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Stress and consumption of alcohol in humans with a Type 1 family history of alcoholism in an experimental laboratory setting.
Pharmacol Biochem Behav. 2011 Oct; 99(4):696-703.PB

Abstract

BACKGROUND

This paper investigates how stress interacts with alcohol consumption in subjects with a family history of alcoholism. One mechanism for increases in alcohol intake may be that stress alters the subjective effects produced by the drug.

METHODS

58 healthy volunteers, divided into two groups of family history positive (FHP) and two groups of family history negative (FHN) participated in two laboratory sessions, in which they performed in one out of two sessions a stress task. Then subjects were allowed to choose up to six additional drinks of ethanol or placebo depending on which session they were randomly assigned to start with.

RESULTS

It was found that FHP subjects increased their consumption of alcohol after stress.

CONCLUSIONS

It is possible that both stress and alcohol specifically exaggerate the feelings of the reward in the FHP individuals in such way that it may increase the likelihood of consuming more alcohol.

Authors+Show Affiliations

Institute of Neuroscience and Physiology, Section of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Blå Stråket 15, SE-41345 Gothenburg, Sweden. anna.soderpalm@neuro.gu.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21729717

Citation

Gordh, Anna H V Söderpalm, et al. "Stress and Consumption of Alcohol in Humans With a Type 1 Family History of Alcoholism in an Experimental Laboratory Setting." Pharmacology, Biochemistry, and Behavior, vol. 99, no. 4, 2011, pp. 696-703.
Gordh AH, Brkic S, Söderpalm B. Stress and consumption of alcohol in humans with a Type 1 family history of alcoholism in an experimental laboratory setting. Pharmacol Biochem Behav. 2011;99(4):696-703.
Gordh, A. H., Brkic, S., & Söderpalm, B. (2011). Stress and consumption of alcohol in humans with a Type 1 family history of alcoholism in an experimental laboratory setting. Pharmacology, Biochemistry, and Behavior, 99(4), 696-703. https://doi.org/10.1016/j.pbb.2011.05.028
Gordh AH, Brkic S, Söderpalm B. Stress and Consumption of Alcohol in Humans With a Type 1 Family History of Alcoholism in an Experimental Laboratory Setting. Pharmacol Biochem Behav. 2011;99(4):696-703. PubMed PMID: 21729717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stress and consumption of alcohol in humans with a Type 1 family history of alcoholism in an experimental laboratory setting. AU - Gordh,Anna H V Söderpalm, AU - Brkic,Sejla, AU - Söderpalm,Bo, Y1 - 2011/06/26/ PY - 2010/12/10/received PY - 2011/05/18/revised PY - 2011/05/26/accepted PY - 2011/7/7/entrez PY - 2011/7/7/pubmed PY - 2011/12/14/medline SP - 696 EP - 703 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 99 IS - 4 N2 - BACKGROUND: This paper investigates how stress interacts with alcohol consumption in subjects with a family history of alcoholism. One mechanism for increases in alcohol intake may be that stress alters the subjective effects produced by the drug. METHODS: 58 healthy volunteers, divided into two groups of family history positive (FHP) and two groups of family history negative (FHN) participated in two laboratory sessions, in which they performed in one out of two sessions a stress task. Then subjects were allowed to choose up to six additional drinks of ethanol or placebo depending on which session they were randomly assigned to start with. RESULTS: It was found that FHP subjects increased their consumption of alcohol after stress. CONCLUSIONS: It is possible that both stress and alcohol specifically exaggerate the feelings of the reward in the FHP individuals in such way that it may increase the likelihood of consuming more alcohol. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/21729717/Stress_and_consumption_of_alcohol_in_humans_with_a_Type_1_family_history_of_alcoholism_in_an_experimental_laboratory_setting_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(11)00188-2 DB - PRIME DP - Unbound Medicine ER -