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Cryptococcus gattii chorioretinitis in a ferret.
Vet Ophthalmol. 2011 Jul; 14(4):262-6.VO

Abstract

Bilateral exudative chorioretinitis was diagnosed in an 18-month-old male neutered ferret (Mustela putorius furo) with a generalized Cryptococcus gattii infection confirmed by PCR. The animal was referred to the Ophthalmology Service of the Autonomous University of Barcelona (VTH-UAB) for acute onset blindness. Complete ophthalmic examination revealed absent menace response and dazzle reflex in both eyes (OU), as well as subretinal edema located in the tapetal fundus. At that time, the clinical ophthalmologic diagnosis was bilateral exudative chorioretinitis. Treatment with prednisone (0.5 mg/kg PO q24 h) was instituted in addition to the ongoing treatment with fluconazole (10 mg/kg PO q24 h). The following rechecks revealed secondary cataracts with subsequent lens subluxation and panretinal degeneration OU. Despite being blind and the poor prognosis of disseminate cryptococcosis, the patient remained active and in good body condition during 6 months after the initial diagnosis. At that time, the ferret showed ataxia, incontinence, and generalized pain. A magnetic resonance imaging study revealed a mass affecting the spine. The owners declined further investigations and the ferret was humanely euthanized. The postmortem histopathology confirmed the initial diagnosis of cryptococcosis and the presence of intraretinal Cryptococcus spp. To the authors' knowledge, this is the first report of Cryptococcus spp. induced exudative chorioretinitis in a ferret.

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Authors+Show Affiliations

Ropstad EO
Departament de Medicina i Cirurgia Animal, Facultat de Veterinària, Servei d'Oftalmologia, Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Barcelona, Spain. ernst.ropstad@veths.no
Leiva M
No affiliation info available
Peña T
No affiliation info available
Morera N
No affiliation info available
Martorell J
No affiliation info available

MeSH

AnimalsChorioretinitisCryptococcosisCryptococcus gattiiFerrets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21733068

Citation

Ropstad, Ernst-Otto, et al. "Cryptococcus Gattii Chorioretinitis in a Ferret." Veterinary Ophthalmology, vol. 14, no. 4, 2011, pp. 262-6.
Ropstad EO, Leiva M, Peña T, et al. Cryptococcus gattii chorioretinitis in a ferret. Vet Ophthalmol. 2011;14(4):262-6.
Ropstad, E. O., Leiva, M., Peña, T., Morera, N., & Martorell, J. (2011). Cryptococcus gattii chorioretinitis in a ferret. Veterinary Ophthalmology, 14(4), 262-6. https://doi.org/10.1111/j.1463-5224.2011.00885.x
Ropstad EO, et al. Cryptococcus Gattii Chorioretinitis in a Ferret. Vet Ophthalmol. 2011;14(4):262-6. PubMed PMID: 21733068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cryptococcus gattii chorioretinitis in a ferret. AU - Ropstad,Ernst-Otto, AU - Leiva,Marta, AU - Peña,Teresa, AU - Morera,Neus, AU - Martorell,Jaime, Y1 - 2011/04/19/ PY - 2011/7/8/entrez PY - 2011/7/8/pubmed PY - 2011/11/16/medline SP - 262 EP - 6 JF - Veterinary ophthalmology JO - Vet Ophthalmol VL - 14 IS - 4 N2 - Bilateral exudative chorioretinitis was diagnosed in an 18-month-old male neutered ferret (Mustela putorius furo) with a generalized Cryptococcus gattii infection confirmed by PCR. The animal was referred to the Ophthalmology Service of the Autonomous University of Barcelona (VTH-UAB) for acute onset blindness. Complete ophthalmic examination revealed absent menace response and dazzle reflex in both eyes (OU), as well as subretinal edema located in the tapetal fundus. At that time, the clinical ophthalmologic diagnosis was bilateral exudative chorioretinitis. Treatment with prednisone (0.5 mg/kg PO q24 h) was instituted in addition to the ongoing treatment with fluconazole (10 mg/kg PO q24 h). The following rechecks revealed secondary cataracts with subsequent lens subluxation and panretinal degeneration OU. Despite being blind and the poor prognosis of disseminate cryptococcosis, the patient remained active and in good body condition during 6 months after the initial diagnosis. At that time, the ferret showed ataxia, incontinence, and generalized pain. A magnetic resonance imaging study revealed a mass affecting the spine. The owners declined further investigations and the ferret was humanely euthanized. The postmortem histopathology confirmed the initial diagnosis of cryptococcosis and the presence of intraretinal Cryptococcus spp. To the authors' knowledge, this is the first report of Cryptococcus spp. induced exudative chorioretinitis in a ferret. SN - 1463-5224 UR - https://www.unboundmedicine.com/medline/citation/21733068/Cryptococcus_gattii_chorioretinitis_in_a_ferret_ L2 - https://doi.org/10.1111/j.1463-5224.2011.00885.x DB - PRIME DP - Unbound Medicine ER -