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Role of hepatitis E infection in acute on chronic liver failure in Egyptian patients.
Liver Int. 2011 Aug; 31(7):1001-5.LI

Abstract

BACKGROUND

The vast majority of patients who are referred to a specialist hepatological centre suffer from acute deterioration of their chronic liver disease. Yet, this entity of acute on chronic liver failure remains poorly defined.

AIM

The aim of the present study was to highlight the occurrence of hepatitis E viraemia by nested reverse transcriptase polymerase chain reaction (RT-PCR) in patients with acute on chronic liver failure.

MATERIALS AND METHODS

The study included 100 patients with acute on chronic liver disorders admitted to Mansoura University Hospital, Egypt. Blood samples were obtained from patients and sera were separated. Sera were subjected to a study of viral hepatitis markers for hepatitis A by IgM, for hepatitis B by S antigen and core IgM and for hepatitis C virus by IgG and RT-PCR for HCV. Liver function tests were evaluated including alanine transaminase, aspartate transaminase and bilirubin total and direct by an autoanalyser. Study for hepatitis E virus (HEV) was performed using a molecular technique. Nested RT-PCR was performed for each serum sample.

RESULTS

HEV RNA was detected in the sera of 13 patients (13%) of the patients with chronic liver disorders. The majority of the positive cases were among patients with cirrhosis (29.9%) followed by patients with HCC (15.4%). On multirisk analysis for the factors associated with the presence of HEV viraemia, younger age < 45 years and lower albumin level < 3.5 g/dl were significantly (P = 0.04, P = 0.03) associated with HEV viraemia.

DISCUSSION

From this study it appears that HEV viraemia is a common cause of acute on chronic liver disorders in Egypt.

CONCLUSION

There is no effective vaccine is available against HEV, mass awareness and preventive measures are important to the related.

Authors+Show Affiliations

Department of Clinical Pathology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt. may_s65@hotmail.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21733089

Citation

El Sayed Zaki, Maysaa, and Walaa Othman. "Role of Hepatitis E Infection in Acute On Chronic Liver Failure in Egyptian Patients." Liver International : Official Journal of the International Association for the Study of the Liver, vol. 31, no. 7, 2011, pp. 1001-5.
El Sayed Zaki M, Othman W. Role of hepatitis E infection in acute on chronic liver failure in Egyptian patients. Liver Int. 2011;31(7):1001-5.
El Sayed Zaki, M., & Othman, W. (2011). Role of hepatitis E infection in acute on chronic liver failure in Egyptian patients. Liver International : Official Journal of the International Association for the Study of the Liver, 31(7), 1001-5. https://doi.org/10.1111/j.1478-3231.2011.02521.x
El Sayed Zaki M, Othman W. Role of Hepatitis E Infection in Acute On Chronic Liver Failure in Egyptian Patients. Liver Int. 2011;31(7):1001-5. PubMed PMID: 21733089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of hepatitis E infection in acute on chronic liver failure in Egyptian patients. AU - El Sayed Zaki,Maysaa, AU - Othman,Walaa, Y1 - 2011/03/30/ PY - 2011/7/8/entrez PY - 2011/7/8/pubmed PY - 2011/12/13/medline SP - 1001 EP - 5 JF - Liver international : official journal of the International Association for the Study of the Liver JO - Liver Int VL - 31 IS - 7 N2 - BACKGROUND: The vast majority of patients who are referred to a specialist hepatological centre suffer from acute deterioration of their chronic liver disease. Yet, this entity of acute on chronic liver failure remains poorly defined. AIM: The aim of the present study was to highlight the occurrence of hepatitis E viraemia by nested reverse transcriptase polymerase chain reaction (RT-PCR) in patients with acute on chronic liver failure. MATERIALS AND METHODS: The study included 100 patients with acute on chronic liver disorders admitted to Mansoura University Hospital, Egypt. Blood samples were obtained from patients and sera were separated. Sera were subjected to a study of viral hepatitis markers for hepatitis A by IgM, for hepatitis B by S antigen and core IgM and for hepatitis C virus by IgG and RT-PCR for HCV. Liver function tests were evaluated including alanine transaminase, aspartate transaminase and bilirubin total and direct by an autoanalyser. Study for hepatitis E virus (HEV) was performed using a molecular technique. Nested RT-PCR was performed for each serum sample. RESULTS: HEV RNA was detected in the sera of 13 patients (13%) of the patients with chronic liver disorders. The majority of the positive cases were among patients with cirrhosis (29.9%) followed by patients with HCC (15.4%). On multirisk analysis for the factors associated with the presence of HEV viraemia, younger age < 45 years and lower albumin level < 3.5 g/dl were significantly (P = 0.04, P = 0.03) associated with HEV viraemia. DISCUSSION: From this study it appears that HEV viraemia is a common cause of acute on chronic liver disorders in Egypt. CONCLUSION: There is no effective vaccine is available against HEV, mass awareness and preventive measures are important to the related. SN - 1478-3231 UR - https://www.unboundmedicine.com/medline/citation/21733089/Role_of_hepatitis_E_infection_in_acute_on_chronic_liver_failure_in_Egyptian_patients_ L2 - https://doi.org/10.1111/j.1478-3231.2011.02521.x DB - PRIME DP - Unbound Medicine ER -