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Activation of cannabinoid CB1 receptors in the central amygdala impairs inhibitory avoidance memory consolidation via NMDA receptors.
Neurobiol Learn Mem. 2011 Sep; 96(2):333-8.NL

Abstract

In the present study, we investigated the influence of bilateral intra-central amygdala (intra-CeA) microinjections of N-methyl-D-aspartate (NMDA) receptor agents on amnesia induced by a cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA). This study used a step-through inhibitory (passive) avoidance task to assess memory in adult male Wistar rats. The results showed that intra-CeA administration of ACPA (2 ng/rat) immediately after training decreased inhibitory avoidance (IA) memory consolidation as evidenced by a decrease in step-through latency on the test day, which was suggestive of drug-induced amnesia. Post-training intra-CeA microinjections of NMDA (0.0001, 0.001 and 0.01 μg/rat) did not affect IA memory consolidation. However co-administration of NMDA with ACPA (2 ng/rat) prevented the impairment of IA memory consolidation that was induced by ACPA. Although post-training intra-CeA administration of the NMDA receptor antagonist, D-(-)-2-amino-5-phosphonopentanoic acid (D-AP5; 0.01, 0.05 and 0.1 μg/rat) alone had no effect, its co-administration with an ineffective dose of ACPA (1 ng/rat) impaired IA memory consolidation. Post-training intra-CeA microinjection of an ineffective dose of D-AP5 (0.01 μg/rat) prevented an NMDA response to the impaired effect of ACPA. These results suggest that amnesia induced by intra-CeA administration of ACPA is at least partly mediated through an NMDA receptor mechanism in the Ce-A.

Authors+Show Affiliations

Institute for Cognitive Science Studies, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21740975

Citation

Ghiasvand, Maryam, et al. "Activation of Cannabinoid CB1 Receptors in the Central Amygdala Impairs Inhibitory Avoidance Memory Consolidation Via NMDA Receptors." Neurobiology of Learning and Memory, vol. 96, no. 2, 2011, pp. 333-8.
Ghiasvand M, Rezayof A, Zarrindast MR, et al. Activation of cannabinoid CB1 receptors in the central amygdala impairs inhibitory avoidance memory consolidation via NMDA receptors. Neurobiol Learn Mem. 2011;96(2):333-8.
Ghiasvand, M., Rezayof, A., Zarrindast, M. R., & Ahmadi, S. (2011). Activation of cannabinoid CB1 receptors in the central amygdala impairs inhibitory avoidance memory consolidation via NMDA receptors. Neurobiology of Learning and Memory, 96(2), 333-8. https://doi.org/10.1016/j.nlm.2011.06.008
Ghiasvand M, et al. Activation of Cannabinoid CB1 Receptors in the Central Amygdala Impairs Inhibitory Avoidance Memory Consolidation Via NMDA Receptors. Neurobiol Learn Mem. 2011;96(2):333-8. PubMed PMID: 21740975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activation of cannabinoid CB1 receptors in the central amygdala impairs inhibitory avoidance memory consolidation via NMDA receptors. AU - Ghiasvand,Maryam, AU - Rezayof,Ameneh, AU - Zarrindast,Mohammad Reza, AU - Ahmadi,Shamseddin, Y1 - 2011/06/29/ PY - 2010/12/18/received PY - 2011/05/31/revised PY - 2011/06/17/accepted PY - 2011/7/12/entrez PY - 2011/7/12/pubmed PY - 2011/12/28/medline SP - 333 EP - 8 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 96 IS - 2 N2 - In the present study, we investigated the influence of bilateral intra-central amygdala (intra-CeA) microinjections of N-methyl-D-aspartate (NMDA) receptor agents on amnesia induced by a cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA). This study used a step-through inhibitory (passive) avoidance task to assess memory in adult male Wistar rats. The results showed that intra-CeA administration of ACPA (2 ng/rat) immediately after training decreased inhibitory avoidance (IA) memory consolidation as evidenced by a decrease in step-through latency on the test day, which was suggestive of drug-induced amnesia. Post-training intra-CeA microinjections of NMDA (0.0001, 0.001 and 0.01 μg/rat) did not affect IA memory consolidation. However co-administration of NMDA with ACPA (2 ng/rat) prevented the impairment of IA memory consolidation that was induced by ACPA. Although post-training intra-CeA administration of the NMDA receptor antagonist, D-(-)-2-amino-5-phosphonopentanoic acid (D-AP5; 0.01, 0.05 and 0.1 μg/rat) alone had no effect, its co-administration with an ineffective dose of ACPA (1 ng/rat) impaired IA memory consolidation. Post-training intra-CeA microinjection of an ineffective dose of D-AP5 (0.01 μg/rat) prevented an NMDA response to the impaired effect of ACPA. These results suggest that amnesia induced by intra-CeA administration of ACPA is at least partly mediated through an NMDA receptor mechanism in the Ce-A. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/21740975/Activation_of_cannabinoid_CB1_receptors_in_the_central_amygdala_impairs_inhibitory_avoidance_memory_consolidation_via_NMDA_receptors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(11)00119-5 DB - PRIME DP - Unbound Medicine ER -