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Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo.
Mol Cell Neurosci. 2011 Sep; 48(1):72-81.MC

Abstract

The sphingosine 1-phosphate (S1P) receptor modulators have emerged as a new therapeutic opportunity paradigm for the treatment of immune-mediated demyelinating diseases such as multiple sclerosis (MS). The S1P analog fingolimod (FTY720) has been shown to alleviate disease burden in immune-mediated animal models of MS, and has been approved for treatment in clinical trials in patients with MS in the United States. While the immunological effects of FTY720 are well established, there is controversy in the literature regarding the contribution of FTY720 on myelin repair. Here, we directly assessed the impact of FTY720 on myelin repair in cuprizone and lysolecithin (LPC) demyelination models that have a minimal immunological component. FTY720 failed to promote remyelination in either animal model. These studies suggest that while FTY720 may be effective at modulating the immunological attack in MS, it may benefit from an add-on therapy to enhance the myelin repair required for long-term functional restoration in MS.

Authors+Show Affiliations

Biogen Idec Inc, Neuro-Discovery Biology, 14 Cambridge Center, Cambridge, Massachusetts 02142, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21740973

Citation

Hu, Yinghui, et al. "Sphingosine 1-phosphate Receptor Modulator Fingolimod (FTY720) Does Not Promote Remyelination in Vivo." Molecular and Cellular Neurosciences, vol. 48, no. 1, 2011, pp. 72-81.
Hu Y, Lee X, Ji B, et al. Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo. Mol Cell Neurosci. 2011;48(1):72-81.
Hu, Y., Lee, X., Ji, B., Guckian, K., Apicco, D., Pepinsky, R. B., Miller, R. H., & Mi, S. (2011). Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo. Molecular and Cellular Neurosciences, 48(1), 72-81. https://doi.org/10.1016/j.mcn.2011.06.007
Hu Y, et al. Sphingosine 1-phosphate Receptor Modulator Fingolimod (FTY720) Does Not Promote Remyelination in Vivo. Mol Cell Neurosci. 2011;48(1):72-81. PubMed PMID: 21740973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo. AU - Hu,Yinghui, AU - Lee,Xinhua, AU - Ji,Benxiu, AU - Guckian,Kevin, AU - Apicco,Daniel, AU - Pepinsky,R Blake, AU - Miller,Robert H, AU - Mi,Sha, Y1 - 2011/06/24/ PY - 2011/03/09/received PY - 2011/05/19/revised PY - 2011/06/08/accepted PY - 2011/7/12/entrez PY - 2011/7/12/pubmed PY - 2012/2/18/medline SP - 72 EP - 81 JF - Molecular and cellular neurosciences JO - Mol. Cell. Neurosci. VL - 48 IS - 1 N2 - The sphingosine 1-phosphate (S1P) receptor modulators have emerged as a new therapeutic opportunity paradigm for the treatment of immune-mediated demyelinating diseases such as multiple sclerosis (MS). The S1P analog fingolimod (FTY720) has been shown to alleviate disease burden in immune-mediated animal models of MS, and has been approved for treatment in clinical trials in patients with MS in the United States. While the immunological effects of FTY720 are well established, there is controversy in the literature regarding the contribution of FTY720 on myelin repair. Here, we directly assessed the impact of FTY720 on myelin repair in cuprizone and lysolecithin (LPC) demyelination models that have a minimal immunological component. FTY720 failed to promote remyelination in either animal model. These studies suggest that while FTY720 may be effective at modulating the immunological attack in MS, it may benefit from an add-on therapy to enhance the myelin repair required for long-term functional restoration in MS. SN - 1095-9327 UR - https://www.unboundmedicine.com/medline/citation/21740973/Sphingosine_1_phosphate_receptor_modulator_fingolimod__FTY720__does_not_promote_remyelination_in_vivo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1044-7431(11)00136-9 DB - PRIME DP - Unbound Medicine ER -