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Correlation between eicosanoids in bronchoalveolar lavage fluid and in exhaled breath condensate.
Dis Markers. 2011; 30(5):213-20.DM

Abstract

Exhaled breath condensate (EBC) has been increasingly used as a new and non-invasive method to study airway inflammation. In this study we have compared the concentrations of lipid mediators in EBC with concentrations in bronchoalveolar lavage fluid (BALF). We included 37 patients undergoing bronchoscopy (12 sarcoidosis, 12 COPD, 6 lung cancer, 5 chronic cough, 1 Wegener's granulomatosis, 1 sclerodermia). Patients were not allowed to have exacerbation or any change in concomitant medication for at least 4 weeks prior to the study. In all patients, EBC was collected immediately prior to the bronchoscopy. The levels of cys-LTs, LTB<formula>_{4}</formula>, 8-isoprostane were significantly higher in BALF compared to EBC (p < 0.0001, p< 0.001, p< 0.0001 for cys-LTs, LTB4, 8-isoprostane respectively). Moreover, there was a strong positive correlation between both leukotriene B<formula>_{4}</formula> and 8-isoprostane in BALF and EBC (r=0.53 and r=0.79, p< 0.01, respectively) in patients with sarcoidosis and COPD but there was no correlation between eicosanoids BALF and EBC in patients with chronic cough and lung cancer. This is the first study to compare EBC and BALF in different lung diseases which demonstrated significant correlations between the levels of eicosanoids in BALF and EBC in patients with COPD and sarcoidosis. EBC may be useful in measuring inflammation in several inflammatory lung diseases.

Authors+Show Affiliations

Department of Pneumology & Allergology, Medical University of Lodz, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21734340

Citation

Antczak, Adam, et al. "Correlation Between Eicosanoids in Bronchoalveolar Lavage Fluid and in Exhaled Breath Condensate." Disease Markers, vol. 30, no. 5, 2011, pp. 213-20.
Antczak A, Piotrowski W, Marczak J, et al. Correlation between eicosanoids in bronchoalveolar lavage fluid and in exhaled breath condensate. Dis Markers. 2011;30(5):213-20.
Antczak, A., Piotrowski, W., Marczak, J., Ciebiada, M., Gorski, P., & Barnes, P. J. (2011). Correlation between eicosanoids in bronchoalveolar lavage fluid and in exhaled breath condensate. Disease Markers, 30(5), 213-20. https://doi.org/10.3233/DMA-2011-0776
Antczak A, et al. Correlation Between Eicosanoids in Bronchoalveolar Lavage Fluid and in Exhaled Breath Condensate. Dis Markers. 2011;30(5):213-20. PubMed PMID: 21734340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between eicosanoids in bronchoalveolar lavage fluid and in exhaled breath condensate. AU - Antczak,Adam, AU - Piotrowski,Wojciech, AU - Marczak,Jerzy, AU - Ciebiada,Maciej, AU - Gorski,Pawel, AU - Barnes,Peter J, PY - 2011/7/8/entrez PY - 2011/7/8/pubmed PY - 2011/10/28/medline SP - 213 EP - 20 JF - Disease markers JO - Dis Markers VL - 30 IS - 5 N2 - Exhaled breath condensate (EBC) has been increasingly used as a new and non-invasive method to study airway inflammation. In this study we have compared the concentrations of lipid mediators in EBC with concentrations in bronchoalveolar lavage fluid (BALF). We included 37 patients undergoing bronchoscopy (12 sarcoidosis, 12 COPD, 6 lung cancer, 5 chronic cough, 1 Wegener's granulomatosis, 1 sclerodermia). Patients were not allowed to have exacerbation or any change in concomitant medication for at least 4 weeks prior to the study. In all patients, EBC was collected immediately prior to the bronchoscopy. The levels of cys-LTs, LTB<formula>_{4}</formula>, 8-isoprostane were significantly higher in BALF compared to EBC (p < 0.0001, p< 0.001, p< 0.0001 for cys-LTs, LTB4, 8-isoprostane respectively). Moreover, there was a strong positive correlation between both leukotriene B<formula>_{4}</formula> and 8-isoprostane in BALF and EBC (r=0.53 and r=0.79, p< 0.01, respectively) in patients with sarcoidosis and COPD but there was no correlation between eicosanoids BALF and EBC in patients with chronic cough and lung cancer. This is the first study to compare EBC and BALF in different lung diseases which demonstrated significant correlations between the levels of eicosanoids in BALF and EBC in patients with COPD and sarcoidosis. EBC may be useful in measuring inflammation in several inflammatory lung diseases. SN - 1875-8630 UR - https://www.unboundmedicine.com/medline/citation/21734340/Correlation_between_eicosanoids_in_bronchoalveolar_lavage_fluid_and_in_exhaled_breath_condensate_ L2 - https://doi.org/10.3233/DMA-2011-0776 DB - PRIME DP - Unbound Medicine ER -