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Dietary folate, vitamin B6, vitamin B12 and methionine intake and the risk of breast cancer by oestrogen and progesterone receptor status.

Abstract

Few studies have evaluated the relationship between the consumption of dietary folate and one-carbon metabolism-related nutrients and breast cancer risk defined by oestrogen receptor (ER) and progesterone receptor (PR) status. The objective of the present study was to examine the associations between dietary folate, vitamin B6, vitamin B12, and methionine intake and the risk of breast cancer by ER and PR status among Chinese women in Guangdong. A hospital-based case-control study was conducted from June 2007 to August 2008, with 438 cases and 438 age (5-year interval)- and residence (rural/urban)-matched controls. Dietary intake information was assessed using a validated FFQ administered through a face-to-face interview. Unconditional logistic regression models were used to calculate multivariate-adjusted OR and 95 % CI. A significant inverse association was found between dietary folate and vitamin B6 intake and breast cancer risk. The adjusted OR of the highest v. the lowest quartile were 0·32 (95 % CI 0·21, 0·49; P(trend) < 0·001) for dietary folate and 0·46 (95 % CI 0·30, 0·69; P(trend) < 0·001) for vitamin B6. No associations were observed for vitamin B12 and methionine intake. A significant inverse association between dietary folate intake and breast cancer risk was observed in all subtypes of ER and PR status. These findings suggest that dietary folate and vitamin B6 intakes were inversely associated with breast cancer risk. The inverse association did not differ by ER and/or PR status.

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  • Authors+Show Affiliations

    ,

    Centre of Research and Promotion of Women's Health, 4th Floor, School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin NT, Hong Kong Special Administrative Region, People's Republic of China.

    , , , ,

    Source

    The British journal of nutrition 106:6 2011 Sep pg 936-43

    MeSH

    Adult
    Age Factors
    Aged
    Breast Neoplasms
    Case-Control Studies
    China
    Diet
    Female
    Folic Acid
    Humans
    Methionine
    Middle Aged
    Multivariate Analysis
    Receptors, Estrogen
    Receptors, Progesterone
    Regression Analysis
    Rural Population
    Urban Population
    Vitamin B 12
    Vitamin B 6

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21736840

    Citation

    Zhang, Cai-Xia, et al. "Dietary Folate, Vitamin B6, Vitamin B12 and Methionine Intake and the Risk of Breast Cancer By Oestrogen and Progesterone Receptor Status." The British Journal of Nutrition, vol. 106, no. 6, 2011, pp. 936-43.
    Zhang CX, Ho SC, Chen YM, et al. Dietary folate, vitamin B6, vitamin B12 and methionine intake and the risk of breast cancer by oestrogen and progesterone receptor status. Br J Nutr. 2011;106(6):936-43.
    Zhang, C. X., Ho, S. C., Chen, Y. M., Lin, F. Y., Fu, J. H., & Cheng, S. Z. (2011). Dietary folate, vitamin B6, vitamin B12 and methionine intake and the risk of breast cancer by oestrogen and progesterone receptor status. The British Journal of Nutrition, 106(6), pp. 936-43. doi:10.1017/S0007114511001140.
    Zhang CX, et al. Dietary Folate, Vitamin B6, Vitamin B12 and Methionine Intake and the Risk of Breast Cancer By Oestrogen and Progesterone Receptor Status. Br J Nutr. 2011;106(6):936-43. PubMed PMID: 21736840.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary folate, vitamin B6, vitamin B12 and methionine intake and the risk of breast cancer by oestrogen and progesterone receptor status. AU - Zhang,Cai-Xia, AU - Ho,Suzanne C, AU - Chen,Yu-Ming, AU - Lin,Fang-Yu, AU - Fu,Jian-Hua, AU - Cheng,Shou-Zhen, Y1 - 2011/05/16/ PY - 2011/7/9/entrez PY - 2011/7/9/pubmed PY - 2011/11/9/medline SP - 936 EP - 43 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 106 IS - 6 N2 - Few studies have evaluated the relationship between the consumption of dietary folate and one-carbon metabolism-related nutrients and breast cancer risk defined by oestrogen receptor (ER) and progesterone receptor (PR) status. The objective of the present study was to examine the associations between dietary folate, vitamin B6, vitamin B12, and methionine intake and the risk of breast cancer by ER and PR status among Chinese women in Guangdong. A hospital-based case-control study was conducted from June 2007 to August 2008, with 438 cases and 438 age (5-year interval)- and residence (rural/urban)-matched controls. Dietary intake information was assessed using a validated FFQ administered through a face-to-face interview. Unconditional logistic regression models were used to calculate multivariate-adjusted OR and 95 % CI. A significant inverse association was found between dietary folate and vitamin B6 intake and breast cancer risk. The adjusted OR of the highest v. the lowest quartile were 0·32 (95 % CI 0·21, 0·49; P(trend) < 0·001) for dietary folate and 0·46 (95 % CI 0·30, 0·69; P(trend) < 0·001) for vitamin B6. No associations were observed for vitamin B12 and methionine intake. A significant inverse association between dietary folate intake and breast cancer risk was observed in all subtypes of ER and PR status. These findings suggest that dietary folate and vitamin B6 intakes were inversely associated with breast cancer risk. The inverse association did not differ by ER and/or PR status. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/21736840/Dietary_folate_vitamin_B6_vitamin_B12_and_methionine_intake_and_the_risk_of_breast_cancer_by_oestrogen_and_progesterone_receptor_status_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511001140/type/journal_article DB - PRIME DP - Unbound Medicine ER -