Tags

Type your tag names separated by a space and hit enter

Risk of stroke in 28,000 patients with celiac disease: a nationwide cohort study in Sweden.
J Stroke Cerebrovasc Dis 2012; 21(8):860-7JS

Abstract

BACKGROUND

Earlier studies on stroke in celiac disease (CD) have been underpowered, but a recent study suggested that childhood CD is associated with a 10-fold increased risk of death from stroke, although it was based on small numbers. We examined the risk of stroke in patients with biopsy-verified CD.

METHODS

We collected biopsy data from all 28 pathology departments in Sweden and identified 28,676 individuals with CD diagnosed between 1969 and 2007 (Marsh 3: villous atrophy). In the main analyses, we used Cox regression to estimate hazard ratios (HRs) for stroke in patients with CD compared with HRs for stroke in 141,806 sex- and age-matched controls.

RESULTS

During follow-up, there were 785 first-stroke diagnoses in patients with CD and 2937 in reference individuals. Patients with CD were at increased risk of stroke (HR 1.10; 95% confidence interval [CI] 1.01-1.19). HRs were similar for ischemic stroke and brain hemorrhage and were not affected by adjustment for type 1 diabetes, rheumatoid arthritis, use of medication against hypertension, or dyslipidemia. The absolute risk of stroke in patients with CD was 267 per 100,000 person-years (excess risk 24/100,000). The highest risk estimates occurred in the first year, with virtually no increased risk after more than 5 years of follow-up after CD diagnosis. The HR for stroke in childhood CD was 1.10 (95% CI 0.37-3.22).

CONCLUSIONS

Patients with CD are at only a small increased risk of stroke, which persists only for a brief period after diagnosis. CD does not seem to be a major risk factor for stroke.

Authors+Show Affiliations

Department of Pediatrics, Örebro University Hospital, Örebro, Sweden. jonasludvigsson@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21733721

Citation

Ludvigsson, Jonas F., et al. "Risk of Stroke in 28,000 Patients With Celiac Disease: a Nationwide Cohort Study in Sweden." Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, vol. 21, no. 8, 2012, pp. 860-7.
Ludvigsson JF, West J, Card T, et al. Risk of stroke in 28,000 patients with celiac disease: a nationwide cohort study in Sweden. J Stroke Cerebrovasc Dis. 2012;21(8):860-7.
Ludvigsson, J. F., West, J., Card, T., & Appelros, P. (2012). Risk of stroke in 28,000 patients with celiac disease: a nationwide cohort study in Sweden. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, 21(8), pp. 860-7. doi:10.1016/j.jstrokecerebrovasdis.2011.05.008.
Ludvigsson JF, et al. Risk of Stroke in 28,000 Patients With Celiac Disease: a Nationwide Cohort Study in Sweden. J Stroke Cerebrovasc Dis. 2012;21(8):860-7. PubMed PMID: 21733721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of stroke in 28,000 patients with celiac disease: a nationwide cohort study in Sweden. AU - Ludvigsson,Jonas F, AU - West,Joe, AU - Card,Tim, AU - Appelros,Peter, Y1 - 2011/07/05/ PY - 2010/12/02/received PY - 2011/05/07/revised PY - 2011/05/07/accepted PY - 2011/7/8/entrez PY - 2011/7/8/pubmed PY - 2013/4/24/medline SP - 860 EP - 7 JF - Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association JO - J Stroke Cerebrovasc Dis VL - 21 IS - 8 N2 - BACKGROUND: Earlier studies on stroke in celiac disease (CD) have been underpowered, but a recent study suggested that childhood CD is associated with a 10-fold increased risk of death from stroke, although it was based on small numbers. We examined the risk of stroke in patients with biopsy-verified CD. METHODS: We collected biopsy data from all 28 pathology departments in Sweden and identified 28,676 individuals with CD diagnosed between 1969 and 2007 (Marsh 3: villous atrophy). In the main analyses, we used Cox regression to estimate hazard ratios (HRs) for stroke in patients with CD compared with HRs for stroke in 141,806 sex- and age-matched controls. RESULTS: During follow-up, there were 785 first-stroke diagnoses in patients with CD and 2937 in reference individuals. Patients with CD were at increased risk of stroke (HR 1.10; 95% confidence interval [CI] 1.01-1.19). HRs were similar for ischemic stroke and brain hemorrhage and were not affected by adjustment for type 1 diabetes, rheumatoid arthritis, use of medication against hypertension, or dyslipidemia. The absolute risk of stroke in patients with CD was 267 per 100,000 person-years (excess risk 24/100,000). The highest risk estimates occurred in the first year, with virtually no increased risk after more than 5 years of follow-up after CD diagnosis. The HR for stroke in childhood CD was 1.10 (95% CI 0.37-3.22). CONCLUSIONS: Patients with CD are at only a small increased risk of stroke, which persists only for a brief period after diagnosis. CD does not seem to be a major risk factor for stroke. SN - 1532-8511 UR - https://www.unboundmedicine.com/medline/citation/21733721/Risk_of_stroke_in_28000_patients_with_celiac_disease:_a_nationwide_cohort_study_in_Sweden_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1052-3057(11)00115-7 DB - PRIME DP - Unbound Medicine ER -