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Comparison of atherosclerotic plaque by computed tomography angiography in patients with and without diabetes mellitus and with known or suspected coronary artery disease.
Am J Cardiol. 2011 Sep 15; 108(6):809-13.AJ

Abstract

The aim of this study was to compare coronary artery plaque burden, composition, distribution, and the degree of coronary artery stenosis in diabetic and nondiabetic patients with known or suspected coronary artery disease (CAD). The study group consisted of 594 patients with known or suspected CAD, including 122 diabetics, who underwent multidetector computed tomographic coronary angiography and traditional invasive coronary artery angiography. Coronary artery calcium scores were compared in different age subgroups. Noncalcified plaque, calcified plaque, and mixed plaque were analyzed by coronary segment on computed tomographic coronary angiography, as well as the degree of coronary stenosis on coronary artery angiography. Obstructive vessels were compared between the 2 groups. Total coronary artery calcium score was higher in patients with diabetes compared to those without (378.4 ± 613.0 vs 226.0 ± 408.4, p = 0.003). The percentage of patients with coronary artery calcium scores >400 among diabetics (22.1%) was higher than among nondiabetics (14.2%) (p = 0.032). Diabetics had a higher percentage of coronary segments with noncalcified plaque, calcified plaque, and mixed plaque than nondiabetics (35.3% vs 26.2%, p <0.001; 17.5% vs 11.6%, p = 0.017; and 9.8% vs 7.9%, p = 0.008). More diabetics had multivessel obstructive disease compared to nondiabetics (p <0.05). With longer duration of diabetes mellitus, the stenosed segments of coronary arteries increased accordingly. In conclusion, diabetics have more atherosclerotic plaque burden and more severe coronary atherosclerosis than nondiabetics. Most obstructive lesions were caused by mixed plaques in diabetics and nondiabetics.

Authors+Show Affiliations

Department of Radiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21741605

Citation

Gao, Yang, et al. "Comparison of Atherosclerotic Plaque By Computed Tomography Angiography in Patients With and Without Diabetes Mellitus and With Known or Suspected Coronary Artery Disease." The American Journal of Cardiology, vol. 108, no. 6, 2011, pp. 809-13.
Gao Y, Lu B, Sun ML, et al. Comparison of atherosclerotic plaque by computed tomography angiography in patients with and without diabetes mellitus and with known or suspected coronary artery disease. Am J Cardiol. 2011;108(6):809-13.
Gao, Y., Lu, B., Sun, M. L., Hou, Z. H., Yu, F. F., Cao, H. L., Chen, Y., Yang, Y. J., Jiang, S. L., & Budoff, M. J. (2011). Comparison of atherosclerotic plaque by computed tomography angiography in patients with and without diabetes mellitus and with known or suspected coronary artery disease. The American Journal of Cardiology, 108(6), 809-13. https://doi.org/10.1016/j.amjcard.2011.04.032
Gao Y, et al. Comparison of Atherosclerotic Plaque By Computed Tomography Angiography in Patients With and Without Diabetes Mellitus and With Known or Suspected Coronary Artery Disease. Am J Cardiol. 2011 Sep 15;108(6):809-13. PubMed PMID: 21741605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of atherosclerotic plaque by computed tomography angiography in patients with and without diabetes mellitus and with known or suspected coronary artery disease. AU - Gao,Yang, AU - Lu,Bin, AU - Sun,Ming L, AU - Hou,Zhi H, AU - Yu,Fang F, AU - Cao,Hui L, AU - Chen,Yang, AU - Yang,Yue J, AU - Jiang,Shi L, AU - Budoff,Matthew J, Y1 - 2011/07/07/ PY - 2011/03/01/received PY - 2011/04/27/revised PY - 2011/04/27/accepted PY - 2011/7/12/entrez PY - 2011/7/12/pubmed PY - 2011/11/1/medline SP - 809 EP - 13 JF - The American journal of cardiology JO - Am J Cardiol VL - 108 IS - 6 N2 - The aim of this study was to compare coronary artery plaque burden, composition, distribution, and the degree of coronary artery stenosis in diabetic and nondiabetic patients with known or suspected coronary artery disease (CAD). The study group consisted of 594 patients with known or suspected CAD, including 122 diabetics, who underwent multidetector computed tomographic coronary angiography and traditional invasive coronary artery angiography. Coronary artery calcium scores were compared in different age subgroups. Noncalcified plaque, calcified plaque, and mixed plaque were analyzed by coronary segment on computed tomographic coronary angiography, as well as the degree of coronary stenosis on coronary artery angiography. Obstructive vessels were compared between the 2 groups. Total coronary artery calcium score was higher in patients with diabetes compared to those without (378.4 ± 613.0 vs 226.0 ± 408.4, p = 0.003). The percentage of patients with coronary artery calcium scores >400 among diabetics (22.1%) was higher than among nondiabetics (14.2%) (p = 0.032). Diabetics had a higher percentage of coronary segments with noncalcified plaque, calcified plaque, and mixed plaque than nondiabetics (35.3% vs 26.2%, p <0.001; 17.5% vs 11.6%, p = 0.017; and 9.8% vs 7.9%, p = 0.008). More diabetics had multivessel obstructive disease compared to nondiabetics (p <0.05). With longer duration of diabetes mellitus, the stenosed segments of coronary arteries increased accordingly. In conclusion, diabetics have more atherosclerotic plaque burden and more severe coronary atherosclerosis than nondiabetics. Most obstructive lesions were caused by mixed plaques in diabetics and nondiabetics. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/21741605/Comparison_of_atherosclerotic_plaque_by_computed_tomography_angiography_in_patients_with_and_without_diabetes_mellitus_and_with_known_or_suspected_coronary_artery_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(11)01775-9 DB - PRIME DP - Unbound Medicine ER -