Tags

Type your tag names separated by a space and hit enter

Sixty-two severe and critical patients with 2009 influenza A (H1N1) in Shanghai, China.
Chin Med J (Engl). 2011 Jun; 124(11):1662-6.CM

Abstract

BACKGROUND

Pandemic influenza A (H1N1) emerged rapidly in China in May 2009. Preliminary comparisons with seasonal influenza suggest that pandemic 2009 influenza A (H1N1) disproportionately affects younger ages and causes generally mild disease. To characterize disease progress, comorbidities, and treatment outcomes among consecutive severe and critically ill patients in a hospital served as a reference center for the care of patients with H1N1 in Shanghai, China.

METHODS

A retrospective study on 62 severe and critically ill patients with 2009 influenza A (H1N1) was conducted in Shanghai Public Health Clinical Center. Demographic data, symptoms, comorbidities, disease progression, treatments, and clinical outcomes were collected for analysis.

RESULTS

Sixty-two severe or critically ill patients were admitted to the hospital with confirmed 2009 influenza A (H1N1) infection. The median age of the study cohort was 40 years old with a range from 18 years to 75 years, and 67.7% were males. All patients presented with fever and respiratory symptoms. At presentation, 34 patients (54.8%) had comorbidities such as smoking (29.0%), hypertension (29.0%) and hepatitis B virus infection (9.7%). The median time from symptom onset to hospital admission was 6 days (interquartile-range 3 - 14 days) and 23 critically ill patients were admitted to Intensive Care Unit after admission. All the patients received neuraminidase inhibitors (oseltaminir), while 60 patients (96.7%) were treated with antibiotics, and 39 (62.9%) with corticosteroids. Twenty-three critical cases received noninvasive mechanical ventilation on the first day of admission, and 3 of them ultimately required invasive ventilation. Four death reports (6.5%) were filed within the first 14 days from the onset of critical illness with the primary causes of severe acute respiratory distress syndrome, hypoxemia, or complications, secondary infection and sepsis, pyopneumothorax and stroke.

CONCLUSIONS

Severe illness from 2009 influenza A (H1N1) infection in Shanghai occurred among young individuals. Critical cases were associated with severe hypoxemia, multisystem organ failure, and a requirement for mechanical ventilation. Most patients had a good prognosis.

Authors+Show Affiliations

Department of Infectious Disease, Shanghai Public Health Clinical Center, Shanghai 201508, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21740773

Citation

Liu, Li, et al. "Sixty-two Severe and Critical Patients With 2009 Influenza a (H1N1) in Shanghai, China." Chinese Medical Journal, vol. 124, no. 11, 2011, pp. 1662-6.
Liu L, Zhang RF, Lu HZ, et al. Sixty-two severe and critical patients with 2009 influenza A (H1N1) in Shanghai, China. Chin Med J. 2011;124(11):1662-6.
Liu, L., Zhang, R. F., Lu, H. Z., Lu, S. H., Huang, Q., Xiong, Y. Y., Xi, X. H., & Zhang, Z. Y. (2011). Sixty-two severe and critical patients with 2009 influenza A (H1N1) in Shanghai, China. Chinese Medical Journal, 124(11), 1662-6.
Liu L, et al. Sixty-two Severe and Critical Patients With 2009 Influenza a (H1N1) in Shanghai, China. Chin Med J. 2011;124(11):1662-6. PubMed PMID: 21740773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sixty-two severe and critical patients with 2009 influenza A (H1N1) in Shanghai, China. AU - Liu,Li, AU - Zhang,Ren-Fang, AU - Lu,Hong-Zhou, AU - Lu,Shui-Hua, AU - Huang,Qin, AU - Xiong,Yan-Ying, AU - Xi,Xiu-Hong, AU - Zhang,Zhi-Yong, PY - 2011/7/12/entrez PY - 2011/7/12/pubmed PY - 2011/12/13/medline SP - 1662 EP - 6 JF - Chinese medical journal JO - Chin. Med. J. VL - 124 IS - 11 N2 - BACKGROUND: Pandemic influenza A (H1N1) emerged rapidly in China in May 2009. Preliminary comparisons with seasonal influenza suggest that pandemic 2009 influenza A (H1N1) disproportionately affects younger ages and causes generally mild disease. To characterize disease progress, comorbidities, and treatment outcomes among consecutive severe and critically ill patients in a hospital served as a reference center for the care of patients with H1N1 in Shanghai, China. METHODS: A retrospective study on 62 severe and critically ill patients with 2009 influenza A (H1N1) was conducted in Shanghai Public Health Clinical Center. Demographic data, symptoms, comorbidities, disease progression, treatments, and clinical outcomes were collected for analysis. RESULTS: Sixty-two severe or critically ill patients were admitted to the hospital with confirmed 2009 influenza A (H1N1) infection. The median age of the study cohort was 40 years old with a range from 18 years to 75 years, and 67.7% were males. All patients presented with fever and respiratory symptoms. At presentation, 34 patients (54.8%) had comorbidities such as smoking (29.0%), hypertension (29.0%) and hepatitis B virus infection (9.7%). The median time from symptom onset to hospital admission was 6 days (interquartile-range 3 - 14 days) and 23 critically ill patients were admitted to Intensive Care Unit after admission. All the patients received neuraminidase inhibitors (oseltaminir), while 60 patients (96.7%) were treated with antibiotics, and 39 (62.9%) with corticosteroids. Twenty-three critical cases received noninvasive mechanical ventilation on the first day of admission, and 3 of them ultimately required invasive ventilation. Four death reports (6.5%) were filed within the first 14 days from the onset of critical illness with the primary causes of severe acute respiratory distress syndrome, hypoxemia, or complications, secondary infection and sepsis, pyopneumothorax and stroke. CONCLUSIONS: Severe illness from 2009 influenza A (H1N1) infection in Shanghai occurred among young individuals. Critical cases were associated with severe hypoxemia, multisystem organ failure, and a requirement for mechanical ventilation. Most patients had a good prognosis. SN - 2542-5641 UR - https://www.unboundmedicine.com/medline/citation/21740773/Sixty_two_severe_and_critical_patients_with_2009_influenza_A__H1N1__in_Shanghai_China_ L2 - http://Insights.ovid.com/pubmed?pmid=21740773 DB - PRIME DP - Unbound Medicine ER -