Tags

Type your tag names separated by a space and hit enter

Retinol-binding protein 4 is not associated with insulin resistance in pregnancy.
Metabolism. 2012 Jan; 61(1):65-9.M

Abstract

Retinol-binding protein 4 (RBP4) is an adipokine proposed to be specifically associated with insulin resistance (IR). We examined whether serum levels of RBP4 were associated with IR in pregnancy. One hundred seventy-two women with gestational diabetes mellitus (GDM) and 361 pregnant Thai women who did not have GDM but had a positive 50-g glucose challenge test result (plasma glucose level was ≥7.2 mmol/L after 1 hour) were enrolled. We measured fasting serum levels of RBP4 and assessed IR at a 100-g oral glucose tolerance test. We found a higher degree of IR in the GDM group compared with the non-GDM group, but serum RBP4 levels between the 2 groups were not different. Retinol-binding protein 4 levels were associated with serum triglyceride levels but were not associated with the degree of IR assessed by homeostasis model assessment or quantitative insulin sensitivity check index. Our results suggest that serum RBP4 levels in pregnancy are not associated with IR.

Authors+Show Affiliations

Endocrine, Hormone and Metabolism Research Unit, and Endocrinology and Metabolism Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, Patumwan, Bangkok, Thailand. wkhovid@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21741059

Citation

Khovidhunkit, Weerapan, et al. "Retinol-binding Protein 4 Is Not Associated With Insulin Resistance in Pregnancy." Metabolism: Clinical and Experimental, vol. 61, no. 1, 2012, pp. 65-9.
Khovidhunkit W, Pruksakorn P, Plengpanich W, et al. Retinol-binding protein 4 is not associated with insulin resistance in pregnancy. Metab Clin Exp. 2012;61(1):65-9.
Khovidhunkit, W., Pruksakorn, P., Plengpanich, W., & Tharavanij, T. (2012). Retinol-binding protein 4 is not associated with insulin resistance in pregnancy. Metabolism: Clinical and Experimental, 61(1), 65-9. https://doi.org/10.1016/j.metabol.2011.05.019
Khovidhunkit W, et al. Retinol-binding Protein 4 Is Not Associated With Insulin Resistance in Pregnancy. Metab Clin Exp. 2012;61(1):65-9. PubMed PMID: 21741059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinol-binding protein 4 is not associated with insulin resistance in pregnancy. AU - Khovidhunkit,Weerapan, AU - Pruksakorn,Promphan, AU - Plengpanich,Wanee, AU - Tharavanij,Thipaporn, Y1 - 2011/07/07/ PY - 2011/02/24/received PY - 2011/04/06/revised PY - 2011/05/21/accepted PY - 2011/7/12/entrez PY - 2011/7/12/pubmed PY - 2012/4/6/medline SP - 65 EP - 9 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 61 IS - 1 N2 - Retinol-binding protein 4 (RBP4) is an adipokine proposed to be specifically associated with insulin resistance (IR). We examined whether serum levels of RBP4 were associated with IR in pregnancy. One hundred seventy-two women with gestational diabetes mellitus (GDM) and 361 pregnant Thai women who did not have GDM but had a positive 50-g glucose challenge test result (plasma glucose level was ≥7.2 mmol/L after 1 hour) were enrolled. We measured fasting serum levels of RBP4 and assessed IR at a 100-g oral glucose tolerance test. We found a higher degree of IR in the GDM group compared with the non-GDM group, but serum RBP4 levels between the 2 groups were not different. Retinol-binding protein 4 levels were associated with serum triglyceride levels but were not associated with the degree of IR assessed by homeostasis model assessment or quantitative insulin sensitivity check index. Our results suggest that serum RBP4 levels in pregnancy are not associated with IR. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/21741059/Retinol_binding_protein_4_is_not_associated_with_insulin_resistance_in_pregnancy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(11)00159-4 DB - PRIME DP - Unbound Medicine ER -