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Rhododendrin, an analgesic/anti-inflammatory arylbutanoid glycoside, from the leaves of Rhododendron aureum.
Arch Pharm Res. 2011 Jun; 34(6):971-8.AP

Abstract

To identify an analgesic/anti-inflammatory component from the leaves of Rhododendron aureum (Ericaceae), phytochemical isolation and pharmacological assays (writhing assays and vascular permeability assay for analgesic action in mice; carrageenan-induced paw edemaand TPA-induced ear edema assays of anti-inflammatory action in rats) were performed. Four compounds were isolated from the active fraction (BuOH fraction) by silica gel column chromatography and identified as (-)-rhododendrol, (-)-rhododendrin, avicularin and hyperoside by spectroscopic methods. Rhododendrin, the main compound of the BuOH fraction, exhibited significant analgesic actions in mice and anti-inflammatory actions in rats. This compound accounted for 3.1% of the MeOH extract and 0.48% of dried leaves, respectively, on HPLC analysis. These results suggest that rhododendrin is the major biologically active substance in the leaves of R. aureum with analgesic/anti-inflammatory activity.

Authors+Show Affiliations

Department of Pharmaceutical Engineering, Sangji University, Wonju 220-702, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21725818

Citation

Kim, Myung-Hoe, et al. "Rhododendrin, an Analgesic/anti-inflammatory Arylbutanoid Glycoside, From the Leaves of Rhododendron Aureum." Archives of Pharmacal Research, vol. 34, no. 6, 2011, pp. 971-8.
Kim MH, Nugroho A, Choi J, et al. Rhododendrin, an analgesic/anti-inflammatory arylbutanoid glycoside, from the leaves of Rhododendron aureum. Arch Pharm Res. 2011;34(6):971-8.
Kim, M. H., Nugroho, A., Choi, J., Park, J. H., & Park, H. J. (2011). Rhododendrin, an analgesic/anti-inflammatory arylbutanoid glycoside, from the leaves of Rhododendron aureum. Archives of Pharmacal Research, 34(6), 971-8. https://doi.org/10.1007/s12272-011-0614-1
Kim MH, et al. Rhododendrin, an Analgesic/anti-inflammatory Arylbutanoid Glycoside, From the Leaves of Rhododendron Aureum. Arch Pharm Res. 2011;34(6):971-8. PubMed PMID: 21725818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rhododendrin, an analgesic/anti-inflammatory arylbutanoid glycoside, from the leaves of Rhododendron aureum. AU - Kim,Myung-Hoe, AU - Nugroho,Agung, AU - Choi,Jongwon, AU - Park,Jong Hee, AU - Park,Hee-Juhn, Y1 - 2011/07/02/ PY - 2010/10/14/received PY - 2011/01/11/accepted PY - 2010/12/26/revised PY - 2011/7/5/entrez PY - 2011/7/5/pubmed PY - 2011/11/1/medline SP - 971 EP - 8 JF - Archives of pharmacal research JO - Arch. Pharm. Res. VL - 34 IS - 6 N2 - To identify an analgesic/anti-inflammatory component from the leaves of Rhododendron aureum (Ericaceae), phytochemical isolation and pharmacological assays (writhing assays and vascular permeability assay for analgesic action in mice; carrageenan-induced paw edemaand TPA-induced ear edema assays of anti-inflammatory action in rats) were performed. Four compounds were isolated from the active fraction (BuOH fraction) by silica gel column chromatography and identified as (-)-rhododendrol, (-)-rhododendrin, avicularin and hyperoside by spectroscopic methods. Rhododendrin, the main compound of the BuOH fraction, exhibited significant analgesic actions in mice and anti-inflammatory actions in rats. This compound accounted for 3.1% of the MeOH extract and 0.48% of dried leaves, respectively, on HPLC analysis. These results suggest that rhododendrin is the major biologically active substance in the leaves of R. aureum with analgesic/anti-inflammatory activity. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/21725818/Rhododendrin_an_analgesic/anti_inflammatory_arylbutanoid_glycoside_from_the_leaves_of_Rhododendron_aureum_ L2 - https://dx.doi.org/10.1007/s12272-011-0614-1 DB - PRIME DP - Unbound Medicine ER -