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Cell and tissue interactions of Treponema pallidum in primary and secondary syphilitic skin lesions: an ultrastructural study of serial sections.
Ultrastruct Pathol. 2013 Feb; 37(1):36-42.UP

Abstract

There are limited reports on the ultrastructure of syphilis skin lesions. The aim of this study has been to perform an electron microscopic investigation of the morphology and the tissue distribution of treponemes in primary and secondary cutaneous lesions. Three cases of primary syphilitic chancre and one case of secondary syphilis were included. Prominent epidermal abnormalities in the primary chancre and a perivascular inflammatory infiltrate in the secondary lesion were found by light microscopy. Ultrastructurally, spirochetes were located mainly in the blood vessel walls and dermal tissue of the chancre lesions. In the secondary syphilis case, spirochetes were more abundant between epidermal keratinocytes. Most of them adjusted to the intercellular spaces. Occasionally, the electron microscopy images were highly suggestive of an intracellular location. Both the ultrastructural and immunohistochemical examination of the primary and secondary syphilis lesions showed a paradoxical distribution of the causative microorganisms compared to the light microscopic changes. In addition, the ultrastructural findings strongly suggest that Treponema pallidum subspecies pallidum invades tissues, not only through an intercellular, but also through a transcellular pathway.

Authors+Show Affiliations

Department of Pathology, Hospital del Mar, and Autonomous University of Barcelona, Barcelona, Spain. jonpiter77@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21736426

Citation

Juanpere-Rodero, Nuria, et al. "Cell and Tissue Interactions of Treponema Pallidum in Primary and Secondary Syphilitic Skin Lesions: an Ultrastructural Study of Serial Sections." Ultrastructural Pathology, vol. 37, no. 1, 2013, pp. 36-42.
Juanpere-Rodero N, Martin-Ezquerra G, Fernandez-Casado A, et al. Cell and tissue interactions of Treponema pallidum in primary and secondary syphilitic skin lesions: an ultrastructural study of serial sections. Ultrastruct Pathol. 2013;37(1):36-42.
Juanpere-Rodero, N., Martin-Ezquerra, G., Fernandez-Casado, A., Magan-Perea, L., Garcia-Alguacil, M. A., Barranco-Sanz, C., Serrano-Figueras, S., Pujol-Vallverdu, R. M., & Lloreta-Trull, J. (2013). Cell and tissue interactions of Treponema pallidum in primary and secondary syphilitic skin lesions: an ultrastructural study of serial sections. Ultrastructural Pathology, 37(1), 36-42. https://doi.org/10.3109/01913123.2011.584498
Juanpere-Rodero N, et al. Cell and Tissue Interactions of Treponema Pallidum in Primary and Secondary Syphilitic Skin Lesions: an Ultrastructural Study of Serial Sections. Ultrastruct Pathol. 2013;37(1):36-42. PubMed PMID: 21736426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cell and tissue interactions of Treponema pallidum in primary and secondary syphilitic skin lesions: an ultrastructural study of serial sections. AU - Juanpere-Rodero,Nuria, AU - Martin-Ezquerra,Gemma, AU - Fernandez-Casado,Alejandro, AU - Magan-Perea,Luis, AU - Garcia-Alguacil,Maria A, AU - Barranco-Sanz,Carlos, AU - Serrano-Figueras,Sergio, AU - Pujol-Vallverdu,Ramon M, AU - Lloreta-Trull,Josep, Y1 - 2011/07/07/ PY - 2011/7/9/entrez PY - 2011/7/9/pubmed PY - 2013/7/28/medline SP - 36 EP - 42 JF - Ultrastructural pathology JO - Ultrastruct Pathol VL - 37 IS - 1 N2 - There are limited reports on the ultrastructure of syphilis skin lesions. The aim of this study has been to perform an electron microscopic investigation of the morphology and the tissue distribution of treponemes in primary and secondary cutaneous lesions. Three cases of primary syphilitic chancre and one case of secondary syphilis were included. Prominent epidermal abnormalities in the primary chancre and a perivascular inflammatory infiltrate in the secondary lesion were found by light microscopy. Ultrastructurally, spirochetes were located mainly in the blood vessel walls and dermal tissue of the chancre lesions. In the secondary syphilis case, spirochetes were more abundant between epidermal keratinocytes. Most of them adjusted to the intercellular spaces. Occasionally, the electron microscopy images were highly suggestive of an intracellular location. Both the ultrastructural and immunohistochemical examination of the primary and secondary syphilis lesions showed a paradoxical distribution of the causative microorganisms compared to the light microscopic changes. In addition, the ultrastructural findings strongly suggest that Treponema pallidum subspecies pallidum invades tissues, not only through an intercellular, but also through a transcellular pathway. SN - 1521-0758 UR - https://www.unboundmedicine.com/medline/citation/21736426/Cell_and_tissue_interactions_of_Treponema_pallidum_in_primary_and_secondary_syphilitic_skin_lesions:_an_ultrastructural_study_of_serial_sections_ L2 - https://www.tandfonline.com/doi/full/10.3109/01913123.2011.584498 DB - PRIME DP - Unbound Medicine ER -