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Effects of benzodiazepines on passive avoidance response and latent learning in mice: relationship to benzodiazepine receptors and the cholinergic neuronal system.
J Pharmacol Exp Ther. 1990 Nov; 255(2):789-94.JP

Abstract

The effects of benzodiazepines on learning and memory were investigated, using passive avoidance and latent learning tasks, with particular attention being paid to the possible involvement of benzodiazepine receptors and the cholinergic neuronal system. Benzodiazepines such as diazepam, nitrazepam and chlordiazepoxide (CDP) impaired the passive avoidance response when administered before training, but not when administered immediately after training or before the retention test. CDP also impaired latent learning in the water finding task. State-dependent learning was not observed with CDP at the dose used. A benzodiazepine inverse agonist, Ro 15-4513, and a benzodiazepine antagonist, Ro 15-1788, completely and partially reversed, respectively, the disruptive effects of CDP on learning and memory at the doses which did not enhance learning and memory. The disruptive effects of CDP on learning and memory were partially antagonized by a choline esterase inhibitor, physostigmine, and by a blocker for muscarinic acetylcholine receptors, scopolamine, at the doses which increase acetylcholine release. These results suggest that benzodiazepines induce disruptive effects on learning and memory through benzodiazepine receptors, and that benzodiazepine-induced impairment of learning and memory is, at least in part, the result of the dysfunction of the cholinergic neuronal system.

Authors+Show Affiliations

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2173758

Citation

Nabeshima, T, et al. "Effects of Benzodiazepines On Passive Avoidance Response and Latent Learning in Mice: Relationship to Benzodiazepine Receptors and the Cholinergic Neuronal System." The Journal of Pharmacology and Experimental Therapeutics, vol. 255, no. 2, 1990, pp. 789-94.
Nabeshima T, Tohyama K, Ichihara K, et al. Effects of benzodiazepines on passive avoidance response and latent learning in mice: relationship to benzodiazepine receptors and the cholinergic neuronal system. J Pharmacol Exp Ther. 1990;255(2):789-94.
Nabeshima, T., Tohyama, K., Ichihara, K., & Kameyama, T. (1990). Effects of benzodiazepines on passive avoidance response and latent learning in mice: relationship to benzodiazepine receptors and the cholinergic neuronal system. The Journal of Pharmacology and Experimental Therapeutics, 255(2), 789-94.
Nabeshima T, et al. Effects of Benzodiazepines On Passive Avoidance Response and Latent Learning in Mice: Relationship to Benzodiazepine Receptors and the Cholinergic Neuronal System. J Pharmacol Exp Ther. 1990;255(2):789-94. PubMed PMID: 2173758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of benzodiazepines on passive avoidance response and latent learning in mice: relationship to benzodiazepine receptors and the cholinergic neuronal system. AU - Nabeshima,T, AU - Tohyama,K, AU - Ichihara,K, AU - Kameyama,T, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 789 EP - 94 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 255 IS - 2 N2 - The effects of benzodiazepines on learning and memory were investigated, using passive avoidance and latent learning tasks, with particular attention being paid to the possible involvement of benzodiazepine receptors and the cholinergic neuronal system. Benzodiazepines such as diazepam, nitrazepam and chlordiazepoxide (CDP) impaired the passive avoidance response when administered before training, but not when administered immediately after training or before the retention test. CDP also impaired latent learning in the water finding task. State-dependent learning was not observed with CDP at the dose used. A benzodiazepine inverse agonist, Ro 15-4513, and a benzodiazepine antagonist, Ro 15-1788, completely and partially reversed, respectively, the disruptive effects of CDP on learning and memory at the doses which did not enhance learning and memory. The disruptive effects of CDP on learning and memory were partially antagonized by a choline esterase inhibitor, physostigmine, and by a blocker for muscarinic acetylcholine receptors, scopolamine, at the doses which increase acetylcholine release. These results suggest that benzodiazepines induce disruptive effects on learning and memory through benzodiazepine receptors, and that benzodiazepine-induced impairment of learning and memory is, at least in part, the result of the dysfunction of the cholinergic neuronal system. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/2173758/Effects_of_benzodiazepines_on_passive_avoidance_response_and_latent_learning_in_mice:_relationship_to_benzodiazepine_receptors_and_the_cholinergic_neuronal_system_ DB - PRIME DP - Unbound Medicine ER -