Tags

Type your tag names separated by a space and hit enter

Effects of low-level sarin and cyclosarin exposure and Gulf War Illness on brain structure and function: a study at 4T.
Neurotoxicology. 2011 Dec; 32(6):814-22.N

Abstract

BACKGROUND

More than 100,000 US troops were potentially exposed to chemical warfare agents sarin (GB) and cyclosarin (GF) when an ammunition dump at Khamisiyah, Iraq was destroyed during the 1991 Persian Gulf War (GW). We previously found reduced total gray matter (GM) volume in 40 GW veterans with suspected GB/GF exposure relative to 40 matched, unexposed GW veterans on a 1.5T MR scanner. In this study, we reexamine the relationship between GB/GF exposure and volumetric measurements of gross neuroanatomical structures in a different cohort of GW veterans on a 4T MR scanner.

METHODS

Neuropsychological and magnetic resonance imaging (MRI) data from a cross sectional study on Gulf War Illness performed between 2005 and 2010 were used in this study. 4T MRI data were analyzed using automated image processing techniques that produced volumetric measurements of gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF).

RESULTS

Binary comparisons of 64 GB/GF exposed veterans and 64 'matched', unexposed veterans revealed reduced GM (p=0.03) and WM (p=0.03) volumes in the exposed veterans. Behaviorally, exposed veterans committed more errors of omission (p=0.02) and tended to have slower responses (p=0.05) than unexposed veterans on the Continuous Performance Test (CPT), a measure sustained and selective attention. Regression analyses confirmed that GB/GF exposure status predicted GM (β=-0.11, p=0.02) and WM (β=-0.14, p=0.03) volumes, and number of CPT omission errors (β=0.22, p=0.02) over and above potentially confounding demographic, clinical, and psychosocial variables. There was no dose-response relationship between estimated levels of GB/GF exposure and brain volume. However, we did find an effect of Gulf War Illness/Chronic Multisymptom Illness on both GM and WM volume in the GB/GF exposed veterans.

CONCLUSIONS

These findings confirm previous reports by our group and others of central nervous system pathology in GW veterans with suspected exposure to low levels of GB/GF two decades after the exposure.

Authors+Show Affiliations

Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA. linda.chao@ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21741405

Citation

Chao, Linda L., et al. "Effects of Low-level Sarin and Cyclosarin Exposure and Gulf War Illness On Brain Structure and Function: a Study at 4T." Neurotoxicology, vol. 32, no. 6, 2011, pp. 814-22.
Chao LL, Abadjian L, Hlavin J, et al. Effects of low-level sarin and cyclosarin exposure and Gulf War Illness on brain structure and function: a study at 4T. Neurotoxicology. 2011;32(6):814-22.
Chao, L. L., Abadjian, L., Hlavin, J., Meyerhoff, D. J., & Weiner, M. W. (2011). Effects of low-level sarin and cyclosarin exposure and Gulf War Illness on brain structure and function: a study at 4T. Neurotoxicology, 32(6), 814-22. https://doi.org/10.1016/j.neuro.2011.06.006
Chao LL, et al. Effects of Low-level Sarin and Cyclosarin Exposure and Gulf War Illness On Brain Structure and Function: a Study at 4T. Neurotoxicology. 2011;32(6):814-22. PubMed PMID: 21741405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of low-level sarin and cyclosarin exposure and Gulf War Illness on brain structure and function: a study at 4T. AU - Chao,Linda L, AU - Abadjian,Linda, AU - Hlavin,Jennifer, AU - Meyerhoff,Deiter J, AU - Weiner,Michael W, Y1 - 2011/06/29/ PY - 2011/05/04/received PY - 2011/06/17/revised PY - 2011/06/18/accepted PY - 2011/7/12/entrez PY - 2011/7/12/pubmed PY - 2012/5/4/medline SP - 814 EP - 22 JF - Neurotoxicology JO - Neurotoxicology VL - 32 IS - 6 N2 - BACKGROUND: More than 100,000 US troops were potentially exposed to chemical warfare agents sarin (GB) and cyclosarin (GF) when an ammunition dump at Khamisiyah, Iraq was destroyed during the 1991 Persian Gulf War (GW). We previously found reduced total gray matter (GM) volume in 40 GW veterans with suspected GB/GF exposure relative to 40 matched, unexposed GW veterans on a 1.5T MR scanner. In this study, we reexamine the relationship between GB/GF exposure and volumetric measurements of gross neuroanatomical structures in a different cohort of GW veterans on a 4T MR scanner. METHODS: Neuropsychological and magnetic resonance imaging (MRI) data from a cross sectional study on Gulf War Illness performed between 2005 and 2010 were used in this study. 4T MRI data were analyzed using automated image processing techniques that produced volumetric measurements of gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF). RESULTS: Binary comparisons of 64 GB/GF exposed veterans and 64 'matched', unexposed veterans revealed reduced GM (p=0.03) and WM (p=0.03) volumes in the exposed veterans. Behaviorally, exposed veterans committed more errors of omission (p=0.02) and tended to have slower responses (p=0.05) than unexposed veterans on the Continuous Performance Test (CPT), a measure sustained and selective attention. Regression analyses confirmed that GB/GF exposure status predicted GM (β=-0.11, p=0.02) and WM (β=-0.14, p=0.03) volumes, and number of CPT omission errors (β=0.22, p=0.02) over and above potentially confounding demographic, clinical, and psychosocial variables. There was no dose-response relationship between estimated levels of GB/GF exposure and brain volume. However, we did find an effect of Gulf War Illness/Chronic Multisymptom Illness on both GM and WM volume in the GB/GF exposed veterans. CONCLUSIONS: These findings confirm previous reports by our group and others of central nervous system pathology in GW veterans with suspected exposure to low levels of GB/GF two decades after the exposure. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/21741405/Effects_of_low_level_sarin_and_cyclosarin_exposure_and_Gulf_War_Illness_on_brain_structure_and_function:_a_study_at_4T_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(11)00114-8 DB - PRIME DP - Unbound Medicine ER -