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Diagnostic evaluation of type 2 (classic) choroidal neovascularization: optical coherence tomography, indocyanine green angiography, and fluorescein angiography.
Am J Ophthalmol. 2011 Nov; 152(5):799-806.e1.AJ

Abstract

PURPOSE

To evaluate the diagnostic characteristics of type 2 (classic) choroidal neovascularizations secondary to age-related macular degeneration using spectral domain-optical coherence tomography (SD OCT), indocyanine green angiography (ICGA), and fluorescein angiography (FA).

DESIGN

Observational case series.

SETTING

Institutional.

STUDY POPULATION

Thirteen treatment-naïve eyes with type 2 choroidal neovascularization without an occult component.

MAIN OUTCOME MEASURES

Greatest horizontal dimension, based on the anatomic features of the neovascular complex by SD OCT (Spectralis; Heidelberg Engineering), ICGA, and FA; retinal leakage area in late-phase FA and ICGA; and the area of retinal edema in SD OCT.

OBSERVATION PROCEDURES

For direct comparison, ICGA and FA images were overlaid manually on infrared plus SD OCT images using VirtualDub and Paint.NET software. Greatest horizontal dimension was measured using Image J software (National Institutes of Health).

RESULTS

The mean greatest horizontal dimension of the neovascular complex and the retinal leakage area consistently were smaller on ICGA compared with the area of retinal edema on SD OCT. According to FA, the greatest horizontal dimension of early, well-demarcated hyperfluorescence was significantly smaller than the neovascular complex on SD OCT. In addition, the greatest horizontal dimension of the retinal leakage area in late-phase FA consistently was smaller than the area of retinal edema on SD OCT.

CONCLUSIONS

In classic choroidal neovascularization, ICGA and FA seem to underestimate the extension of the neovascular complex and the associated retinal pathologic features compared with SD OCT imaging.

Authors+Show Affiliations

Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21742302

Citation

Sulzbacher, Florian, et al. "Diagnostic Evaluation of Type 2 (classic) Choroidal Neovascularization: Optical Coherence Tomography, Indocyanine Green Angiography, and Fluorescein Angiography." American Journal of Ophthalmology, vol. 152, no. 5, 2011, pp. 799-806.e1.
Sulzbacher F, Kiss C, Munk M, et al. Diagnostic evaluation of type 2 (classic) choroidal neovascularization: optical coherence tomography, indocyanine green angiography, and fluorescein angiography. Am J Ophthalmol. 2011;152(5):799-806.e1.
Sulzbacher, F., Kiss, C., Munk, M., Deak, G., Sacu, S., & Schmidt-Erfurth, U. (2011). Diagnostic evaluation of type 2 (classic) choroidal neovascularization: optical coherence tomography, indocyanine green angiography, and fluorescein angiography. American Journal of Ophthalmology, 152(5), 799-e1. https://doi.org/10.1016/j.ajo.2011.04.011
Sulzbacher F, et al. Diagnostic Evaluation of Type 2 (classic) Choroidal Neovascularization: Optical Coherence Tomography, Indocyanine Green Angiography, and Fluorescein Angiography. Am J Ophthalmol. 2011;152(5):799-806.e1. PubMed PMID: 21742302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic evaluation of type 2 (classic) choroidal neovascularization: optical coherence tomography, indocyanine green angiography, and fluorescein angiography. AU - Sulzbacher,Florian, AU - Kiss,Christopher, AU - Munk,Marion, AU - Deak,Gabor, AU - Sacu,Stefan, AU - Schmidt-Erfurth,Ursula, Y1 - 2011/07/13/ PY - 2010/09/08/received PY - 2011/04/01/revised PY - 2011/04/01/accepted PY - 2011/7/12/entrez PY - 2011/7/12/pubmed PY - 2011/12/15/medline SP - 799 EP - 806.e1 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 152 IS - 5 N2 - PURPOSE: To evaluate the diagnostic characteristics of type 2 (classic) choroidal neovascularizations secondary to age-related macular degeneration using spectral domain-optical coherence tomography (SD OCT), indocyanine green angiography (ICGA), and fluorescein angiography (FA). DESIGN: Observational case series. SETTING: Institutional. STUDY POPULATION: Thirteen treatment-naïve eyes with type 2 choroidal neovascularization without an occult component. MAIN OUTCOME MEASURES: Greatest horizontal dimension, based on the anatomic features of the neovascular complex by SD OCT (Spectralis; Heidelberg Engineering), ICGA, and FA; retinal leakage area in late-phase FA and ICGA; and the area of retinal edema in SD OCT. OBSERVATION PROCEDURES: For direct comparison, ICGA and FA images were overlaid manually on infrared plus SD OCT images using VirtualDub and Paint.NET software. Greatest horizontal dimension was measured using Image J software (National Institutes of Health). RESULTS: The mean greatest horizontal dimension of the neovascular complex and the retinal leakage area consistently were smaller on ICGA compared with the area of retinal edema on SD OCT. According to FA, the greatest horizontal dimension of early, well-demarcated hyperfluorescence was significantly smaller than the neovascular complex on SD OCT. In addition, the greatest horizontal dimension of the retinal leakage area in late-phase FA consistently was smaller than the area of retinal edema on SD OCT. CONCLUSIONS: In classic choroidal neovascularization, ICGA and FA seem to underestimate the extension of the neovascular complex and the associated retinal pathologic features compared with SD OCT imaging. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/21742302/Diagnostic_evaluation_of_type_2__classic__choroidal_neovascularization:_optical_coherence_tomography_indocyanine_green_angiography_and_fluorescein_angiography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(11)00322-9 DB - PRIME DP - Unbound Medicine ER -