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Hypovitaminosis D in geriatric inpatients: a marker of severity of chronic diseases.
Aging Clin Exp Res 2012; 24(2):188-92AC

Abstract

BACKGROUND AND AIMS

Hypovitaminosis D is associated with adverse health outcomes including several bone and non-bone chronic diseases. It remains unclear whether hypovitaminosis D leads to more numerous or more severe chronic diseases. Our aim was to determine whether there was an association between serum 25-hydroxyvitamin D deficiency (i.e., 25OHD ≤25 nmol/L) and, respectively, the number and severity of chronic diseases assessed with the Kaplan- Feinstein index (KFI) among geriatric inpatients.

METHODS

Two hundred and forty older Caucasian adults admitted between December 2008 and September 2009 to the geriatric acute care unit of Angers University Hospital, France (mean 84.6±0.4 years; 68.8% women) were included in this cross-sectional study. Serum 25OHD, KFI score and number of chronic diseases (i.e., diseases lasting at least 3 months or running a course with minimal change, whatever their nature or site) were assessed. Subjects were divided into 2 groups according to 25OHD concentration (either deficient for 25OHD ≤25 nmol/L, or non-deficient for 25OHD >25 nmol/L). Age, gender, use of vitamin D supplements, number of chronic diseases, serum parathyroid hormone and season tested were used as potential confounders.

RESULTS

Mean serum 25OHD concentration was 35.2 ± 1.7 nmol/L. The 102 (42.5%) subjects with 25OHD deficiency had higher KFI compared with their counterparts (p=0.008). Vitamin D deficiency was not significantly associated with the number of chronic diseases (adjusted β=-0.37 with p=0.216), but with KFI (unadjusted β=1.33 with p=0.008; adjusted β=1.37 with p=0.010).

CONCLUSIONS

Irrespective of the number of chronic diseases, 25OHD deficiency was associated with the severity of chronic diseases.

Authors+Show Affiliations

Department of Internal Medicine and Geriatrics, Angers University Hospital, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21737996

Citation

Beauchet, Olivier, et al. "Hypovitaminosis D in Geriatric Inpatients: a Marker of Severity of Chronic Diseases." Aging Clinical and Experimental Research, vol. 24, no. 2, 2012, pp. 188-92.
Beauchet O, Hélard L, Montero-Odasso M, et al. Hypovitaminosis D in geriatric inpatients: a marker of severity of chronic diseases. Aging Clin Exp Res. 2012;24(2):188-92.
Beauchet, O., Hélard, L., Montero-Odasso, M., de Decker, L., Berrut, G., & Annweiler, C. (2012). Hypovitaminosis D in geriatric inpatients: a marker of severity of chronic diseases. Aging Clinical and Experimental Research, 24(2), pp. 188-92. doi:10.3275/7838.
Beauchet O, et al. Hypovitaminosis D in Geriatric Inpatients: a Marker of Severity of Chronic Diseases. Aging Clin Exp Res. 2012;24(2):188-92. PubMed PMID: 21737996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypovitaminosis D in geriatric inpatients: a marker of severity of chronic diseases. AU - Beauchet,Olivier, AU - Hélard,Lise, AU - Montero-Odasso,Manuel, AU - de Decker,Laure, AU - Berrut,Gilles, AU - Annweiler,Cédric, Y1 - 2011/07/05/ PY - 2011/7/9/entrez PY - 2011/7/9/pubmed PY - 2013/3/30/medline SP - 188 EP - 92 JF - Aging clinical and experimental research JO - Aging Clin Exp Res VL - 24 IS - 2 N2 - BACKGROUND AND AIMS: Hypovitaminosis D is associated with adverse health outcomes including several bone and non-bone chronic diseases. It remains unclear whether hypovitaminosis D leads to more numerous or more severe chronic diseases. Our aim was to determine whether there was an association between serum 25-hydroxyvitamin D deficiency (i.e., 25OHD ≤25 nmol/L) and, respectively, the number and severity of chronic diseases assessed with the Kaplan- Feinstein index (KFI) among geriatric inpatients. METHODS: Two hundred and forty older Caucasian adults admitted between December 2008 and September 2009 to the geriatric acute care unit of Angers University Hospital, France (mean 84.6±0.4 years; 68.8% women) were included in this cross-sectional study. Serum 25OHD, KFI score and number of chronic diseases (i.e., diseases lasting at least 3 months or running a course with minimal change, whatever their nature or site) were assessed. Subjects were divided into 2 groups according to 25OHD concentration (either deficient for 25OHD ≤25 nmol/L, or non-deficient for 25OHD >25 nmol/L). Age, gender, use of vitamin D supplements, number of chronic diseases, serum parathyroid hormone and season tested were used as potential confounders. RESULTS: Mean serum 25OHD concentration was 35.2 ± 1.7 nmol/L. The 102 (42.5%) subjects with 25OHD deficiency had higher KFI compared with their counterparts (p=0.008). Vitamin D deficiency was not significantly associated with the number of chronic diseases (adjusted β=-0.37 with p=0.216), but with KFI (unadjusted β=1.33 with p=0.008; adjusted β=1.37 with p=0.010). CONCLUSIONS: Irrespective of the number of chronic diseases, 25OHD deficiency was associated with the severity of chronic diseases. SN - 1720-8319 UR - https://www.unboundmedicine.com/medline/citation/21737996/Hypovitaminosis_D_in_geriatric_inpatients:_a_marker_of_severity_of_chronic_diseases_ L2 - https://medlineplus.gov/vitamind.html DB - PRIME DP - Unbound Medicine ER -