Cochlea. Otol Neurotol. 2011;32(6):919-25. PubMed PMID: 21725258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of pentoxifylline and nimodipine on acoustic trauma in Guinea pig cochlea. AU - Kansu,Leyla, AU - Ozkarakas,Haluk, AU - Efendi,Husnu, AU - Okar,Imer, PY - 2011/7/5/entrez PY - 2011/7/5/pubmed PY - 2011/12/14/medline SP - 919 EP - 25 JF - Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology JO - Otol. Neurotol. VL - 32 IS - 6 N2 - OBJECTIVE: To examine the protective effects of the vasodilator and hemorheologically active drug pentoxifylline and the calcium channel blocker nimodipine on the cochlea after acoustic overexposure in guinea pigs. METHODS: Eighteen guinea pigs were used. The animals were divided into 5 groups: 1) control, 2) acoustic trauma, 3) nimodipine plus acoustic trauma, 4) pentoxifylline plus acoustic trauma, and 5) pentoxifylline plus nimodipine plus acoustic trauma. Nimodipine was given to the guinea pigs 3 mg/kg intraperitoneally in a single dose; pentoxifylline was given 150 mg/kg in a single dose intraperitoneally. A gunnery range was used to create acoustic trauma. The auditory brainstem response of each guinea pig was determined first; then, the animals were killed, and their cochleas were examined under an electron microscope. RESULTS: In the acoustic trauma group, negative auditory brainstem response potentials were seen as was well-adjusted cellular damage to the organ of Corti. In the pentoxifylline group, near-normal auditory brainstem response recordings and organ of Corti histologic findings were found. Organ of Corti damage was seen in the pentoxifylline plus nimodipine plus acoustic trauma group. CONCLUSION: We determined that pentoxifylline was highly protective against noise, but nimodipine was not. Also, pentoxifylline and nimodipine, when used together, increased damage to the organ of Corti. SN - 1537-4505 UR - https://www.unboundmedicine.com/medline/citation/21725258/Protective_effects_of_pentoxifylline_and_nimodipine_on_acoustic_trauma_in_Guinea_pig_cochlea_ L2 - http://dx.doi.org/10.1097/MAO.0b013e3182267e06 DB - PRIME DP - Unbound Medicine ER -