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The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder.
World J Biol Psychiatry 2012; 13(4):306-11WJ

Abstract

OBJECTIVES

Psychotic symptoms frequently occur in veterans with combat-related posttraumatic stress disorder (PTSD). Brain-derived neurotrophic factor (BDNF) plays a major role in neurodevelopment, neuro-regeneration, neurotransmission, learning, regulation of mood and stress responses. The Met allele of the functional polymorphism, BDNF Val66Met, is associated with psychotic disorders. This study intended to assess whether the Met allele is overrepresented in unrelated Caucasian male veterans with psychotic PTSD compared to veteran controls.

METHODS

The BDNF Val66Met variants were genotyped in 576 veterans: 206 veterans without PTSD and 370 veterans with PTSD subdivided into groups with or without psychotic features.

RESULTS

Veterans with psychotic PTSD were more frequently carriers of one or two Met alleles of the BDNF Val66Met polymorphism than veterans with PTSD without psychotic features and veterans without PTSD.

CONCLUSIONS

The study shows that veterans with psychotic PTSD carried more Met alleles of the BDNF Val66Met than non-psychotic veterans with PTSD or veterans without PTSD. The results might add further support to the hypothesis that psychotic PTSD is a more severe subtype of PTSD.

Authors+Show Affiliations

Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia. npivac@irb.hrNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21728904

Citation

Pivac, Nela, et al. "The Association Between Brain-derived Neurotrophic Factor Val66Met Variants and Psychotic Symptoms in Posttraumatic Stress Disorder." The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry, vol. 13, no. 4, 2012, pp. 306-11.
Pivac N, Kozaric-Kovacic D, Grubisic-Ilic M, et al. The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder. World J Biol Psychiatry. 2012;13(4):306-11.
Pivac, N., Kozaric-Kovacic, D., Grubisic-Ilic, M., Nedic, G., Rakos, I., Nikolac, M., ... Muck-Seler, D. (2012). The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry, 13(4), pp. 306-11. doi:10.3109/15622975.2011.582883.
Pivac N, et al. The Association Between Brain-derived Neurotrophic Factor Val66Met Variants and Psychotic Symptoms in Posttraumatic Stress Disorder. World J Biol Psychiatry. 2012;13(4):306-11. PubMed PMID: 21728904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder. AU - Pivac,Nela, AU - Kozaric-Kovacic,Dragica, AU - Grubisic-Ilic,Mirjana, AU - Nedic,Gordana, AU - Rakos,Iva, AU - Nikolac,Matea, AU - Blazev,Martina, AU - Muck-Seler,Dorotea, Y1 - 2011/07/06/ PY - 2011/7/7/entrez PY - 2011/7/7/pubmed PY - 2012/9/18/medline SP - 306 EP - 11 JF - The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry JO - World J. Biol. Psychiatry VL - 13 IS - 4 N2 - OBJECTIVES: Psychotic symptoms frequently occur in veterans with combat-related posttraumatic stress disorder (PTSD). Brain-derived neurotrophic factor (BDNF) plays a major role in neurodevelopment, neuro-regeneration, neurotransmission, learning, regulation of mood and stress responses. The Met allele of the functional polymorphism, BDNF Val66Met, is associated with psychotic disorders. This study intended to assess whether the Met allele is overrepresented in unrelated Caucasian male veterans with psychotic PTSD compared to veteran controls. METHODS: The BDNF Val66Met variants were genotyped in 576 veterans: 206 veterans without PTSD and 370 veterans with PTSD subdivided into groups with or without psychotic features. RESULTS: Veterans with psychotic PTSD were more frequently carriers of one or two Met alleles of the BDNF Val66Met polymorphism than veterans with PTSD without psychotic features and veterans without PTSD. CONCLUSIONS: The study shows that veterans with psychotic PTSD carried more Met alleles of the BDNF Val66Met than non-psychotic veterans with PTSD or veterans without PTSD. The results might add further support to the hypothesis that psychotic PTSD is a more severe subtype of PTSD. SN - 1814-1412 UR - https://www.unboundmedicine.com/medline/citation/21728904/The_association_between_brain_derived_neurotrophic_factor_Val66Met_variants_and_psychotic_symptoms_in_posttraumatic_stress_disorder_ L2 - http://www.tandfonline.com/doi/full/10.3109/15622975.2011.582883 DB - PRIME DP - Unbound Medicine ER -