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Sevoflurane as a potential replacement for halothane in diagnostic testing for malignant hyperthermia susceptibility: results of a preliminary study.
Minerva Anestesiol. 2011 Aug; 77(8):768-73.MA

Abstract

BACKGROUND

To diagnose malignant hyperthermia (MH) susceptibility, muscle bundles are exposed to halothane and caffeine. We investigated whether sevoflurane, which is more clinically relevant but less potent of an anesthetic, could replace halothane in diagnostic MH testing.

METHODS

With prior written consent, muscle bundles from 6 malignant hyperthermia susceptible (MHS) and 5 non-susceptible (MHN) individuals were exposed to increasing concentrations of sevoflurane (1.3; 2.6; 5.2 vol%). In addition, muscles from 9 MHS and 8 MHN were tested with a rapid exposure to 8 vol% of sevoflurane. Maximal contractures were measured and statistically analyzed (Mann-Whitney-U-test; P<0.05).

RESULTS

There were no differences in weight, length or pre-drug tension of the muscle bundles. Incremental sevoflurane concentrations induced no differences in contracture between susceptible and non-susceptible muscles. The rapid application of sevoflurane induced significant contractures in all malignant hyperthermia susceptible compared with non-susceptible individuals.

CONCLUSION

The rapid application of a high sevoflurane concentration but not an increasing stepwise application allowed for the diagnostic discrimination of susceptible individuals.

Authors+Show Affiliations

Department of Anesthesiology, University Hospital Würzburg, Würzburg, Germany. tom.metterlein@gmx.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21730923

Citation

Metterlein, T, et al. "Sevoflurane as a Potential Replacement for Halothane in Diagnostic Testing for Malignant Hyperthermia Susceptibility: Results of a Preliminary Study." Minerva Anestesiologica, vol. 77, no. 8, 2011, pp. 768-73.
Metterlein T, Hartung E, Schuster F, et al. Sevoflurane as a potential replacement for halothane in diagnostic testing for malignant hyperthermia susceptibility: results of a preliminary study. Minerva Anestesiol. 2011;77(8):768-73.
Metterlein, T., Hartung, E., Schuster, F., Roewer, N., & Anetseder, M. (2011). Sevoflurane as a potential replacement for halothane in diagnostic testing for malignant hyperthermia susceptibility: results of a preliminary study. Minerva Anestesiologica, 77(8), 768-73.
Metterlein T, et al. Sevoflurane as a Potential Replacement for Halothane in Diagnostic Testing for Malignant Hyperthermia Susceptibility: Results of a Preliminary Study. Minerva Anestesiol. 2011;77(8):768-73. PubMed PMID: 21730923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sevoflurane as a potential replacement for halothane in diagnostic testing for malignant hyperthermia susceptibility: results of a preliminary study. AU - Metterlein,T, AU - Hartung,E, AU - Schuster,F, AU - Roewer,N, AU - Anetseder,M, PY - 2011/7/7/entrez PY - 2011/7/7/pubmed PY - 2011/11/4/medline SP - 768 EP - 73 JF - Minerva anestesiologica JO - Minerva Anestesiol VL - 77 IS - 8 N2 - BACKGROUND: To diagnose malignant hyperthermia (MH) susceptibility, muscle bundles are exposed to halothane and caffeine. We investigated whether sevoflurane, which is more clinically relevant but less potent of an anesthetic, could replace halothane in diagnostic MH testing. METHODS: With prior written consent, muscle bundles from 6 malignant hyperthermia susceptible (MHS) and 5 non-susceptible (MHN) individuals were exposed to increasing concentrations of sevoflurane (1.3; 2.6; 5.2 vol%). In addition, muscles from 9 MHS and 8 MHN were tested with a rapid exposure to 8 vol% of sevoflurane. Maximal contractures were measured and statistically analyzed (Mann-Whitney-U-test; P<0.05). RESULTS: There were no differences in weight, length or pre-drug tension of the muscle bundles. Incremental sevoflurane concentrations induced no differences in contracture between susceptible and non-susceptible muscles. The rapid application of sevoflurane induced significant contractures in all malignant hyperthermia susceptible compared with non-susceptible individuals. CONCLUSION: The rapid application of a high sevoflurane concentration but not an increasing stepwise application allowed for the diagnostic discrimination of susceptible individuals. SN - 1827-1596 UR - https://www.unboundmedicine.com/medline/citation/21730923/Sevoflurane_as_a_potential_replacement_for_halothane_in_diagnostic_testing_for_malignant_hyperthermia_susceptibility:_results_of_a_preliminary_study_ L2 - http://www.minervamedica.it/index2.t?show=R02Y2011N08A0768 DB - PRIME DP - Unbound Medicine ER -